{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T06:28:36Z","timestamp":1717050516755},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: According to the present knowledge, the effect of non-steroidal anti-inflammatory drugs (NSAIDs) depends on the inhibitory ratio of cyclooxigenase (COX)-1 to COX-2 in the plasma membranes. In addition to cardiovascular and gastrointestinal side effects, there are adverse symptoms which can be divided into cross-intolerance (non-immune mediated) and single or multiple hypersensitive (immune mediated) reactions. Due to clinical phenotypes and to in vivo aspirin reactivity, adverse effects could be further classified. Aim: The aim of these studies was a comparison of hit ratios obtained by a humoral serum test measuring specific immunglobulin E (IgE) against a rapid cellular test measuring interleukin (IL)-6 release from sensitized mononuclear cells due to various suspect NSAID after symptoms within one year. Retrospective case studies were performed in in- and out-patients of our teaching hospital in Budapest, between 2003 and 2013. Method: Specific anti-NSAID IgE levels were determined by ELISA in 55 cases. The other matching group of patients consisted of 51 patients and 9 tolerant persons. Their separated cells\u2019 supernatants were checked for IL-6 release incubated for 20 minutes by NSAID dilutions including intraassay controls by two-step ELISA assay. Both groups have been stratified according to \u201cnew\u201d clinical classification. Results: Results have disclosed no significant differences among the distribution of clinical symptoms between the two groups. In both groups, 9 non-steroidal anti-inflammatory drugs were tested representing all frequently used compounds with COX-1 inhibitory potential. The overall positivity rate was nearly double (65.4% against 36.9%) within the group using IL-6 release assay against that with specific IgE as the diagnostic tool. In certain cases, non-drug components of commercial preparations prompted IL-6 release as well which was paralleled by in vivo test results. Positive in vitro tests were obtained in both groups with clinically cross-intolerant as well as single or multiple sensitized cases. Conclusion: The rates of single or multiple sensitized cases exceeded in both groups that of cross-intolerant patients. In some phenotypes belonging to the latter categories, IgE type antibodies against acetylsalicylic acid could be detected as well. IL-6 release assay was the more sensitive test. In addition to pure drugs, other ingredients of medicines could also be responsible for adverse events. Orv Hetil. 2018; 159(38): 1556\u20131566. <\/jats:p>","DOI":"10.1556\/650.2018.31170","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T11:18:48Z","timestamp":1538738328000},"page":"1556-1566","source":"Crossref","is-referenced-by-count":1,"title":["Nemszteroid gyullad\u00e1scs\u00f6kkent\u0151k okozta adverz reakci\u00f3k                     differenci\u00e1ldiagnosztik\u00e1ja. <i>In vitro \u00e9s in vivo                     m\u00f3dszerek<\/i>"],"prefix":"10.1556","volume":"159","author":[{"given":"J\u00f3zsef M\u00e1ty\u00e1s","family":"Bal\u00f3-Banga","sequence":"first","affiliation":[{"name":"Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont Budapest, Podmaniczky u. 109\u2013111., 1062"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont Budapest, Podmaniczky u. 109\u2013111., 1062"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2018.31170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:45:43Z","timestamp":1550605543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2018.31170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":0,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1556\/650.2018.31170"],"URL":"https:\/\/doi.org\/10.1556\/650.2018.31170","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}