{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:26:38Z","timestamp":1785529598298,"version":"3.56.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"13","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>A porckorongs\u00e9rvhez \u00e9s a gerincoszlop egy\u00e9b degenerat\u00edv elv\u00e1ltoz\u00e1saihoz t\u00e1rsul\u00f3\n                    lumbalis-lumbosacralis f\u00e1jdalom patogenezis\u00e9ben szerepet j\u00e1tszik a gyullad\u00e1s, \u00e9s\n                    felt\u00e9telezhet\u0151, hogy ilyen esetekben egyes gyullad\u00e1sos medi\u00e1torok szintje\n                    m\u00e9rhet\u0151en megemelkedik a v\u00e9rben. A v\u00e9rben m\u00e9rhet\u0151 pro- \u00e9s antiinflammatorikus\n                    citokinek, kemokinek, egy\u00e9b szab\u00e1lyoz\u00f3molekul\u00e1k \u00e9s a lumbalis-lumbosacralis\n                    f\u00e1jdalom k\u00f6z\u00f6tti \u00f6sszef\u00fcgg\u00e9seket \u00e9rt\u00e9kel\u0151 vizsg\u00e1latok nagyr\u00e9szt kr\u00f3nikus\n                    der\u00e9kf\u00e1jdalomban szenved\u0151k csoportj\u00e1ban t\u00f6rt\u00e9ntek, az akut \u00e1llapotban m\u00e9rhet\u0151\n                    biomarkerekkel kevesebb vizsg\u00e1lat foglalkozott. Az eddigi vizsg\u00e1latok alapj\u00e1n a\n                    proinflammatorikus TNF\u03b1, IL6, \u00e9s IL8 \u00e9s az antiinflammatorikus IL4 \u00e9s IL10\n                    citokinek j\u00e1tszanak fontos szerepet a discusherniati\u00f3t k\u00f6vet\u0151 gyullad\u00e1sos\n                    v\u00e1laszban. A szem\u00e9lyre szabott medicina szempontjai szerint fontos lehet az akut\n                    betegcsoporton bel\u00fcl alcsoportokat l\u00e9trehozni az etiol\u00f3gia, a progn\u00f3zis \u00e9s a\n                    kezel\u00e9s szempontj\u00e1b\u00f3l. Amennyiben a k\u00fcl\u00f6nb\u00f6z\u0151 proinflammatorikus citokinek\n                    seg\u00edts\u00e9g\u00e9vel azonos\u00edthat\u00f3 lenne egy betegcsoport, amelyn\u00e9l a f\u00e1jdalom h\u00e1tter\u00e9ben\n                    a gyullad\u00e1s a vezet\u0151 ok, akkor ezen betegcsoport val\u00f3sz\u00edn\u0171leg hat\u00e1sosan\n                    kezelhet\u0151 lenne k\u00fcl\u00f6nb\u00f6z\u0151 gyullad\u00e1scs\u00f6kkent\u0151 k\u00e9sz\u00edtm\u00e9nyekkel. A TNF\u03b1-inhibitorok\n                    \u00e9s az IL6-inhibitorok hat\u00e1soss\u00e1g\u00e1t lumbalis-lumbosacralis f\u00e1jdalomban\n                    kontroll\u00e1lt vizsg\u00e1latokban m\u00e1r elemezt\u00e9k, de tov\u00e1bbi tanulm\u00e1nyokra van sz\u00fcks\u00e9g.\n                    A spinalis degener\u00e1ci\u00f3 \u00e9s az akut lumbalis-lumbosacralis f\u00e1jdalom biomarkereinek\n                    meghat\u00e1roz\u00e1sa a j\u00f6v\u0151ben a szem\u00e9lyre szabott ell\u00e1t\u00e1s r\u00e9sz\u00e9t k\u00e9pezheti.\n                    Tiszt\u00e1z\u00e1sra v\u00e1r, hogy a gyullad\u00e1s a der\u00e9kf\u00e1jdalom melyik szakasz\u00e1ban \u00e9s milyen\n                    m\u00e9rt\u00e9kben van jelen, ez milyen m\u00f3dszerekkel m\u00e9rhet\u0151, \u00e9s vannak-e prognosztikus\n                    \u00e9rt\u00e9k\u0171 biomarkerek. Orv Hetil. 2020; 161(13): 483\u2013490.<\/jats:p>","DOI":"10.1556\/650.2020.31665","type":"journal-article","created":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T06:20:35Z","timestamp":1584858035000},"page":"483-490","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":9,"title":["Sz\u00e9rumbiomarkerek akut lumbalis-lumbosacralis f\u00e1jdalomban"],"prefix":"10.1556","volume":"161","author":[{"given":"Kitti","family":"D\u00e9nes","sequence":"first","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika, Semmelweis EgyetemBudapest, Balassa u. 6., 1083"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Ar\u00e1nyi","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika, Semmelweis EgyetemBudapest, Balassa u. 6., 1083"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Csillik","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika, Semmelweis EgyetemBudapest, Balassa u. 6., 1083"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdolna","family":"Sim\u00f3","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika, Semmelweis EgyetemBudapest, Balassa u. 6., 1083"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3bert","family":"Debreczeni","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika, Semmelweis EgyetemBudapest, Balassa u. 6., 1083"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1rcisz","family":"Tegze","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika, Semmelweis EgyetemBudapest, Balassa u. 6., 1083"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"Bereczki","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Neurol\u00f3giai Klinika, Semmelweis EgyetemBudapest, Balassa u. 6., 1083"},{"name":"2 Neuroepidemiol\u00f3giai Kutat\u00f3csoport, MTA\u2013SEBudapest"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/13\/article-p483.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/13\/article-p483.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:14:23Z","timestamp":1633914863000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/13\/article-p483.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":0,"journal-issue":{"issue":"13"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31665","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}