{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:24:16Z","timestamp":1783693456572,"version":"3.55.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"39","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> To summarize ophthalmological signs of monoclonal gammopathy of undetermined significance (MGUS) and to present a case report. Summary of the literature data and presentation of the history of a 46-year-old female patient. In MGUS, pathological, but non-malignant plasma cells produce abnormal monoclonal immunoglobulin. Its prevalence is 0.15%, but it increases with age. As yearly 1\u20132% of MGUS patients develop multiple myeloma, frequent hematological follow-up is necessary. Corneal opacifications in MGUS have been described in a few dozens of patients in the literature. These may be nummular or crystal-like, or even present with white or grey line-forming depositions in the stroma. They may be centrally or peripherally localized. In our patient, bilateral, branching, geographical corneal opacifications were detected predescemetally, that were progressing and reaching the optical centre during follow-up. With 0.15 best corrected visual acuity, penetrating keratoplasty was performed (postoperative best spectacle-corrected visual acuity 0.6). Masson trichrom staining of the explanted cornea verified protein deposition, immunhistochemistry identified kappa light chain immunglobulin deposition in the posterior stroma, surrounded with inflammatory cells. Serum electrophoresis and bone marrow biopsy of our patient proved MGUS, therefore, hematological follow-up is going on. In the case of progressive, atypical corneal opacification, the hematological diagnosis of monoclonal gammopathy must be excluded \u2013 monoclonal gammopathy of ocular significance \u2013, as delay in proper diagnosis and treatment of the systemic disease may have devastating consequences. Orv Hetil. 2018; 159(39): 1575\u20131583. <\/jats:p>","DOI":"10.1556\/650.2018.31196","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T07:16:08Z","timestamp":1538723768000},"page":"1575-1583","source":"Crossref","is-referenced-by-count":4,"title":["Szaruh\u00e1rtya-lerak\u00f3d\u00e1sok bizonytalan jelent\u0151s\u00e9g\u0171                     monoklon\u00e1lis gammopathi\u00e1ban. <i>Irodalmi \u00e1ttekint\u00e9s \u00e9s                         esetbemutat\u00e1s<\/i>"],"prefix":"10.1556","volume":"159","author":[{"given":"Orsolya","family":"N\u00e9meth","sequence":"first","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"},{"name":"Szem\u00e9szeti Oszt\u00e1ly, Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Szombathely"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta","family":"Tapaszt\u00f3","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Tar","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikt\u00f3ria","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n Zsolt","family":"Nagy","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"II. Patol\u00f3giai Int\u00e9zet, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryan","family":"Hamed","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai Oszt\u00e1ly, Petz Alad\u00e1r Megyei Oktat\u00f3 K\u00f3rh\u00e1z Gy\u0151r"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Mikala","sequence":"additional","affiliation":[{"name":"Hematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly,                         D\u00e9l-pesti Centrum K\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"},{"name":"Klinik f\u00fcr Augenheilkunde,                         Universit\u00e4tsklinikum des Saarlandes Homburg\/Saar, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2018.31196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T14:46:31Z","timestamp":1550587591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2018.31196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":0,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1556\/650.2018.31196"],"URL":"https:\/\/doi.org\/10.1556\/650.2018.31196","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}