{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T05:54:14Z","timestamp":1648792454278},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"38","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Immunglobulin E (IgE)-based, irregularly recurring, severe anaphylactic reactions occurred in a 50-year-old European white male patient suffering also from Crohn\u2019s disease. On the base of immunologic laboratory tests concerning the mechanism of the phenomenon, the idea arose whether molecules derived for certain microbial derivatives could enter the blood circulation via the damaged bowel walls in the patient with Crohn\u2019s disease and they might act as allergens. The microbial analysis diagnosed atypical Staphylococcus in the stool. The serum level of IgE was very high. The concomitant use of targeted antibiotics and anti-allergy and immunosuppressive agents resulted in a complete remission during a couple of months. Not only Crohn\u2019s disease has improved, but also the total serum IgE level has decreased significantly, and the unpredictable anaphylactic attacks have been completely eliminated. In Crohn\u2019s disease, the anaphylactic complications induced by atypical microbial allergens (e.g., derivatives of Staphylococcus) can be effectively treated after the recognition of this pathological mechanism. This is the first description of such a pathologic state. Orv Hetil. 2019; 160(38): 1514\u20131518. <\/jats:p>","DOI":"10.1556\/650.2019.31474","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T08:10:26Z","timestamp":1568967026000},"page":"1514-1518","source":"Crossref","is-referenced-by-count":0,"title":["<i>Staphylococcus<\/i> \u00e1ltal kiv\u00e1ltott,                     immunglobulin-E-alap\u00fa anafilaxi\u00e1s reakci\u00f3k Crohn-betegs\u00e9gben. <i>Egy                         t\u00fcnetegy\u00fcttes els\u0151 le\u00edr\u00e1sa<\/i>"],"prefix":"10.1556","volume":"160","author":[{"given":"\u00c9va","family":"Z\u00f6ld","sequence":"first","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Klinikai Immunol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, M\u00f3ricz Zsigmond \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Barta","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Gasztroenterol\u00f3giai Nem \u00d6n\u00e1ll\u00f3                     Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"},{"name":"Kihelyezett Infektol\u00f3giai Tansz\u00e9k, Ken\u00e9zy Gyula Oktat\u00f3                     K\u00f3rh\u00e1z, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[{"name":"K\u00f3rbonctani Oszt\u00e1ly, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"Solt\u00e9sz","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Angiol\u00f3giai Nem \u00d6n\u00e1ll\u00f3 Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Szegedi","sequence":"additional","affiliation":[{"name":"B\u0151rgy\u00f3gy\u00e1szati Allergia Tansz\u00e9k, B\u0151rgy\u00f3gy\u00e1szati Klinika,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ndor","family":"Sipka","sequence":"additional","affiliation":[{"name":"Belgy\u00f3gy\u00e1szati Int\u00e9zet, Klinikai Immunol\u00f3giai Tansz\u00e9k,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, M\u00f3ricz Zsigmond \u00fat 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T08:10:28Z","timestamp":1568967028000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":0,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1556\/650.2019.31474"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31474","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}