{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:15:06Z","timestamp":1648739706406},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Moderate thrombocytosis can accompany several diseases (bleeding, inflammation, iron deficiency, or autoimmune diseases), but hematologic examination is strongly recommended in a patient with persistent platelet count above 450 G\/L unless reactive origin can be confirmed. The 47-year-old woman\u2019s medical history included hypertonia, asthma bronchiale, and endometriosis. In March 2015, she underwent laboratory examination due to weight loss and lack of appetite. Her results showed elevated thrombocyte count (617 G\/L), but no iron deficiency. She presented in our clinic on 07. 04. 2015 with acute pain below her left hypochondrial region, but simple imaging examinations showed no difference to explain it. Abdominal CT revealed a 4.5 cm thrombus which protruded into the left renal artery, blocking it. We started APTI- (activated partial thromboplastin time) monitored continuous intravenous treatment with unfractionated heparin. The JAK2V617F mutation analysis came back positive. Subsequent bone marrow examination revealed prefibrotic\/early stage myelofibrosis, prompting treatment with hydroxyurea. The applied treatments led to the disappearance of the patient\u2019s symptoms accompanied by the gradual normalisation of the thrombocyte count. Moderate thrombocytosis is often secondary, but if it persists and is accompanied by mainly thromboembolic events, the risk of diseases of the haematopoietic system, primarily Philadelphia chromosome negative chronic myeloproliferative disease should also be considered. Clinically, essential thrombocythaemia and the prefibrotic\/early stage of myelofibrosis can be very similar. Differential diagnosis is only possible through the histological examination of the bone marrow, which becomes indispensible due to the difference in prognosis and treatment options. Orv Hetil. 2018; 159(15): 603\u2013609. <\/jats:p>","DOI":"10.1556\/650.2018.30995","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T06:33:45Z","timestamp":1523342025000},"page":"603-609","source":"Crossref","is-referenced-by-count":0,"title":["A korai\/praefibroticus primer myelofibrosis                     kivizsg\u00e1l\u00e1sa \u00e9s kezel\u00e9se egy eset kapcs\u00e1n"],"prefix":"10.1556","volume":"159","author":[{"given":"Ferenc","family":"Magyari","sequence":"first","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Belgy\u00f3gy\u00e1szati Int\u00e9zet,                     Hematol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Bedekovics","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"D\u00e9csy","sequence":"additional","affiliation":[{"name":"Affidea Diagnosztikai Kft. Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Ilonczai","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Oszt\u00e1ly, J\u00f3sa Andr\u00e1s Oktat\u00f3k\u00f3rh\u00e1z Ny\u00edregyh\u00e1za"},{"name":"A szerz\u0151 kor\u00e1bbi munkahelye: Belgy\u00f3gy\u00e1szati Int\u00e9zet,                     Thrombosis \u00e9s Haemostasis K\u00f6zpont, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rp\u00e1d","family":"Ill\u00e9s","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Belgy\u00f3gy\u00e1szati Int\u00e9zet,                     Hematol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Simon","sequence":"additional","affiliation":[{"name":"II. Belgy\u00f3gy\u00e1szati Klinika, Belgy\u00f3gy\u00e1szati Int\u00e9zet,                     Hematol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2018.30995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:24:26Z","timestamp":1550607866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2018.30995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1556\/650.2018.30995"],"URL":"https:\/\/doi.org\/10.1556\/650.2018.30995","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}