{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:51Z","timestamp":1787022951662,"version":"build-2736575974"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"41","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Orvosi Hetilap"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:p>Abstract:<\/jats:p>\n                  <jats:p>\n                    Introduction: Genitourinary syndrome of menopause (GSM) affects up to 40\u201357% of postmenopausal women. Intravaginal microablative fractional CO\n                    <jats:sub>2<\/jats:sub>\n                    laser is a new proposal for the management of GSM, although the evidence of safety and efficacy of the procedure appears to be insufficient. Aim: The aim of the study was to assess the efficacy of fractional CO\n                    <jats:sub>2<\/jats:sub>\n                    laser for the treatment of GSM at the Department of Obstetrics and Gynecology of the University of Debrecen. Method: Postmenopausal women with symptoms of GSM underwent three sessions of microablative fractional rejuvenation CO\n                    <jats:sub>2<\/jats:sub>\n                    laser therapy at 4\u20136 weeks intervals. Vaginal health index (VHI) scores were completed before each treatment and at 6 weeks follow-up as an objective measurement and visual analog scale was used to assess subjective complaints. Statistical analysis included Student\u2019s paired two-sampling t-test for the measure of statistical significance using the standard cutoff for significance p&lt;0.05. Results: 51 women participated (mean age 57.0 \u00b1 9.9 y). Average VHI score was 14.0 \u00b1 4.9 before treatment, 15.0 \u00b1 4.7 after the first session, 18.2 \u00b1 4.6 after the second treatment and 19.5 \u00b1 4.9 at follow-up. The improvement of VHI score was statistically significant between all sessions. Average VAS score was 15.6 \u00b1 14.1 before treatment, 9.0 \u00b1 10.8 after the first session, 5.9 \u00b1 9.2 after the second treatment and 3.4 \u00b1 7.5 at follow-up. The improvement of VAS score was statistically also significant between all sessions. Conclusions: Our study suggests that the fractional CO\n                    <jats:sub>2<\/jats:sub>\n                    laser is an effective and safe treatment of symptoms associated with GSM. Orv Hetil. 2019; 160(41): 1617\u20131622.\n                  <\/jats:p>","DOI":"10.1556\/650.2019.31529","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T03:33:07Z","timestamp":1570419187000},"page":"1617-1622","source":"Crossref","is-referenced-by-count":6,"title":["A h\u00fcvelyi CO\n                    <sub>2<\/sub>\n                    -l\u00e9zer-kezel\u00e9s r\u00f6vid t\u00e1v\u00fa                     hat\u00e1sai a menopausalis genitourinalis szindr\u00f3ma t\u00fcneteire"],"prefix":"10.1556","volume":"160","author":[{"given":"Bence","family":"Kozma","sequence":"first","affiliation":[{"name":"Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bert","family":"P\u00f3ka","sequence":"additional","affiliation":[{"name":"Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Sipos","sequence":"additional","affiliation":[{"name":"Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Int\u00e9zet,                         Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1ndor","family":"\u00c1cs","sequence":"additional","affiliation":[{"name":"II. Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika,                         Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar Budapest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of                     Female Pelvic Medicine and Reconstructive Surgery, Eastern Virginia Medical School Norfolk, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"language":"hu","link":[{"URL":"https:\/\/www.akademiai.com\/doi\/pdf\/10.1556\/650.2019.31529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T03:33:10Z","timestamp":1570419190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.akademiai.com\/doi\/10.1556\/650.2019.31529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":0,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1556\/650.2019.31529"],"URL":"https:\/\/doi.org\/10.1556\/650.2019.31529","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10]]}}}