{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T14:08:28Z","timestamp":1649081308486},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits is characterized by granular deposits of monoclonal IgG; histologically it has typically a membranoproliferative or endocapillary pattern, and seen electronmicroscopically there are dense deposits without substructure. Here, we present the case of a 62-year-old Caucasian woman who was admitted with rapidly progressive kidney failure. The patient\u2019s status, the laboratory and imaging examinations did not support prerenal, postrenal and \u2013 among the intrinsic causes \u2013 vascular and tubulointerstitial origin. The proteinuria and dysmorphic microhematuria suggested rapidly progressive glomerulonephritis. Tests for anti-neutrophil cytoplasmic antibodies, anti-glomerular basement membrane, antinuclear antibodies and cryoglobulins were negative, the C3 and C4 levels were normal. The biopsy evaluation diagnosed proliferative glomerulonephritis with monoclonal IgG deposits because of mesangial granular deposits of IgG3-kappa, C3, and C1q, and ultrastructurally electron-dense deposits (incidence in our adult native kidney biopsy series: 0.18%). 31 glomeruli were assessed histologically. 29 glomeruli displayed mild mesangial hypercellularity, 2 glomeruli were globally sclerotic. Crescents were not observed. Mild arteriolar hyalinosis, interstitial fibrosis and tubular atrophy accompanied the glomerular alterations. In the postbiopsy evaluation, paraprotein or multiple myeloma was not detected. Despite the mild histological findings, the kidney failure progressed, and hemodialysis had to be started two weeks after the biopsy. Steroids, cyclophosphamide and rituximab did not affect her kidney function, and she remained on hemodialysis during the follow-up of 39 months. This report presents for the first time proliferative glomerulonephritis with monoclonal IgG deposits as the possible cause of rapidly progressive nephritic syndrome in the absence of pronounced glomerular proliferative, sclerotic or tubulointerstitial lesions. Orv Hetil. 2018; 159(38): 1567\u20131572. <\/jats:p>","DOI":"10.1556\/650.2018.31072","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T11:18:48Z","timestamp":1538738328000},"page":"1567-1572","source":"Crossref","is-referenced-by-count":0,"title":["Enyhe sz\u00f6vettani elt\u00e9r\u00e9sek ellen\u00e9re gyors progresszi\u00f3j\u00fa                     proliferativ glomerulonephritis monoklon\u00e1lis                     immunglobulin-G-depozitumokkal"],"prefix":"10.1556","volume":"159","author":[{"given":"D\u00f3ra","family":"Bajcsi","sequence":"first","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Nephrologia-Hypertonia                     Centrum, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar  Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kypros","family":"Constantinou","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Nephrologia-Hypertonia                     Centrum, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar  Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Kren\u00e1cs","sequence":"additional","affiliation":[{"name":"Daganatpatol\u00f3giai \u00e9s Molekul\u00e1ris Diagnosztikai                     Laborat\u00f3rium, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Barab\u00e1s","sequence":"additional","affiliation":[{"name":"P\u00e1ndy K\u00e1lm\u00e1n Tagk\u00f3rh\u00e1z, B\u00e9k\u00e9s Megyei K\u00f6zponti K\u00f3rh\u00e1z Gyula"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"P\u00e1ndy K\u00e1lm\u00e1n Tagk\u00f3rh\u00e1z, B\u00e9k\u00e9s Megyei K\u00f6zponti K\u00f3rh\u00e1z Gyula"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szabolcs","family":"Nyiraty","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Nephrologia-Hypertonia                     Centrum, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar  Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"\u00c1brah\u00e1m","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Nephrologia-Hypertonia                     Centrum, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar  Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Iv\u00e1nyi","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2018.31072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:45:45Z","timestamp":1550605545000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2018.31072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":0,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1556\/650.2018.31072"],"URL":"https:\/\/doi.org\/10.1556\/650.2018.31072","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}