{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T20:33:50Z","timestamp":1774730030728,"version":"3.50.1"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Since 2017, the nomenclature of Fusarium, Acremonium and Sarocladium species have changed, as these morphologically homogeneous, but phylogenetically heterogeneous species and species complexes may be differentiated using MALDI\u2013TOF MS examination, analyzing nucleotic sequences. This resulted in taxonomical changes. We summarize the clinical course, diagnostic and therapeutic options of keratitis caused by Fusarium and Sarocladium. The challenge of Fusarium and Sarocladium keratitis management for an ophthalmologist lies in delayed diagnosis and therapy, fulminant progression and penetration of the Descemet\u2019s membrane, restricted availability, poor penetration of antifungal agents and therapy resistance. The diagnosis is based on the clinical history of corneal trauma or contact lens wear, PCR and MALDI\u2013TOF MS, confocal microscopic examination, microbiological culture and light-microscopic analysis of corneal scrapings. As primary conservative treatment, 5% natamycin eye drops have to be used and with results of an antimycogram, topical 1% voriconazole or 0.15\u20130.25% amphotericin B, in some cases 0.02% polyhexamethylene-biguanide (PHMB) may be applied. Fusarium keratitis may benefit from additional 2 \u00d7 200 mg oral voriconazole treatment, daily. In therapy resistant cases, early, large diameter penetrating keratoplasty (PKP) has to be performed, with complete removal of the infected area. With late diagnosis, delayed specific treatment and surgery, mycotic hyphae may penetrate the Descemet\u2019s membrane, leading to the loss of vision and enucleation in about every fourth patient. In our paper, we also present the heterogeneous clinical history of five Fusarium and Sarocladium keratitis cases. Orv Hetil. 2019; 160(1): 2\u201311. <\/jats:p>","DOI":"10.1556\/650.2019.31259","type":"journal-article","created":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T09:48:46Z","timestamp":1546422526000},"page":"2-11","source":"Crossref","is-referenced-by-count":8,"title":["<i>Fusarium<\/i> \u00e9s                         <i>Sarocladium<\/i> okozta fert\u0151z\u00e9sek szem\u00e9szeti vonatkoz\u00e1sai \u00e9s                     azok kezel\u00e9se"],"prefix":"10.1556","volume":"160","author":[{"given":"Cec\u00edlia","family":"Czak\u00f3","sequence":"first","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"S\u00e1ndor","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Popper-Sachetti","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajnalka","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ill\u00e9s","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Imre","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Patol\u00f3giai Int\u00e9zet, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Birinyi","sequence":"additional","affiliation":[{"name":"Miksz\u00e1th Gy\u00f3gyszert\u00e1r Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n Zsolt","family":"Nagy","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyula","family":"Simon","sequence":"additional","affiliation":[{"name":"Mikromikomed Kft. Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Szentm\u00e1ry","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"},{"name":"Klinik f\u00fcr Augenheilkunde,                         Universit\u00e4tsklinikum des Saarlandes Homburg\/Saar, N\u00e9metorsz\u00e1g"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T06:45:58Z","timestamp":1554014758000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1556\/650.2019.31259"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31259","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]}}}