{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T14:48:09Z","timestamp":1698763689539},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>A szerz\u0151k egy multiplex endokrin neoplasia-2A (MEN2A) szindr\u00f3m\u00e1ban szenved\u0151 beteg\n                    eset\u00e9t ismertetik, akin\u00e9l 55 \u00e9ves korban hasi panaszok miatti r\u00e9szletes\n                    kivizsg\u00e1l\u00e1s r\u00e9szek\u00e9nt der\u00fclt f\u00e9ny k\u00e9toldali mell\u00e9kvese-t\u00e9rfoglal\u00e1sra \u00e9s\n                    pajzsmirigyg\u00f6bre. Az ut\u00f3bbi miatt v\u00e9gzett thyreoidectomia sz\u00f6vettani lelete\n                    medullaris pajzsmirigy-carcinom\u00e1t igazolt. A mell\u00e9kvese-t\u00e9rfoglal\u00e1sok hormon- \u00e9s\n                    k\u00e9palkot\u00f3 vizsg\u00e1latok alapj\u00e1n bilater\u00e1lis phaeochromocytom\u00e1nak bizonyultak.\n                    T\u00fcnetmentes primer hyperparathyreosisra is f\u00e9ny der\u00fclt. Laparoszk\u00f3pos\n                    adrenalectomia \u00e9s mell\u00e9kpajzsmirigy-adenoma elt\u00e1vol\u00edt\u00e1sa t\u00f6rt\u00e9nt. A beteg\n                    pozit\u00edv csal\u00e1di anamn\u00e9zise \u00e9s a klinikai k\u00e9p alapj\u00e1n felmer\u00fcl\u0151 MEN2A-szindr\u00f3m\u00e1t\n                    genetikai vizsg\u00e1lattal bizony\u00edtottuk. Az els\u0151fok\u00fa rokonok sz\u0171r\u00e9se sor\u00e1n a beteg\n                    25 \u00e9ves l\u00e1nygyermeke g\u00e9nhordoz\u00f3nak bizonyult, n\u00e1la prevent\u00edv thyreoidectomi\u00e1ra\n                    ker\u00fclt sor, \u00e9s a sz\u00f6vettan t\u00f6bbg\u00f3c\u00fa medullaris carcinom\u00e1t igazolt. Az eset\n                    kapcs\u00e1n a szerz\u0151k \u00e1ttekintik a MEN2A-szindr\u00f3ma klinikai jellemz\u0151it, \u00e9s\n                    hangs\u00falyozz\u00e1k a genetikai vizsg\u00e1lat \u00e9s a csal\u00e1dsz\u0171r\u00e9s fontoss\u00e1g\u00e1t. Orv Hetil.\n                    2020; 161(2): 75\u201379.<\/jats:p>","DOI":"10.1556\/650.2020.31595","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T13:26:27Z","timestamp":1578230787000},"page":"75-79","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["A multiplex endokrin neoplasia-2A szindr\u00f3m\u00e1r\u00f3l egy csal\u00e1d kapcs\u00e1n"],"prefix":"10.1556","volume":"161","author":[{"given":"Ildik\u00f3","family":"Hircsu","sequence":"first","affiliation":[{"name":"1 Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3gia Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annam\u00e1ria","family":"Gazdag","sequence":"additional","affiliation":[{"name":"1 Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3gia Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"Bodor","sequence":"additional","affiliation":[{"name":"1 Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3gia Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Berta","sequence":"additional","affiliation":[{"name":"1 Belgy\u00f3gy\u00e1szati Int\u00e9zet, Endokrinol\u00f3gia Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nika","family":"Andr\u00e1si","sequence":"additional","affiliation":[{"name":"2 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Kany\u00e1ri","sequence":"additional","affiliation":[{"name":"2 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Gy\u0151ry","sequence":"additional","affiliation":[{"name":"2 Seb\u00e9szeti Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ndor","family":"Barna","sequence":"additional","affiliation":[{"name":"3 Nukle\u00e1ris Medicina Tansz\u00e9k, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harjit Pal","family":"Bhattoa","sequence":"additional","affiliation":[{"name":"4 Laborat\u00f3riumi Medicina Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Nagy","sequence":"additional","affiliation":[{"name":"4 Laborat\u00f3riumi Medicina Int\u00e9zet, Debreceni Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarDebrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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