{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T15:29:22Z","timestamp":1698766162569},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Dilated cardiomyopathy is the main cause of heart transplantation. The etiology is unknown in almost half of the cases. Many cardiac specific antibodies have been identified till now which can cause decreased cardiac function, ventricular tachycardia or sudden heart death. The prognosis of DCM is poor despite the development of medical treatment. Immunoadsorption is hopeful since, with the removal of antibodies, cardiac function and NYHA class can improve and LVAD\/heart transplantation-free survival can be prolonged. At the University of Debrecen, Faculty of Medicine, Department of Internal Medicine, Division of Angiology, Intensive Care and Therapeutic Apheresis Unit we performed the first immunoadsorption. Our patient was a 43-year-old man with idiopathic dilated cardiomyopathy, NYHA class IV, a heart transplantation candidate, whose cardiac specific antibody, type IgG was indentified by Western blot. Before the treatment he had ejection fraction of 18%. Discussing with his cardiologists we decided for immunoadsorption therapy. We performed 5 cycles on consecutive days in Intensive Care Unit. After 1 month we detected improvement in exercise capacity. We detected improvement in isovolemic contraction (from 465 mmHg\/s to 575 mmHg\/s), increased stroke volume (from 49 ml to 66 ml). After 3 months we repeated SPECT investigation which showed improvement in ejection fraction, from 18% to 32%. Orv Hetil. 2018; 159(13): 532\u2013536. <\/jats:p>","DOI":"10.1556\/650.2018.31023","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T09:47:38Z","timestamp":1521971258000},"page":"526-530","source":"Crossref","is-referenced-by-count":1,"title":["Dilatat\u00edv cardiomyopathia immunadszorpci\u00f3s kezel\u00e9se.                         <i>Az els\u0151 magyarorsz\u00e1gi eset kapcs\u00e1n<\/i>"],"prefix":"10.1556","volume":"159","author":[{"given":"P\u00e1l","family":"Solt\u00e9sz","sequence":"first","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Belgy\u00f3gy\u00e1szati Angiol\u00f3giai Nem                     \u00d6n\u00e1ll\u00f3 Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, M\u00f3ricz Zs. krt. 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda","family":"Vass","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Belgy\u00f3gy\u00e1szati Angiol\u00f3giai Nem                     \u00d6n\u00e1ll\u00f3 Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, M\u00f3ricz Zs. krt. 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Di\u00f3szegi","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Belgy\u00f3gy\u00e1szati Angiol\u00f3giai Nem                     \u00d6n\u00e1ll\u00f3 Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, M\u00f3ricz Zs. krt. 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivetta","family":"M\u00e1nyin\u00e9 Siket","sequence":"additional","affiliation":[{"name":"Kardiol\u00f3giai Int\u00e9zet, Klinikai Fiziol\u00f3gia Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Garai","sequence":"additional","affiliation":[{"name":"Orvosi K\u00e9palkot\u00f3 Int\u00e9zet, Nukle\u00e1ris Medicina Nem \u00d6n\u00e1ll\u00f3                     Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Kun","sequence":"additional","affiliation":[{"name":"Kardiol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"Bene","sequence":"additional","affiliation":[{"name":"Kardiol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Kert\u00e9sz","sequence":"additional","affiliation":[{"name":"Kardiol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"\u00c9des","sequence":"additional","affiliation":[{"name":"Kardiol\u00f3giai Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2018.31023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T20:01:06Z","timestamp":1550606466000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2018.31023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":0,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1556\/650.2018.31023"],"URL":"https:\/\/doi.org\/10.1556\/650.2018.31023","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}