{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T14:30:14Z","timestamp":1722004214090},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: The most recent European guidelines for the treatment of hypertension suggest the use of renin-angiotensin-aldosterone system antagonists (RAAS inhibitors) and calcium channel blockers (CCBs) or diuretics fixed-dose combinations (FDCs) as the first therapeutic option. In antihypertensive therapy, the patient\u2019s adherence is one of the most important factors in reducing unwanted cardiovascular events. Aim: Our aim was to assess the one-year persistence of angiotensin-converting enzyme inhibitor (ACEI) and CCB FDCs in hypertensive patients. Method: Authors have analysed the prescription database of the National Health Insurance Fund in Hungary on pharmacy claims between October 1, 2012 and September 30, 2013. Those patients were identified who filled prescriptions for FDCs of ACEI and CCBs prescribed for the first time for hypertensive patients and who had not received similar drugs during the year before. Apparatus of survival analysis was used, where \u2018survival\u2019 was the time to abandon the medication. Results: 124\u00a0388 patients met the inclusion criteria. One-year persistence rate and hazard ratio (HR) of discontinuation in patients with ramipril\/amlodipine FDC was 54% (HR = 1.00, reference), perindopril\/amlodipine 47% (HR = 1.30, p&lt;0.0001), lisinopril\/amlodipine 36% (HR = 1.79, p&lt;0.0001), ramipril\/felodipine 26% (HR = 2.28, p&lt;0.0001) and trandolapril\/verapamil 12% (HR = 4.13, p&lt;0.0001). The average survival time of drug limited to 360 days was 270.2 days for ramipril\/amlodipine FDC, 242.7 days for perindopril\/amlodipine FDC, 211.2 days for lisinopril\/amlodipine FDC, 186.3 days for ramipril\/felodipine FDC and 125.7 days for trandolapril\/verapamil FDC. Conclusions: The authors demonstrated that the one-year persistence of ACEI\/CCB FDCs was significantly different in hypertensive patients. Ramipril\/amlodipine FDC was more advantageous for patient adherence. Orv Hetil. 2019; 160(9): 343\u2013348. <\/jats:p>","DOI":"10.1556\/650.2019.31355","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:27:17Z","timestamp":1551054437000},"page":"343-348","source":"Crossref","is-referenced-by-count":2,"title":["Az                     angiotenzinkonvert\u00e1l\u00f3enzim-g\u00e1tl\u00f3\/kalciumcsatorna-blokkol\u00f3 fix                     gy\u00f3gyszer-kombin\u00e1ci\u00f3k egy\u00e9ves perzisztenci\u00e1ja hypertoni\u00e1ban"],"prefix":"10.1556","volume":"160","author":[{"given":"G\u00e1bor","family":"Simonyi","sequence":"first","affiliation":[{"name":"Anyagcsere K\u00f6zpont, Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316., 1115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Ferenci","sequence":"additional","affiliation":[{"name":"\u00c9lettani Szab\u00e1lyoz\u00e1sok Csoport, \u00d3budai Egyetem, Neumann J\u00e1nos Informatikai Kar Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ervin","family":"Finta","sequence":"additional","affiliation":[{"name":"Kiemelt Hotelszolg\u00e1lat I., Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Igaz","sequence":"additional","affiliation":[{"name":"Gastroenterologiai Profil, Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ndor","family":"Balogh","sequence":"additional","affiliation":[{"name":"Alapell\u00e1t\u00e1si Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Gasparics","sequence":"additional","affiliation":[{"name":"Anyagcsere K\u00f6zpont, Szent Imre Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Budapest, T\u00e9t\u00e9nyi \u00fat 12\u201316., 1115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mih\u00e1ly","family":"Medvegy","sequence":"additional","affiliation":[{"name":"III. Belgy\u00f3gy\u00e1szat-Kardiol\u00f3giai Oszt\u00e1ly,                         Pest Megyei Fl\u00f3r Ferenc K\u00f3rh\u00e1z Kistarcsa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T01:48:23Z","timestamp":1554947303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1556\/650.2019.31355"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31355","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3]]}}}