{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:04:41Z","timestamp":1792184681450,"version":"4.4.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: Structure, importance and incidence and clinical role of macro-TSH not clarified in thyroid diseases. Aim: This study was undertaken to determine the incidence and biological role of macro-TSH in patients with Hashimoto\u2019s thyroiditis. Method: Blood samples taken from patients with Hashimoto\u2019s thyroiditis were screened for the presence of macro-TSH with the polyethylene glycol method and confirmed with protein G agarose absorption test and gel filtration chromatography. Stimulatory capacity of macro-TSH was measured by CHO cells bio-assay. Patients were treated with L-thyroxine (mean 66.5 \u00b5g\/day) and half of them with selenium (mean 60 \u00b5g\/day), respectively. Results: 880 patients (728 female, aged 44.8 yr) with Hashimoto\u2019s thyroiditis was involved in the study. Macro-TSH was found in the serum of 41 patients (4.6%), the mean TSH 185.4 \u00b1 35 IU\/l was before PEG precipitations and after 5.55 \u00b1 1.8 IU\/l. Titre of anti-TPO proved to be 445 \u00b1 51 IU\/l and gradulally decreased to 212 \u00b1 51 IU\/l after one year therapy. Both the precipitation, protein G absorption and gel chromatography supported the presence of anti-TSH antibody in the macro-TSH complex. Stimulatory capacity of macro-TSH on CHO bio-assay was not proved. The macro-TSH was detected in the selenium not treated group for 18 \u00b1 3.2 months, selenium-treated for 12 \u00b1 1.9 months. Conclusion: It is concluded that anti-human TSH autoantibodies are a major components of macro-TSH and may cause diagnostic and therapeutical difficulties. The PEG precipitation is a suitable screening method for detection of macro-TSH. Selenium is able to decrease of anti-TPO antibodies and macro-TSH, respectively. When the TSH level is greater than 40.0 IU\/l, without the signs of hypothyroidism, the presence of macro-TSH is to be considered. Orv Hetil. 2017; 158(34): 1346\u20131350. <\/jats:p>","DOI":"10.1556\/650.2017.30831","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T04:12:17Z","timestamp":1503288737000},"page":"1346-1350","source":"Crossref","is-referenced-by-count":4,"title":["A makro-TSH diagnosztikus \u00e9s ter\u00e1pi\u00e1s jelent\u0151s\u00e9ge                     Hashimoto-thyreoiditises betegekben"],"prefix":"10.1556","volume":"158","author":[{"given":"Csaba","family":"Bal\u00e1zs","sequence":"first","affiliation":[{"name":"Budai Endokrin K\u00f6zpont Budapest, L\u00f6v\u0151h\u00e1z u 1\u20135., 1024"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1roly","family":"\u2020R\u00e1cz","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T14:45:40Z","timestamp":1550587540000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":0,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1556\/650.2017.30831"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30831","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}