{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:38:09Z","timestamp":1792291089897,"version":"4.4.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"40","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p> Abstract: <\/jats:p><jats:p> Introduction: Liver cirrhosis (20\u201325%), hepatocellular carcinoma (1.5\u20133%), insulin resistance (30\u201340%) and type 2 diabetes (25\u201330%) are common complications in patients with chronic hepatitis C virus (HCV) infection; however, data are missing from Hungary. Aim: To determine the prevalence of diabetes and insulin resistance in Hungarian HCV patients; to evaluate treatment-induced metabolic changes in relation to diabetes\/insulin resistance and virological response and to perform a sustained follow-up for hepatocellular carcinoma detection. Method: We enrolled 150 Hungarian HCV genotype 1 patients (mean age: 48.55 \u00b1 8.55 years, male\/female ratio: 45\/55%) from 2007\u20132012. We analysed their baseline, week 12, and end of therapeutic follow-up (24 weeks after interferon-based therapy completion) laboratory data. We performed a 5-year follow-up (2012\u20132017). Results: The prevalence of insulin sensitivity, insulin resistance and diabetes was 37.4%, 35.3% and 27.3%, respectively. Insulin resistant and diabetic patients showed a decrease in fasting glucose from baseline to end of follow-up (5.47 \u00b1 0.66 vs. 5.08 \u00b1 0.60, p&lt;0.001; 7.90 \u00b1 2.67 vs. 7.04 \u00b1 2.75, p = 0.006), as did both the sustained responder and non-responder groups. Treatment efficacy rate was poor in diabetic vs. insulin sensitive and insulin resistant groups (17% vs. 46% and 40%); insulin sensitivity was not a predictor of virological response. Three participants with diabetes were diagnosed with hepatocellular carcinoma during follow-up by regular ultrasound examinations. Conclusion: Hungarian HCV patients showed high prevalence of diabetes and insulin resistance, though antiviral therapy caused favourable changes in their carbohydrate metabolism. Antiviral therapy was less effective in diabetic patients. Follow-up ultrasound examinations are required for hepatocellular carcinoma in HCV patients, especially those with diabetes. Orv Hetil. 2019; 160(40): 1591\u20131602. <\/jats:p>","DOI":"10.1556\/650.2019.31522","type":"journal-article","created":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T01:15:11Z","timestamp":1569719711000},"page":"1591-1602","source":"Crossref","is-referenced-by-count":3,"title":["2-es t\u00edpus\u00fa diabetes mellitus, inzulinrezisztencia \u00e9s                     m\u00e1jr\u00e1k id\u00fclt hepatitis C-fert\u0151z\u00e9sben. <i>\u00c9szakkelet-magyarorsz\u00e1gi                         adatok<\/i>"],"prefix":"10.1556","volume":"160","author":[{"given":"B\u00e9la","family":"Lombay","sequence":"first","affiliation":[{"name":"Szent Ferenc Tagk\u00f3rh\u00e1z, Gasztroenterol\u00f3gia,                         Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3 K\u00f3rh\u00e1z Miskolc, Csabai kapu 42., 3529"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Szil\u00e1gyi","sequence":"additional","affiliation":[{"name":"Gazdas\u00e1gelm\u00e9leti \u00e9s M\u00f3dszertani Int\u00e9zet, \u00dczleti                     Statisztika \u00e9s El\u0151rejelz\u00e9si Int\u00e9zeti Tansz\u00e9k, Miskolci Egyetem Miskolc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Szalay","sequence":"additional","affiliation":[{"name":"I. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,29]],"date-time":"2019-09-29T01:15:54Z","timestamp":1569719754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":0,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1556\/650.2019.31522"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31522","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}