{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:03:12Z","timestamp":1785204192791,"version":"3.55.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"32","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: Resecability of liver tumors is exclusively depending on the future liver remnant (FLR). The remnant can be hypertrophised using portal vein occlusion techniques. The latest hypertrophising method is Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS), which provides the most significant induced hypertrophy in the shortest time. Morbidity and mortality of this procedure were initially unacceptably high. Aim: Reducing complications by better patient selection and modified surgical technique. Method: The First Department of Surgery, Semmelweis University, Budapest, prefers the \u2018no touch\u2019 technique, instead of \u2018complete mobilization\u2019. For optimizing patient selection, an international registry (including our patients\u2019 data) was established. In addition to the surgical, we collected demographic, disease, liver function, histology, morbidity (Clavien\u2013Dindo) and mortality parameters. Volume and function measurements were performed by using CT-volumetry and <jats:sup>99m<\/jats:sup>technecium-mebrofenin SPECT\/CT. Data were analyzed by multivariate analysis (significance: p&lt;0.05). Results: We performed 20 ALPPS procedures from 2012 to 2018. The relative volume increment and resectability in our department and among the 320 registry patients were 96% vs. 86% and 95% vs. 98%. Using \u2018no touch\u2019 technique, the Clavien\u2013Dindo III\u2013IV morbidity and mortality rates were significantly lower (22%\u20130%) than with \u2018complete mobilization\u2019 (63%\u201336%) (p&lt;0.05). Based on the multivariate analysis of the registry patients, age over 60 years, liver macrosteatosis, non-colorectal liver tumor, &gt;300 minutes operation time, &gt;2 units of red blood cell transfusion, or insufficient FLR function before stage 2 were identified as independent factors influencing mortality (p&lt;0.05). Conclusion: Mortality and morbidity of ALPPS can be reduced by proper patient selection and \u2018no touch\u2019 surgical technique. Orv Hetil. 2019; 160(32): 1260\u20131269. <\/jats:p>","DOI":"10.1556\/650.2019.31440","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T05:36:50Z","timestamp":1565156210000},"page":"1260-1269","source":"Crossref","is-referenced-by-count":2,"title":["Speci\u00e1lis m\u00e1jm\u0171t\u00e9t (Associating Liver Partition and                     Portal vein ligation for Staged hepatectomy, ALPPS) morbidit\u00e1s\u00e1nak cs\u00f6kkent\u00e9se                     \u00e1t\u00e9rt\u00e9kelt betegkiv\u00e1laszt\u00e1si elvek \u00e9s m\u0171t\u00e9ttechnikai m\u00f3dos\u00edt\u00e1s                     r\u00e9v\u00e9n"],"prefix":"10.1556","volume":"160","author":[{"given":"Oszk\u00e1r","family":"Hahn","sequence":"first","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"B\u00e1rdos","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Kupcsulik","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Szij\u00e1rt\u00f3","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Kokas","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damj\u00e1n","family":"Pekli","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Zsirka-Klein","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibolyka","family":"Dud\u00e1s","sequence":"additional","affiliation":[{"name":"V\u00e1rosmajori Sz\u00edv- \u00e9s \u00c9rgy\u00f3gy\u00e1szati Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Pajor","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Hars\u00e1nyi","sequence":"additional","affiliation":[{"name":"I. Seb\u00e9szeti Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest, \u00dcll\u0151i \u00fat 78., 1087"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T05:36:51Z","timestamp":1565156211000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":0,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1556\/650.2019.31440"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31440","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}