{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T07:17:18Z","timestamp":1675235838081},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: The 8th edition of the Tumor-Node-Metastasis (TNM) based staging of breast cancer introduces a prognostic stage influenced by biomarkers along the traditional T, N and M categories. Aim: To retrospectively assess stage influencing prognostic variables; and the anatomic and prognostic stages on the basis of the overall survival (OS) of a cohort of deceased patients once diagnosed with breast cancer. Method: We included patients with known causes of death certified at the B\u00e1cs-Kiskun County Teaching Hospital and having a history of breast cancer diagnosed on a resection specimen at the same institution. Prognostic factors were obtained from the histopathological reports. Statistics included one-way ANOVA, Dunn\u2019s post hoc test and Kaplan-Meier curve analyses. Results: The 303 patients grouped as breast cancer related death (n = 168) or unrelated (n = 135) showed significant differences in most stage defining prognostic factors and the anatomic and prognostic stages. Significant differences in 5-year OS were observed between pT and pN categories, histological grades and estrogen receptor statuses. Except for stages I and II, significant differences were found between both different anatomic and prognostic stages (p&lt;0.001). Stage IV is by definition uniform, but we identified survival differences between biomarker based subgroups: triple negative carcinomas had worse OS than estrogen receptor positive and HER2 negative carcinomas. Conclusions: Our analysis based on real survival data suggests that the prognostic stages separate patients according to OS similarly to the anatomic stages. The results validate the prognostic stages, but also suggest that separating stage IV disease according to biomarkers makes sense. Orv Hetil. 2017; 158(35): 1373\u20131381. <\/jats:p>","DOI":"10.1556\/650.2017.30849","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T04:52:44Z","timestamp":1503982364000},"page":"1373-1381","source":"Crossref","is-referenced-by-count":6,"title":["Eml\u0151r\u00e1kok TNM-8 szerinti anat\u00f3miai \u00e9s prognosztikai                     st\u00e1diumainak retrospekt\u00edv vizsg\u00e1lata elhunyt, valaha eml\u0151r\u00e1kos betegek adatai                     alapj\u00e1n"],"prefix":"10.1556","volume":"158","author":[{"given":"Tam\u00e1s","family":"Zombori","sequence":"first","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai Int\u00e9zet,                         Szegedi Tudom\u00e1nyegyetem Szeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Leh\u00f3czky","sequence":"additional","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai Int\u00e9zet,                         Szegedi Tudom\u00e1nyegyetem Szeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1lint","family":"Cserni","sequence":"additional","affiliation":[{"name":"Term\u00e9szettudom\u00e1nyi \u00e9s Informatikai Kar, Informatikai                     Int\u00e9zet, Szoftverfejleszt\u00e9s Tansz\u00e9k, Szegedi Tudom\u00e1nyegyetem Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"Ny\u00e1ri","sequence":"additional","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvosi Fizikai \u00e9s Orvosi                     Informatikai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Cserni","sequence":"additional","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Patol\u00f3giai Int\u00e9zet,                         Szegedi Tudom\u00e1nyegyetem Szeged, \u00c1llom\u00e1s u. 1., 6725"},{"name":"B\u00e1cs-Kiskun Megyei Oktat\u00f3 K\u00f3rh\u00e1z Kecskem\u00e9t"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T14:42:15Z","timestamp":1550587335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":0,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1556\/650.2017.30849"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30849","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9]]}}}