{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:14:40Z","timestamp":1785370480010,"version":"3.55.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> In this review article, the authors summarize the clinical aspects of the novel classification of Ehlers\u2013Danlos syndrome, which is a group of rare, hereditary connective tissue disorders. The leading symptom of the Ehlers\u2013Danlos syndrome group is joint hypermobility, skin hyperextensibility and generalized tissue fragility. Ehlers\u2013Danlos syndrome displays a high clinical and genetic heterogeneity and harbors many multidisciplinary properties. Certain subtypes only affect the quality of life, while other forms may lead to severe, even fatal vascular or intestinal complications. Last year, based on the data of various international genotype-phenotype correlation studies of large populations, a new classification of the syndrome\u2019s clinical subtypes was introduced. The novel international nosology of Ehlers\u2013Danlos syndromes published in 2017 delineates 13 clinical subtypes, describes their genetic background and defines major and minor diagnostic criteria for each subtype. We gathered the complex, multidisciplinary symptoms of Ehlers\u2013Danlos syndromes in a table to assist the diagnosis from a differential diagnostic point of view. In the clinical practice, the proper diagnosis of patients affected by the Ehlers\u2013Danlos syndrome group is essential to give optimal clinical care and to prevent the development of severe complications. Orv Hetil. 2019; 160(16): 603\u2013612. <\/jats:p>","DOI":"10.1556\/650.2019.31351","type":"journal-article","created":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T14:26:53Z","timestamp":1555252013000},"page":"603-612","source":"Crossref","is-referenced-by-count":3,"title":["Az Ehlers\u2013Danlos-szindr\u00f3m\u00e1k korszer\u0171 oszt\u00e1lyoz\u00e1sa \u00e9s                     multidiszciplin\u00e1ris t\u00fcnettana"],"prefix":"10.1556","volume":"160","author":[{"given":"Fanni Vir\u00e1g","family":"Ralovich","sequence":"first","affiliation":[{"name":"B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Kiss","sequence":"additional","affiliation":[{"name":"B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"},{"name":"MTA Wigner Fizikai Kutat\u00f3k\u00f6zpont Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarolta","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[{"name":"B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rta","family":"Medvecz","sequence":"additional","affiliation":[{"name":"B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,14]],"date-time":"2019-04-14T14:26:53Z","timestamp":1555252013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1556\/650.2019.31351"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31351","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}