{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T12:24:55Z","timestamp":1648815895578},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: Most human parechovirus (HPeV, family Picornaviridae) infections are asymptomatic but may cause gastroenteritis in children. New reports show that HPeVs can be associated with severe central nervous system symptoms and sepsis-like syndromes in infants. The clinical significance of HPeVs in Hungary has not been investigated before. Aim: The aim of this study was to detect genotype HPeV in faecal samples of children and analysis of the clinical symptoms. Method: For the detection and genotyping of HPeV strains, reverse transcription\u2013polymerase chain reaction and sequencing methods were used from faecal samples of children with gastroenteritis divided into three groups: group A) hospitalised children younger than 10 years (n = 75); group B) 0\u201312 months infants (n = 237) and group C) children less than 18 years of age with sepsis-like\/neurological symptoms (n = 105) were tested. Results: Three HPeV positive samples (3\/75, 4%) were found in group A, two of them belong to the HPeV type 1, the third was non-typeable. All positive samples were from infants of 7 to 11 months of age. In group B, HPeV was detected in 6.8% (16\/237) of the samples. Five were HPeV1, six were HPeV3 and five were non-typeable. While most of the infants with HPeV1 (4\/5) did not require hospitalisation, 83% of the HPeV3 infected infants (5\/6) did. Five (4.8%) HPeV strains detected from children less than 18 years of age with sepsis-like\/neurological symptoms (group C) belonged to HPeV1 (three) and HPeV3 (two). All positive samples were from hospitalised infants less than 2 months of age. Conclusion: HPeV1 infections are less severe in infants than HPeV3 infections. The leading symptom of HPeV1 was diarrhoea, although in infants less than 1\u20132 months neurological symptoms (somnolence, lassitude) were also present. HPeV3 infections were more common among newborns. The main symptoms of severe HPeV3 infection are: gastroenteritis (7\/8), fever \u226538 \u00b0C (6\/7), loss of appetite (6\/7), rash (4\/7), somnolence\/lassitude (3\/7), sepsis-like syndrome (3\/7) and respiratory symptoms (2\/7). Orv Hetil. 2019; 160(10): 386\u2013395. <\/jats:p>","DOI":"10.1556\/650.2019.31304","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T10:14:41Z","timestamp":1551694481000},"page":"386-395","source":"Crossref","is-referenced-by-count":0,"title":["A hum\u00e1n parechov\u00edrusok klinikai jelent\u0151s\u00e9ge s\u00falyos                     \u00fajsz\u00fcl\u00f6tt- \u00e9s csecsem\u0151kori fert\u0151z\u00e9sekben haz\u00e1nkban"],"prefix":"10.1556","volume":"160","author":[{"given":"\u00c1kos","family":"Boros","sequence":"first","affiliation":[{"name":"Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium, Gastroenter\u00e1lis                     V\u00edrusok Nemzeti Referencia Laborat\u00f3riuma, \u00c1llami N\u00e9peg\u00e9szs\u00e9g\u00fcgyi \u00e9s Tisztiorvosi Szolg\u00e1lat D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete P\u00e9cs"},{"name":"Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai \u00e9s Immunit\u00e1stani                     Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, Orvostudom\u00e1nyi Kar P\u00e9cs, Szigeti \u00fat 12., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zs\u00f3fia","family":"Hamarics","sequence":"additional","affiliation":[{"name":"Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium, Gastroenter\u00e1lis                     V\u00edrusok Nemzeti Referencia Laborat\u00f3riuma, \u00c1llami N\u00e9peg\u00e9szs\u00e9g\u00fcgyi \u00e9s Tisztiorvosi Szolg\u00e1lat D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete P\u00e9cs"},{"name":"Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai \u00e9s Immunit\u00e1stani                     Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, Orvostudom\u00e1nyi Kar P\u00e9cs, Szigeti \u00fat 12., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajnalka","family":"Fenyvesi","sequence":"additional","affiliation":[{"name":"Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium, Gastroenter\u00e1lis                     V\u00edrusok Nemzeti Referencia Laborat\u00f3riuma, \u00c1llami N\u00e9peg\u00e9szs\u00e9g\u00fcgyi \u00e9s Tisztiorvosi Szolg\u00e1lat D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete P\u00e9cs"},{"name":"Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai \u00e9s Immunit\u00e1stani                     Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, Orvostudom\u00e1nyi Kar P\u00e9cs, Szigeti \u00fat 12., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Liptai","sequence":"additional","affiliation":[{"name":"Szent L\u00e1szl\u00f3 K\u00f3rh\u00e1z Telephely, Gyermekinfektol\u00f3giai                     Oszt\u00e1ly, D\u00e9l-pesti Centrum K\u00f3rh\u00e1z \u2013 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"Nyul","sequence":"additional","affiliation":[{"name":"Klinikai K\u00f6zpont, Gyermekgy\u00f3gy\u00e1szati Klinika,                         P\u00e9csi Tudom\u00e1nyegyetem, Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Pankovics","sequence":"additional","affiliation":[{"name":"Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium, Gastroenter\u00e1lis                     V\u00edrusok Nemzeti Referencia Laborat\u00f3riuma, \u00c1llami N\u00e9peg\u00e9szs\u00e9g\u00fcgyi \u00e9s Tisztiorvosi Szolg\u00e1lat D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete P\u00e9cs"},{"name":"Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai \u00e9s Immunit\u00e1stani                     Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, Orvostudom\u00e1nyi Kar P\u00e9cs, Szigeti \u00fat 12., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Reuter","sequence":"additional","affiliation":[{"name":"Region\u00e1lis Virol\u00f3giai Laborat\u00f3rium, Gastroenter\u00e1lis                     V\u00edrusok Nemzeti Referencia Laborat\u00f3riuma, \u00c1llami N\u00e9peg\u00e9szs\u00e9g\u00fcgyi \u00e9s Tisztiorvosi Szolg\u00e1lat D\u00e9l-dun\u00e1nt\u00fali Region\u00e1lis Int\u00e9zete P\u00e9cs"},{"name":"Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai \u00e9s Immunit\u00e1stani                     Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, Orvostudom\u00e1nyi Kar P\u00e9cs, Szigeti \u00fat 12., 7624"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T06:58:07Z","timestamp":1556261887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1556\/650.2019.31304"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31304","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}