{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:25:38Z","timestamp":1651537538081},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"3","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>\n          <jats:italic>Bevezet\u00e9s:<\/jats:italic> Az autol\u00f3g haemopoeticus \u0151ssejtek transzplant\u00e1ci\u00f3ja\n                    \u00edg\u00e9retes kezel\u00e9si lehet\u0151s\u00e9g egyes malignus \u00e9s nem malignus betegs\u00e9gek k\u00f6r\u00e9ben. A\n                    beavatkoz\u00e1s ugyanakkor sz\u00f6v\u0151dm\u00e9nyekkel j\u00e1rhat, ezek k\u00f6z\u00fcl kiemelked\u0151\n                    fontoss\u00e1g\u00faak a korai, illetve k\u00e9s\u0151i poszttranszplant\u00e1ci\u00f3s szakban fell\u00e9p\u0151\n                    infekci\u00f3k. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A korai (&lt;+100 nap)\n                    poszttranszplant\u00e1ci\u00f3s infekci\u00f3k gyakoris\u00e1g\u00e1nak \u00e9s k\u00f3rokoz\u00f3inak vizsg\u00e1lata,\n                    tov\u00e1bb\u00e1 a hal\u00e1loz\u00e1s rizik\u00f3t\u00e9nyez\u0151inek meghat\u00e1roz\u00e1sa. <jats:italic>M\u00f3dszer:<\/jats:italic> A\n                    2007 \u00e9s 2014 k\u00f6z\u00f6tt int\u00e9zet\u00fcnkben autol\u00f3g haemopoeticus \u0151ssejtek\n                    transzplant\u00e1ci\u00f3j\u00e1val kezelt 699 beteg prospekt\u00edven gy\u0171jt\u00f6tt adatait retrospekt\u00edv\n                    m\u00f3don vizsg\u00e1ltuk \u00e9s dolgoztuk fel. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A 699 beteg\n                    medi\u00e1n \u00e9letkora 56 (interkvartilis tartom\u00e1ny: 43\u201362) \u00e9v, 54%-uk (376 f\u0151) f\u00e9rfi.\n                    25 p\u00e1cienst m\u00e1s centrumba ir\u00e1ny\u00edtottak vissza tov\u00e1bbi gondoz\u00e1sra, 19 beteg\n                    ut\u00e1nk\u00f6vet\u00e9se pedig megszakadt. A betegek 69,8%-\u00e1ban (488 f\u0151) fordult el\u0151\n                    neutropeni\u00e1s l\u00e1z. 96 betegben (13,7%) \u00f6sszesen 102 infekci\u00f3s epiz\u00f3dot\n                    azonos\u00edtottunk. A leggyakrabban \u2013 \u00f6sszesen 49 epiz\u00f3dban \u2013 bacteriaemi\u00e1t\n                    \u00e9szlelt\u00fcnk. Ezek el\u0151fordul\u00e1si medi\u00e1nja 7 (5\u201311) nap volt a transzplant\u00e1ci\u00f3t\n                    k\u00f6vet\u0151en. A bacteriaemi\u00e1k d\u00f6nt\u0151 t\u00f6bbs\u00e9ge (33\/49) a megtapad\u00e1s el\u0151tt l\u00e9pett fel.\n                    Incidenci\u00e1juk a malignus lymphom\u00e1ban szenved\u0151 betegek eset\u00e9ben szignifik\u00e1nsan\n                    magasabb volt, mint a plazmasejt-rendelleness\u00e9gekben szenved\u0151 csoportban (p =\n                    0,0005, OR: 2,41, 95% CI: 1,49\u20133,99). V\u00edrusfert\u0151z\u00e9s 12, m\u00edg bizony\u00edtott vagy\n                    val\u00f3sz\u00edn\u0171 invaz\u00edv gombainfekci\u00f3 8 alkalommal k\u00f6vetkezett be. A\n                    poszttranszplant\u00e1ci\u00f3s +100 napig k\u00f6vetett 655 p\u00e1ciensn\u00e9l a k\u00f3rh\u00e1zi hal\u00e1loz\u00e1s\n                    2,4% (16 f\u0151) volt, amelyb\u0151l 8 hal\u00e1leset infekci\u00f3s sz\u00f6v\u0151dm\u00e9nnyel \u00e1llt\n                    \u00f6sszef\u00fcgg\u00e9sben. A korai infekci\u00f3k kedvez\u0151tlen\u00fcl befoly\u00e1solt\u00e1k a t\u00fal\u00e9l\u00e9st (p =\n                    0,0001). <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Autol\u00f3g\u0151ssejt-transzplant\u00e1ltakban az\n                    ismeretlen eredet\u0171, neutropeni\u00e1s l\u00e1z gyakori. A dokument\u00e1lt bacteriaemi\u00e1k ar\u00e1nya\n                    azonban alacsony. A plazmasejtes alapbetegs\u00e9g miatt kezeltekhez k\u00e9pest a\n                    lymphom\u00e1s betegekben nagyobb val\u00f3sz\u00edn\u0171s\u00e9ggel l\u00e9p fel bacteriaemia. A korai\n                    infekci\u00f3k rontj\u00e1k a t\u00fal\u00e9l\u00e9s es\u00e9lyeit, \u00edgy megel\u0151z\u00e9s\u00fck \u00e9s hat\u00e9kony kezel\u00e9s\u00fck\n                    tov\u00e1bbra is kiemelt fontoss\u00e1g\u00fa. Orv Hetil. 2020; 161(3): 103\u2013109.<\/jats:p>","DOI":"10.1556\/650.2020.31638","type":"journal-article","created":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T07:31:02Z","timestamp":1578814262000},"page":"103-109","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Autol\u00f3g\u0151ssejt-transzplant\u00e1ci\u00f3t k\u00f6vet\u0151 korai infekci\u00f3k epidemiol\u00f3gi\u00e1ja. Egy hazai centrumban kezelt 699 beteg adatainak elemz\u00e9se"],"prefix":"10.1556","volume":"161","author":[{"given":"Botond","family":"Lakatos","sequence":"first","affiliation":[{"name":"1 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Infektol\u00f3giai Oszt\u00e1ly, D\u00e9l-pesti Centrumk\u00f3rh\u00e1zBudapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helga","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"2 Radiol\u00f3giai \u00e9s Onkoter\u00e1pi\u00e1s Klinika, Semmelweis EgyetemBudapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"Csord\u00e1s","sequence":"additional","affiliation":[{"name":"3 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Gyermekhematol\u00f3giai \u00e9s \u0150ssejt-transzplant\u00e1ci\u00f3s Oszt\u00e1ly, D\u00e9l-pesti Centrumk\u00f3rh\u00e1zBudapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Tatai","sequence":"additional","affiliation":[{"name":"4 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Semmelweis EgyetemBudapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radka","family":"Nikolova","sequence":"additional","affiliation":[{"name":"5 Orsz\u00e1gos Hematol\u00f3giai \u00e9s Infektol\u00f3giai Int\u00e9zet, Mikrobiol\u00f3giai Laborat\u00f3rium, D\u00e9l-pesti Centrumk\u00f3rh\u00e1zBudapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Csomor","sequence":"additional","affiliation":[{"name":"6 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. 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