{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:52:56Z","timestamp":1769579576128,"version":"3.49.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"40","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: Despite advancements in diagnostic capabilities and the availability of effective antimicrobial agents, community-acquired infections of the central nervous system (CNS) are still associated with high mortality rates. Aim: To assess the epidemiological and clinical characteristics of community-acquired CNS infections treated in the West Pannonian region between 2010 and 2016. Method: Clinical data of 176 patients were retrospectively analysed in two age cohorts: 15 to 65 and more than 65 years of age. Results: Neuroinfections were found to be bacterial in 81, viral in 91, parasitic in 1 and mixed in 3 cases during the observation period. The most frequent bacterial pathogens isolated were Streptococcus pneumoniae (20%) and Borrelia burgdorferi (16%). The most frequent viral pathogens isolated were tick-borne encephalitis virus (37%), herpes simplex virus (10%) and enterovirus (7%). Aetiology was unknown in 40 percent of all cases. The average incidence rate was 9.8\/100 000 person\/year with a mortality rate of 12%. In the cohort of patients aged &gt;65 years, significantly higher frequencies of immunocompromising factors, lower Glasgow Coma Scale values at admission and confusion were observed (p-values: 0.008, 0.017, and 0.050, respectively). Prognosis was negatively influenced by low Glasgow Coma Scale values at admission (OR = 1.6 CI<jats:sub>95%<\/jats:sub>: 1.3\u20131.9; p&lt;0.001), old age (OR = 6.5 CI<jats:sub>95%<\/jats:sub>: 2.5\u201317.1; p&lt;0.001) and immunodeficiency (OR = 3.1 CI<jats:sub>95%<\/jats:sub>: 1.2\u20138.1; p = 0.019). Conclusions: S. pneumoniae remains the most frequently observed causative bacterial pathogen associated with community-acquired CNS infections. Incidence of tick-borne encephalitis in our county is higher than the national average (2.3 versus 0.35\/100 000 person\/year). Orv Hetil. 2019; 160(40): 1574\u20131583. <\/jats:p>","DOI":"10.1556\/650.2019.31489","type":"journal-article","created":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T01:15:11Z","timestamp":1569719711000},"page":"1574-1583","source":"Crossref","is-referenced-by-count":3,"title":["A feln\u0151ttkori neuroinfekci\u00f3k epidemiol\u00f3giai \u00e9s klinikai                     jellemz\u0151inek vizsg\u00e1lata a nyugat-dun\u00e1nt\u00fali r\u00e9gi\u00f3ban"],"prefix":"10.1556","volume":"160","author":[{"given":"Zsuzsanna","family":"Feh\u00e9r","sequence":"first","affiliation":[{"name":"Infektol\u00f3giai Oszt\u00e1ly, Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Toldy","sequence":"additional","affiliation":[{"name":"Diagnosztikai Int\u00e9zet, P\u00e9cs \u00e9s Kaposv\u00e1ri K\u00e9pz\u00e9si                     K\u00f6zpont, P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar Kaposv\u00e1r, Szent Imre u. 14\/B, 7400"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Schneider","sequence":"additional","affiliation":[{"name":"Infektol\u00f3giai Oszt\u00e1ly, Markusovszky Egyetemi Oktat\u00f3k\u00f3rh\u00e1z Szombathely"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T01:15:53Z","timestamp":1569719753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":0,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1556\/650.2019.31489"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31489","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}