{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:23:31Z","timestamp":1778739811900,"version":"3.51.4"},"reference-count":1,"publisher":"Akademiai Kiado Zrt.","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: The isolated haploinsufficiency of the SHOX gene is one of the most common cause of short stature determined by monogenic mutations. The heterozygous deviation of the gene can be detected in 2\u201315% of patients with idiopathic short stature (ISS), in 50\u201390% of patients with Leri-Weill dyschondrosteosis syndrome (LWS), and in almost 100% of patients with Turner syndrome. Aim: The aim of our study was to evaluate the frequency of SHOX gene haploinsufficiency in children with ISS, LWS and in patients having Turner syndrome phenotype (TF), but normal karyotype, and to identify the dysmorphic signs characteristic for SHOX gene deficiency. Method: A total of 144 patients were included in the study. Multiplex Ligation-dependent Probe Amplification (MLPA) method was used to identify the SHOX gene haploinsufficiency. The relationships between clinical data (axiological parameters, skeletal disorders, dysmorphic signs) and genotype were analyzed by statistical methods. Results: 11 (7.6%) of the 144 patients showed SHOX gene deficiency with female dominance (8\/11, 81% female). The SHOX positive patients had a significantly higher BMI (in 5\/11 vs. 20\/133 cases, p&lt;0.02) and presented more frequent dysmorphic signs (9\/11vs 62\/133, p = 0.02). Madelung deformity of the upper limbs was also significantly more frequent among the SHOX positive patients (4\/11, i.e. 36%, vs. 14\/133, i.e. 10%, p = 0.0066). There were no statistically significant differences between the mean age, mean height and auxological measurements (sitting height\/height, arm span\/height) between the two groups of patients. Conclusions: The occurrence of SHOX gene haploinsufficiency observed in our population corresponds to the literature data. In SHOX positive patients, in addition to short stature, the dysmorphic signs have a positive predictive value for SHOX gene alterations. However, the SHOX deletion detected in a patient with idiopathic short stature without dysmorphic signs suggest that SHOX deletion analysis can be recommended in patients with ISS. Orv Hetil. 2017; 158(34): 1351\u20131356. <\/jats:p>","DOI":"10.1556\/650.2017.30829","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T04:12:17Z","timestamp":1503288737000},"page":"1351-1356","source":"Crossref","is-referenced-by-count":4,"title":["A <i>SHOX<\/i> g\u00e9ndeletio el\u0151fordul\u00e1sa                     idiop\u00e1thi\u00e1s alacsonyn\u00f6v\u00e9sben. <i>Multicentrikus                     tanulm\u00e1ny<\/i>"],"prefix":"10.1556","volume":"158","author":[{"given":"Anna","family":"D\u00e1vid","sequence":"first","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"},{"name":"Marosv\u00e1s\u00e1rhelyi Orvostudom\u00e1nyi \u00e9s Gy\u00f3gyszertudom\u00e1nyi Egyetem Marosv\u00e1s\u00e1rhely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriett","family":"Butz","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"},{"name":"Laborat\u00f3riumi Medicina Int\u00e9zet, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, Szentkir\u00e1lyi utca 46., 1088"},{"name":"Molekul\u00e1ris Medicina Kutat\u00f3csoport, Magyar Tudom\u00e1nyos Akad\u00e9mia\u2013Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita","family":"Hal\u00e1sz","sequence":"additional","affiliation":[{"name":"I. Gyermekgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"II. Gyermekgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Nyir\u0151","sequence":"additional","affiliation":[{"name":"Molekul\u00e1ris Medicina Kutat\u00f3csoport, Magyar Tudom\u00e1nyos Akad\u00e9mia\u2013Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gota","family":"Muzsnai","sequence":"additional","affiliation":[{"name":"Szent J\u00e1nos K\u00f3rh\u00e1z \u00e9s \u00c9szak-budai Egyes\u00edtett K\u00f3rh\u00e1zak Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violetta","family":"Cs\u00e1kv\u00e1ry","sequence":"additional","affiliation":[{"name":"Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Luczay","sequence":"additional","affiliation":[{"name":"I. Gyermekgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Sallai","sequence":"additional","affiliation":[{"name":"II. Gyermekgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"Hossz\u00fa","sequence":"additional","affiliation":[{"name":"II. 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