{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:10:12Z","timestamp":1784855412817,"version":"3.55.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: Due to the inappropriate use of antibiotics (AB), more pathogens become multiresistant. One of the most severe sources of sepsis is cholangitis. To avoid fatal outcome, an effective AB policy plays a key role. Aim: To investigate the AB resistance of bacteria causing cholangitis and the efficacy of AB treatment. Patients and method: Microbiological tests of bile samples collected during cholangitis-indicated endoscopic retrograde cholangiopancreatographies were analysed at the First Department of Medicine, University of Szeged, in 2006 and in 2016. Results: 29 and 111 patients had bile sample collection in 2006 and in 2016, respectively. Of that, 22 (75%) and 106 (95%) were positive. Mean age: 61 \u00b1 14 vs. 71 \u00b1 14 years, no difference between men\/women ratio. In 2006, 10 cases empirical AB (ciprofloxacine with metronidazole or imipenem) were used. In 9 cases (90%), the AB was adequate based on the microbiological results. In 2016, in 88 cases empirical AB was applied (ciprofloxacine and metronidazole, ceftriaxone with metronidazole or imipenem with metronidazole). In 29 cases, the empirical AB was ineffective. The efficacy of ciprofloxacine decreased to 64% in 2016. The profile of the most frequent cholangitis-causing pathogens (Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae) was the same, but their resistency against ciprofloxacine increased. The rates of polymicrobal infections were 73% and 63%, respectively. Conclusion: The rates of positive bile samples were significantly higher in 2016. The profile of the most frequent pathogens was the same. The efficacy of the first-choice empirical AB ciprofloxacine decreased in 2016. The types of the most frequent cholangitis-causing bacteria are in line with the ones included in the Tokyo Guideline. Orv Hetil. 2019; 160(36): 1437\u20131442. <\/jats:p>","DOI":"10.1556\/650.2019.31456","type":"journal-article","created":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T04:03:18Z","timestamp":1567828998000},"page":"1437-1442","source":"Crossref","is-referenced-by-count":3,"title":["Az antibiotikumrezisztencia v\u00e1ltoz\u00e1sa cholangitisben.                         <i>Klinikai tapasztalataink<\/i>"],"prefix":"10.1556","volume":"160","author":[{"given":"D\u00f3ra","family":"Ill\u00e9s","sequence":"first","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"Urb\u00e1n","sequence":"additional","affiliation":[{"name":"Klinikai Mikrobiol\u00f3giai Diagnosztikai Int\u00e9zet,                         Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"L\u00e1z\u00e1r","sequence":"additional","affiliation":[{"name":"Klinikai Mikrobiol\u00f3giai Diagnosztikai Int\u00e9zet,                         Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla","family":"Nagy","sequence":"additional","affiliation":[{"name":"K\u00f3rh\u00e1zhigi\u00e9n\u00e9s Oszt\u00e1ly, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emese","family":"Iv\u00e1ny","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Kui","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Lemes","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Tajti","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Czak\u00f3","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Szeged, Kor\u00e1nyi fasor 8\u201310., 6720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T04:03:19Z","timestamp":1567828999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":0,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1556\/650.2019.31456"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31456","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}