{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:56:28Z","timestamp":1783137388581,"version":"3.54.6"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"41","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: Extranodal natural killer\/T (NK\/T) cell lymphoma, nasal type (ENKTL) represents a rare subtype of T-cell lymphomas with aggressive clinical behavior according to WHO 2016 classification. Aim: ENKTL has distinctive geographic distribution with higher incidence in Asia and Latin America (10% of all non-Hodgkin lymphoma cases), than in Europe and North America (&lt;1%). ENKTL tipically origins from nasopharynx and upper aerodigestive tract. Anthracycline-based chemotherapy regimens are largely ineffective in the treatment of ENKTL. Method: Our aims were to evaluate the incidence and treatment strategies of ENKTL patients in Hungarian Haematological Centres between 2003 and 2015. Altogether 20 patients with ENKTL were treated in the 4 haematological hospitals (male:female ratio 12:8, with median 49.5 years of age). Results: Ten patients had localized (stage I\u2013II) disease at the time of the diagnosis. Seventeen patients were treated with chemotherapy (11\/CHOP, CHOP-like, 2\/HyperCVAD, 1\/ProMACECytaBom, 1\/SMILE, 2\/others), which was completed with involved-field radiation therapy (IFRT) (40\u201346 Gy) in 6 cases were used. After first-line therapy 9 patients achieved complete remission (CR), 3 patients had partial remission (PR), 3 patients had progressive disease (PD), and 2 patients had stable disease (SD). Median follow-up was 32 (3\u2013113) months. Five patients received second-line therapy for progressive or recurrent disease [2\/DHAP, 1\/VIM, 1\/HyperCVAD, 1\/ProMACECytaBom]. None of the patients achieved CR after second-line therapy. Two patients have undergone autologous hematopoietic stem cell transplantation (HSCT) after the first CR. Conclusion: ENKTL treatment is more effective with nonanthracycline-containing regimens. L-asparaginase containing chemotherapy and concurrent or sequential chemo-radiotherapy improves survival and CR rates. Orv Hetil. 2017; 158(41): 1635\u20131641. <\/jats:p>","DOI":"10.1556\/650.2017.30871","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T05:13:26Z","timestamp":1507871606000},"page":"1635-1641","source":"Crossref","is-referenced-by-count":4,"title":["Nasalis t\u00edpus\u00fa extranodalis natural killer T-sejtes                     lymphoma hazai el\u0151fordul\u00e1sa \u00e9s kezel\u00e9s\u00e9vel szerzett                     tapasztalatok"],"prefix":"10.1556","volume":"158","author":[{"given":"Annam\u00e1ria","family":"Bakos","sequence":"first","affiliation":[{"name":"Nukle\u00e1ris Medicina Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 6., 6721"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1rp\u00e1d","family":"Szomor","sequence":"additional","affiliation":[{"name":"Klinikai K\u00f6zpont, I. Belgy\u00f3gy\u00e1szati Klinika,                         P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Schneider","sequence":"additional","affiliation":[{"name":"Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Milt\u00e9nyi","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Hematol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Marton","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika \u00e9s Kardiol\u00f3giai K\u00f6zpont,                     Hematol\u00f3giai Oszt\u00e1ly, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zita","family":"Borb\u00e9nyi","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika \u00e9s Kardiol\u00f3giai K\u00f6zpont,                     Hematol\u00f3giai Oszt\u00e1ly, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Pammer","sequence":"additional","affiliation":[{"name":"Klinikai K\u00f6zpont, I. Belgy\u00f3gy\u00e1szati Klinika,                         P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kren\u00e1cs","sequence":"additional","affiliation":[{"name":"Daganatpatol\u00f3giai \u00e9s Molekul\u00e1ris Diagnosztikai                     Laborat\u00f3rium, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Bagdi","sequence":"additional","affiliation":[{"name":"Daganatpatol\u00f3giai \u00e9s Molekul\u00e1ris Diagnosztikai                     Laborat\u00f3rium, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Piukovics","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika \u00e9s Kardiol\u00f3giai K\u00f6zpont,                     Hematol\u00f3giai Oszt\u00e1ly, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2017.30871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:52:48Z","timestamp":1550605968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2017.30871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":0,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1556\/650.2017.30871"],"URL":"https:\/\/doi.org\/10.1556\/650.2017.30871","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}