{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T23:35:21Z","timestamp":1648510521095},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> The control and planning of the treatment of hypertensive patients need specific attention. As regards concomitant diseases and treatments, glaucoma and the use of eye drops should be taken into consideration. The ingredients of the administered eye drops get through the nasolacrimal canal and can be absorbed by the nasal mucosa. Because of the lack of enterohepatic \u2018first pass\u2019 effect, they can act systemically \u2013 like after intravenous administration. This way they can cause systemic side effects. The authors present a case of a patient, too, who was examined and medically checked regularly for years with negative results because of repeated syncope. It became clear only at the Hypertension Centre that the timolol-containing combined eye drops caused the symptoms. The authors draw attention to the fact that in the case of systemic side effects which can be connected to beta-blocking agents (blood pressure fall, bradycardia, breathing disturbance, depression), the role of the eye drops should be taken into consideration. At the same time, the possibility of the systemic drug interactions should not be forgotten either. The interaction with dihydropyridine-type calcium-channel blockers can be of great importance. In these cases, after consultation with an ophthalmologist, the glaucoma treatment with eye drops containing beta-blockers should be modified. Orv Hetil. 2019; 160(8): 309\u2013313. <\/jats:p>","DOI":"10.1556\/650.2019.31310","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T04:31:51Z","timestamp":1550377911000},"page":"309-313","source":"Crossref","is-referenced-by-count":1,"title":["Ritka sziszt\u00e9m\u00e1s gy\u00f3gyszer-interakci\u00f3: timololtartalm\u00fa                     szemcsepp \u00e9s lerkanidipintabletta egy\u00fcttes alkalmaz\u00e1sa sor\u00e1n ism\u00e9tl\u0151d\u0151en                     jelentkez\u0151 syncope"],"prefix":"10.1556","volume":"160","author":[{"given":"Edit","family":"Kun","sequence":"first","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Szakrendel\u00e9s, D\u00e9l-budai Eg\u00e9szs\u00e9g\u00fcgyi Szolg\u00e1lat Nonprofit Kft. Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00f3r\u00e1nt","family":"Dienes","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Profil, Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Simonyi","sequence":"additional","affiliation":[{"name":"Anyagcsere K\u00f6zpont, Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervin","family":"Finta","sequence":"additional","affiliation":[{"name":"VIP-I Profil, Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316., 1115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T02:46:34Z","timestamp":1554000394000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1556\/650.2019.31310"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31310","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}