{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T23:28:32Z","timestamp":1649028512711},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"5","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>Az 1-es t\u00edpus\u00fa diabetes mortalit\u00e1sa, b\u00e1r cs\u00f6kken\u0151 tendenci\u00e1t mutatva, jelent\u0151sen\n                    meghaladja a standard mortalit\u00e1st. Ez egy\u00fattal a diabetesszel meg\u00e9lt \u00e9let\u00e9vek\n                    r\u00f6vid\u00fcl\u00e9s\u00e9vel j\u00e1r egy\u00fctt. Az esetismertet\u00e9s t\u00e1rgya egy 86 \u00e9ves diabetestartammal\n                    a 91. \u00e9let\u00e9v\u00e9t meg\u00e9l\u0151 n\u0151beteg, akit t\u00f6bb mint 55 \u00e9ven kereszt\u00fcl egyetlen orvos \u2013\n                    a szerz\u0151 \u2013 kezelt\/gondozott. Az 1932-ben, \u00f6t\u00e9ves kor\u00e1ban fell\u00e9pett diabetest\n                    el\u0151sz\u00f6r naponta h\u00e1romszor adagolt gyors hat\u00e1s\u00fa inzulinnal, majd 1940-t\u0151l kezdve\n                    naponta egyszer alkalmazott gyors hat\u00e1s\u00fa \u00e9s cink-protamin inzulinnal, k\u00e9s\u0151bb\n                    sert\u00e9s, majd hum\u00e1n krist\u00e1lyos cinkinzulinnal, majd az utols\u00f3 16 \u00e9vben gyors\n                    hat\u00e1s\u00fa NPH-inzulin kever\u00e9k\u00e9vel kezelt\u00e9k. Ennek oka az volt, hogy a beteg\n                    r\u00f6geszm\u00e9sen ragaszkodott a napi egyszeri inzulinad\u00e1shoz, \u00e9s hogy eset\u00e9ben\n                    mindegyik inzulin hat\u00e1startama 24 \u00f3r\u00e1snak bizonyult. Az \u00e9vtizedeken \u00e1t\n                    folyamatosan t\u00faladagolt egyszeri inzulinad\u00e1s k\u00f6vetkezm\u00e9nye a szinte naponta,\n                    f\u0151k\u00e9nt az \u00e9jjeli \u00f3r\u00e1kban fell\u00e9p\u0151 hypoglykaemia lett, k\u00f6vetkezm\u00e9nyes nagyfok\u00fa\n                    v\u00e9rcukor-ingadoz\u00e1sokkal. Az 1930-as \u00e9vek k\u00f6zep\u00e9t\u0151l a hatvanas \u00e9vekig\n                    polarimetri\u00e1s, majd sz\u00e1raz k\u00e9mi\u00e1s m\u00f3dszerrel vizeletcukor-\u00f6nellen\u0151rz\u00e9st v\u00e9gzett\n                    a nyolcvanas \u00e9vek elej\u00e9ig, majd \u00e1tt\u00e9rt a v\u00e9rcukor-\u00f6nellen\u0151rz\u00e9sre. Az \u00f6tvenes\n                    \u00e9vekben k\u00e9t sikertelen terhess\u00e9ge volt, 2010\u201311-ben egym\u00e1s ut\u00e1n jobb, majd bal\n                    oldali combnyakt\u00f6r\u00e9st szenvedett, majd mindk\u00e9t szem\u00e9n megm\u0171t\u00f6tt\u00e9k a\n                    cataract\u00e1j\u00e1t. Az utols\u00f3 25 \u00e9vben HbA<jats:sub>1c<\/jats:sub>-szintje 7% k\u00f6r\u00fcl mozgott. Sem\n                    retinopathia, sem nephropathia nem fejl\u0151d\u00f6tt ki n\u00e1la, csup\u00e1n s\u00falyos neuropathia\n                    okozott panaszokat az utols\u00f3 \u00e9vekben. Emellett id\u0151skori sz\u00e1raz\n                    maculadegenerati\u00f3ja miatt l\u00e1t\u00e1sa folyamatosan romlott. Elnyerte a \u2019Joslin 75\u2019\n                    med\u00e1lt is. \u00c9lete utols\u00f3 k\u00e9t h\u00f3napj\u00e1ban engedte, hogy degludek + glulizin\n                    inzulinnal intenz\u00edven kezelj\u00e9k. Hal\u00e1l\u00e1t myocardialis infarctus okozta. B\u00e1r a\n                    v\u00e9rcukor-ingadoz\u00e1sok minimaliz\u00e1l\u00e1sa \u00e9s a tart\u00f3san j\u00f3 anyagcsere-vezet\u00e9s\n                    jelent\u0151sen jav\u00edtja a diabetesesek \u00e9letkil\u00e1t\u00e1sait, eset\u00fcnkben j\u00f3 f\u00e9l \u00e9vsz\u00e1zadon\n                    kereszt\u00fcl egyik sem \u00e1llt fenn. Ez\u00e9rt az extr\u00e9m hossz\u00fa diabetestartamra nem\n                    tal\u00e1ltunk magyar\u00e1zatot. Orv Hetil. 2020; 161(5): 193\u2013197.<\/jats:p>","DOI":"10.1556\/650.2020.31663","type":"journal-article","created":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T11:02:22Z","timestamp":1580036542000},"page":"193-197","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Extr\u00e9m hossz\u00fa tartam\u00fa 1-es t\u00edpus\u00fa diabetes mellitus ritka esete"],"prefix":"10.1556","volume":"161","author":[{"given":"J\u00f3zsef","family":"F\u00f6v\u00e9nyi","sequence":"first","affiliation":[{"name":"Diabetes Szakrendel\u0151, P\u00e9terfy S\u00e1ndor Utcai K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet \u00e9s Manninger Jen\u0151 Orsz\u00e1gos Traumatol\u00f3giai Int\u00e9zetBudapest, P\u00e9terfy S\u00e1ndor u. 8\u201320., 1076"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/5\/article-p193.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/5\/article-p193.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:14:19Z","timestamp":1633914859000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/5\/article-p193.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31663","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}