{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:46:37Z","timestamp":1763642797198},"reference-count":1,"publisher":"Akademiai Kiado Zrt.","issue":"6","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>A pulmonalis arterialis intimalis sarcoma ritka, magas mortalit\u00e1s\u00fa daganat, mely\n                    lokaliz\u00e1ci\u00f3ja miatt a pulmonalis embolia, valamint a t\u00fcd\u0151gyullad\u00e1s t\u00fcnettan\u00e1t\n                    ut\u00e1nozhatja. A diagn\u00f3zis fel\u00e1ll\u00edt\u00e1sa \u00e9s a megfelel\u0151 kezel\u00e9s kiv\u00e1laszt\u00e1sa k\u00f6r\u00fcl\n                    sz\u00e1mos k\u00e9rd\u00e9s mer\u00fclhet fel. Egy 46 \u00e9ves, kor\u00e1bban hereseminoma, pulmonalis\n                    embolia, asztma, valamint pollenallergia miatt kezel\u00e9s alatt \u00e1ll\u00f3 f\u00e9rfi kontroll\n                    mellkasi CT-felv\u00e9tel\u00e9n bal oldalon a mediastinalis pleur\u00e1t infiltr\u00e1l\u00f3, az\n                    arteria pulmonalist teljesen elz\u00e1r\u00f3, \u00f6sszess\u00e9g\u00e9ben 7\u20138 cm-es t\u00e9rfoglal\u00f3\n                    folyamatot \u00edrtak le. A h\u00f6rg\u0151biopszi\u00e1s mint\u00e1b\u00f3l ors\u00f3sejtes tumor diagn\u00f3zisa\n                    sz\u00fcletett, illetve leiomyoma, leiomyomatosus hyperplasia, illetve leiomyosarcoma\n                    lehet\u0151s\u00e9g\u00e9t vetett\u00e9k fel. A fenn\u00e1ll\u00f3 obstrukci\u00f3 miatt a beteg bal oldali\n                    t\u00fcd\u0151elt\u00e1vol\u00edt\u00e1son esett \u00e1t. A sz\u00f6vettani vizsg\u00e1lat a pulmonalis art\u00e9ri\u00e1kban\n                    terjed\u0151, ors\u00f3sejtes daganatot k\u00f3rism\u00e9zett, immunhisztok\u00e9miailag diff\u00faz SMA- \u00e9s\n                    fok\u00e1lis MDM2-pozitivit\u00e1ssal, valamint magas prolifer\u00e1ci\u00f3s aktivit\u00e1ssal. A\n                    h-caldesmon, az S100 protein, az ERG, valamint a pancitokeratin-immunfest\u00e9sek\n                    negat\u00edvnak bizonyultak. Fluoreszcens <jats:italic>in situ<\/jats:italic> hibridiz\u00e1ci\u00f3val a\n                    tumorsejtek mintegy 10%-\u00e1ban polysomi\u00e1t, illetve MDM2-amplifik\u00e1ci\u00f3t lehetett\n                    igazolni, aminek alapj\u00e1n a \u201ehigh-grade\u201d pulmonalis arterialis intimalis sarcoma\n                    diagn\u00f3zisa meger\u0151s\u00edt\u00e9sre ker\u00fclt. F\u00e9l\u00e9ves k\u00f6vet\u00e9s alatt a betegs\u00e9g nem \u00fajult ki.\n                    A pulmonalis arterialis intimalis sarcoma pontos incidenci\u00e1ja nem ismert. Egyes\n                    forr\u00e1sok szerint a kr\u00f3nikus pulmonalis hypertoni\u00e1s betegek 1\u20134%-\u00e1n\u00e1l fordul el\u0151.\n                    A t\u00fcnetek k\u00f6z\u00fcl a fogy\u00e1s kelti fel a legink\u00e1bb a daganatos betegs\u00e9g gyan\u00faj\u00e1t. A\n                    k\u00e9palkot\u00f3 \u00e9s a k\u00f3rsz\u00f6vettani vizsg\u00e1latoknak kulcsszerep\u00fck van a diagn\u00f3zis\n                    fel\u00e1ll\u00edt\u00e1s\u00e1ban. A daganat rossz k\u00f3rj\u00f3slata miatt a min\u00e9l kor\u00e1bbi felismer\u00e9s \u00e9s a\n                    kemoter\u00e1pi\u00e1val kombin\u00e1lt seb\u00e9szi kezel\u00e9s jav\u00edthatja a t\u00fal\u00e9l\u00e9si lehet\u0151s\u00e9geket.\n                    Orv Hetil. 2020; 161(6): 232\u2013236.<\/jats:p>","DOI":"10.1556\/650.2020.31642","type":"journal-article","created":{"date-parts":[[2020,2,2]],"date-time":"2020-02-02T13:50:17Z","timestamp":1580651417000},"page":"232-236","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["A t\u00fcd\u0151art\u00e9ri\u00e1k intim\u00e1j\u00e1b\u00f3l kiindul\u00f3 sarcoma"],"prefix":"10.1556","volume":"161","author":[{"given":"Anita","family":"Sejben","sequence":"first","affiliation":[{"name":"1 Pathologiai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarSzeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Tiszlavicz","sequence":"additional","affiliation":[{"name":"1 Pathologiai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarSzeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Fur\u00e1k","sequence":"additional","affiliation":[{"name":"2 Seb\u00e9szeti Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarSzeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Boros","sequence":"additional","affiliation":[{"name":"3 Csongr\u00e1d Megyei Mellkasi Betegs\u00e9gek Szakk\u00f3rh\u00e1za Szeged"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"S\u00e1pi","sequence":"additional","affiliation":[{"name":"4 I. Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet, Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarBudapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Zombori","sequence":"additional","affiliation":[{"name":"1 Pathologiai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi KarSzeged, \u00c1llom\u00e1s u. 1., 6725"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"R4","doi-asserted-by":"publisher","DOI":"10.23937\/2378-3516\/1410083"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/6\/article-p232.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/6\/article-p232.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:12:20Z","timestamp":1633914740000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/6\/article-p232.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":1,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31642","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}