{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T16:54:44Z","timestamp":1783875284702,"version":"3.55.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"8","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>A rosszul differenci\u00e1lt neuroendocrin tumorok k\u00f6z\u00e9 tartozik a j\u00f3l ismert\n                    kissejtes carcinoma, valamint a ritka nagysejtes neuroendocrin carcinoma. A k\u00e9t\n                    daganat hasonl\u00f3 morfol\u00f3giai k\u00e9pe, a betegs\u00e9g agressz\u00edv viselked\u00e9se, illetve a\n                    vitatott kezel\u00e9si aj\u00e1nl\u00e1sok miatt a diagn\u00f3zis fel\u00e1ll\u00edt\u00e1sa \u00e9s a ter\u00e1pia\n                    megv\u00e1laszt\u00e1sa multidiszciplin\u00e1ris megk\u00f6zel\u00edt\u00e9st ig\u00e9nyel. Bal oldali fejf\u00e1j\u00e1s,\n                    h\u00e1nyinger, hom\u00e1lyos l\u00e1t\u00e1s miatt ker\u00fclt felv\u00e9telre az 52 \u00e9ves n\u0151beteg. A\n                    k\u00e9palkot\u00f3 vizsg\u00e1lat bal occipitalisan, illetve a kisagyban metaszt\u00e1zisra gyan\u00fas\n                    k\u00e9pletet \u00e1br\u00e1zolt. Az idegseb\u00e9szeten mindk\u00e9t tumort elt\u00e1vol\u00edtott\u00e1k. A sz\u00f6vettani\n                    vizsg\u00e1lat neuroendocrin carcinoma agyi \u00e1tt\u00e9t\u00e9t igazolta. A mellkas CT-vizsg\u00e1lata\n                    a bal t\u00fcd\u0151ben kontrasztanyagot halmoz\u00f3 k\u00e9pletet igazolt. A bronchoszk\u00f3pos\n                    biopszi\u00e1s minta nagysejtes neuroendocrin carcinom\u00e1t k\u00f3rism\u00e9zett. Posztoperat\u00edv\n                    koponyabesug\u00e1rz\u00e1st \u00e9s a kissejtes t\u00fcd\u0151r\u00e1k protokollja szerinti kemoter\u00e1pi\u00e1t\n                    alkalmaztak. R\u00f6videsen progresszi\u00f3 \u00e9s atelectasia miatt mellkasbesug\u00e1rz\u00e1s\n                    kezd\u0151d\u00f6tt, amelyet ism\u00e9telt agyi \u00e1tt\u00e9tek miatt meg kellett szak\u00edtani. A\n                    kemoter\u00e1pi\u00e1t a nem kissejtes t\u00fcd\u0151r\u00e1k protokollja alapj\u00e1n folytatt\u00e1k. H\u00e1rom h\u00f3nap\n                    ut\u00e1n mellkasi progresszi\u00f3, kisagyi \u00e9s csont\u00e1tt\u00e9tek jelentkeztek. A beteg 14\n                    h\u00f3nap kezel\u00e9s ut\u00e1n elhunyt. A nagysejtes neuroendocrin carcinoma rossz\n                    progn\u00f3zis\u00fa, az esetek 25\u201350%-\u00e1ban agyi \u00e1tt\u00e9tet ad\u00f3 t\u00fcd\u0151daganat. A korai st\u00e1dium\u00fa\n                    nagysejtes neuroendocrin carcinoma eset\u00e9ben a seb\u00e9szeti kezel\u00e9s szerepe\n                    els\u0151dleges, az adjuv\u00e1ns kemoter\u00e1pia m\u00e9rlegelend\u0151. A kemoter\u00e1pia sor\u00e1n a nem\n                    kissejtes t\u00fcd\u0151r\u00e1k protokollja az elfogadott, de az irodalmi adatok alapj\u00e1n a\n                    kissejtes carcinoma kezel\u00e9si s\u00e9m\u00e1ja is m\u00e9rlegelhet\u0151. Orv Hetil. 2020; 161(8):\n                    313\u2013319.<\/jats:p>","DOI":"10.1556\/650.2020.31581","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T15:53:28Z","timestamp":1582127608000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":8,"title":["Nagysejtes neuroendocrin carcinoma \u2013 a k\u00f3risme \u00e9s a kezel\u00e9s neh\u00e9zs\u00e9gei"],"prefix":"10.1556","volume":"161","author":[{"given":"Tam\u00e1s","family":"Zombori","sequence":"first","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetemSzeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9ta","family":"Juh\u00e1sz-Nagy","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetemSzeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Tiszlavicz","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetemSzeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Cserni","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Pathologiai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetemSzeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Fur\u00e1k","sequence":"additional","affiliation":[{"name":"2 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Seb\u00e9szeti Klinika, Szegedi Tudom\u00e1nyegyetemSzeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Szalontai","sequence":"additional","affiliation":[{"name":"3 Csongr\u00e1d Megyei Mellkasi Betegs\u00e9gek Szakk\u00f3rh\u00e1za Deszk"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"P\u00e1lf\u00f6ldi","sequence":"additional","affiliation":[{"name":"3 Csongr\u00e1d Megyei Mellkasi Betegs\u00e9gek Szakk\u00f3rh\u00e1za Deszk"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/8\/article-p313.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/8\/article-p313.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:30Z","timestamp":1633914810000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/8\/article-p313.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":0,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31581","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}