{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:27:11Z","timestamp":1789720031309,"version":"4.0.1"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Inrtoduction: Caveolae are flask shaped with 50\u2013100 nm size, non-clathrin associated invaginations of the plasmamembrane. The main membrane protein of the structures is caveolin-1. Caveolae play an important role in numerous cellular functions including vesicular transport and cell-cycle regulation, and create platforms for classical and alternative signaling pathways. According to international studies, caveolae may influence the physiology and pathology of lens epithelial cells. Aim: The aim of the study was to examine and compare the morphology of caveolae and the immunohistochemical difference of caveolin-1 in control (myopic and hyperopic) lens epithelial cells and human lens epithelial cells affected by cataract. Authors investigated whether caveolae might have a role in cataractogenesis. Method: Anterior lens capsules were obtained by capsulorhexis during surgery of senile cataract and refractive surgery of the clear lens. Ultra-fine sections have been studied by transmission electron microscopy, and semi-fine samples were labelled for immunohistochemistry with polyclonal caveolin-1 and cavin-1 antibodies. Results: By immunohistochemistry, in the control group, significant caveolin-1 label with low cavin-1 signal were measured in the lens epithelial cells. In the cataract group high cavin-1 and caveolin-1 expression was detected. In the control group, caveolae were not observed, but in the lens epithelial cells with cataract, increased number of caveolae have been detected by electron microscopy. Conclusions: For the development and maintenance of the specific caveolae shape, caveolin-1 is needed to be accompanied by cavin-1. Therefore, it is presumable that the increased expression of cavin-1 could explain the higher number of caveolae in the cataract group. These results might suggest that caveolae might play a role in cataractogenesis. Orv Hetil. 2019; 160(8): 300\u2013308. <\/jats:p>","DOI":"10.1556\/650.2019.31313","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T09:31:51Z","timestamp":1550395911000},"page":"300-308","source":"Crossref","is-referenced-by-count":4,"title":["Caveol\u00e1k szerepe a sz\u00fcrke h\u00e1lyog k\u00e9pz\u0151d\u00e9s\u00e9ben: hum\u00e1n                     szemlencse epithelsejtjeinek vizsg\u00e1lata"],"prefix":"10.1556","volume":"160","author":[{"given":"M\u00e1rton","family":"Magyar","sequence":"first","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar 1085 Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikt\u00f3ria","family":"Zsiros","sequence":"additional","affiliation":[{"name":"Anat\u00f3miai, Sz\u00f6vet- \u00e9s Fejl\u0151d\u00e9stani Int\u00e9zet,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"L. Kiss","sequence":"additional","affiliation":[{"name":"Anat\u00f3miai, Sz\u00f6vet- \u00e9s Fejl\u0151d\u00e9stani Int\u00e9zet,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n Zsolt","family":"Nagy","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar 1085 Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Szepessy","sequence":"additional","affiliation":[{"name":"Szem\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar 1085 Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T06:46:34Z","timestamp":1554014794000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1556\/650.2019.31313"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31313","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}