{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T16:03:40Z","timestamp":1698681820663},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: The effectiveness of the manegement of stable coronary artery disease among outpatients is not well known. Aim: The aim of the study was to evaluate the effect of daily once trimetazidine prolong 80 mg on the angina number and severity (Canadian Cardiovascular Society class). Method: This multicenter, prospective, observational, 3-month clinical study included 2160 patients, but only 1701 patients completed the study. The patients\u2019 mean age was 68 years (17% under 60 years). The start of angina was 7.8 \u00b1 6.7 years. Hypertension (93.4%) and hypercholesterolemia (81%) were very common. Results: The patients were well treated with beta-blocking agents (88%), calcium antagonists (49%), angiotensin-converting enzym inhibitors (90%) and statin (77%) but only 5% received ivabradine and 50.5% was treated with trimetazidine MR. The patients attended 3 visits (inclusion, 1 month, 3 month). During the 3-month period, the weekly angina number of all patients treated with trimetazidine prolong 80 mg decreased from 2.55 to 0.41 (p&lt;0.0001). A favorable effect was observed in CCS grading: CCS I. from 40.37% to 66.81%, CCS II. from 49.89% to 30.59%, CCS III. from 9.17% to 2% and CCS IV. from 0.56% to 0%. The mean office measured blood pressure decreased from 137\/83 mmHg to 130\/80 mmHg and the heart rate from 74 bpm to 71 bpm. Conclusions: In the real-life, in the stable coronary artery disease the angina remains despite the medical treatment. Once a day administered trimetazidine prolong 80 mg significantly reduced the weekly number of angina and the severity, too. These beneficial effects mediated not only by antiischemic effect but also by increased medication adherence. Orv Hetil. 2018; 159(38): 1549\u20131555. <\/jats:p>","DOI":"10.1556\/650.2018.31251","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T11:18:48Z","timestamp":1538738328000},"page":"1549-1555","source":"Crossref","is-referenced-by-count":3,"title":["Stabil coronariabetegs\u00e9g kezel\u00e9s\u00e9re alkalmazott                     trimetazidin prolong hat\u00e1soss\u00e1g\u00e1nak vizsg\u00e1lata. <i>Multicentrikus,                         prospekt\u00edv, obszerv\u00e1ci\u00f3s, ny\u00edlt klinikai vizsg\u00e1lat,                         ONECAPS-vizsg\u00e1lat<\/i>"],"prefix":"10.1556","volume":"159","author":[{"given":"J\u00e1nos","family":"Tomcs\u00e1nyi","sequence":"first","affiliation":[{"name":"Kardiol\u00f3gia, Beteg\u00e1pol\u00f3 Irgalmasrend Budai Irgalmasrendi K\u00f3rh\u00e1za Budapest, \u00c1rp\u00e1d fejedelem \u00fatja 7., 1023"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Szak\u00e1cs","sequence":"additional","affiliation":[{"name":"WEB2 Research Kft. Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2018.31251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T19:45:44Z","timestamp":1550605544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2018.31251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":0,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1556\/650.2018.31251"],"URL":"https:\/\/doi.org\/10.1556\/650.2018.31251","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]}}}