{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:59:45Z","timestamp":1758981585745},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Facial angiofibroma is the characteristic symptom and also a major diagnostic criterion for Bourneville\u2013Pringle disease. The centrofacially localized hamartomatous tumours start to appear in early childhood, and progress over time. Facial angiofibromas represent a significant cosmetological problem for the patients and a therapeutic challenge for the physician. Beside the traditional invasive treating methods, topical sirolimus is a new, promising and well-tolerated treatment modality. Several studies and case reports have been published on this new therapeutic approach, but recommendation for the optimal sirolimus concentration still does not exist. We report here two cases when children were successfully treated with topical sirolimus. Orv Hetil. 2019; 160(13): 516\u2013520. <\/jats:p>","DOI":"10.1556\/650.2019.31244","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T06:54:07Z","timestamp":1553496847000},"page":"516-520","source":"Crossref","is-referenced-by-count":1,"title":["Lok\u00e1lis szirolimuszter\u00e1pia sikeres alkalmaz\u00e1sa facialis                     angiofibrom\u00e1k kezel\u00e9s\u00e9re Bourneville\u2013Pringle-k\u00f3rban szenved\u0151                     gyermekeken"],"prefix":"10.1556","volume":"160","author":[{"given":"Krisztina","family":"Botty\u00e1n","sequence":"first","affiliation":[{"name":"Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, B\u0151rgy\u00f3gy\u00e1szati \u00e9s                     Allergol\u00f3giai Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 6., 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, B\u0151rgy\u00f3gy\u00e1szati \u00e9s                     Allergol\u00f3giai Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 6., 6720"},{"name":"Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, Dermatol\u00f3giai                     Kutat\u00f3csoport, MTA-Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsanett Ren\u00e1ta","family":"Csoma","sequence":"additional","affiliation":[{"name":"Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, B\u0151rgy\u00f3gy\u00e1szati \u00e9s                     Allergol\u00f3giai Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 6., 6720"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T06:46:56Z","timestamp":1554014816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":0,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1556\/650.2019.31244"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31244","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}