{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:39:51Z","timestamp":1784943591113,"version":"3.55.0"},"reference-count":1,"publisher":"Akademiai Kiado Zrt.","issue":"27","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Hematopoietic stem cell transplantation associated thrombotic microangiopathy is a multifactorial complication, and has variable incidence in study populations due to different diagnostic criteria. The diversity of activity parameters, like elevated lakt\u00e1t-dehidrogen\u00e1z, hematological parameters and kidney function are not specific variables after stem cell transplantation. Dysregulation of the classical and alternative pathway can play an important role in the pathomechanism of thrombotic microangiopathy, but the understanding of the role of complement activation under transplantation conditions requires further investigation. Monitoring of complement parameters, including terminal complement pathway activation complex during transplantation may help physicians to improve diagnostic strategy, to evaluate therapeutical options and to predict and follow up efficacy of complement blockade methods and supportive therapy. This review focuses on the development of diagnostic criteria and therapeutical options in thrombotic microangiopathy, and presents some preliminary findings while using different diagnostic criteria in pediatric patients. Orv Hetil. 2017; 158(27): 1043\u20131050. <\/jats:p>","DOI":"10.1556\/650.2017.30786","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T09:37:40Z","timestamp":1499074660000},"page":"1043-1050","source":"Crossref","is-referenced-by-count":1,"title":["V\u00e1ltoz\u00e1sok az \u0151ssejt-transzplant\u00e1ci\u00f3hoz t\u00e1rsult                     thromboticus microangiopathia diagnosztikus                     krit\u00e9riumrendszer\u00e9ben"],"prefix":"10.1556","volume":"158","author":[{"given":"Orsolya","family":"Horv\u00e1th","sequence":"first","affiliation":[{"name":"Doktori Iskola, Semmelweis Egyetem Budapest"},{"name":"Gyermekhematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137. 11\/4A, 1097"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Proh\u00e1szka","sequence":"additional","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, III. Belgy\u00f3gy\u00e1szati                     Klinika, Semmelweis Egyetem Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriszti\u00e1n","family":"K\u00e1llay","sequence":"additional","affiliation":[{"name":"Gyermekhematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137. 11\/4A, 1097"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Kassa","sequence":"additional","affiliation":[{"name":"Gyermekhematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137. 11\/4A, 1097"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Str\u00e9hn","sequence":"additional","affiliation":[{"name":"Gyermekhematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137. 11\/4A, 1097"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Csord\u00e1s","sequence":"additional","affiliation":[{"name":"Gyermekhematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137. 11\/4A, 1097"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Sink\u00f3","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Kriv\u00e1n","sequence":"additional","affiliation":[{"name":"Gyermekhematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         Egyes\u00edtett Szent Istv\u00e1n \u00e9s Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Budapest, Albert Fl\u00f3ri\u00e1n \u00fat 5\u20137. 11\/4A, 1097"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.39"}],"container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:12:26Z","timestamp":1550607146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":1,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1556\/650.2017.30786"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30786","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}