{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:41:46Z","timestamp":1785462106298,"version":"3.56.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"12","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>A kinureninek manaps\u00e1g intenz\u00edv \u00e9rdekl\u0151d\u00e9s t\u00e1rgy\u00e1t k\u00e9pezik, mivel sz\u00e1mos\n                    fiziol\u00f3gi\u00e1s \u00e9s patol\u00f3gi\u00e1s folyamatban r\u00e9szt vesznek. Az esszenci\u00e1lis aminosav\n                    triptof\u00e1n els\u0151sorban a kinurenin-\u00fatvonalon kereszt\u00fcl metaboliz\u00e1l\u00f3dik. A leboml\u00e1s\n                    sor\u00e1n kinurenin-aminotranszfer\u00e1zok seg\u00edts\u00e9g\u00e9vel keletkezik az egyik fontos\n                    term\u00e9k, a kinur\u00e9nsav. A kinur\u00e9nsav excitatorikus receptorok ligandja,\n                    neuroprotekt\u00edv tulajdons\u00e1g\u00fa. A kinur\u00e9nsav szintj\u00e9nek abnorm\u00e1lis cs\u00f6kken\u00e9se vagy\n                    n\u00f6veked\u00e9se a neurotranszmitter-rendszerek egyens\u00faly\u00e1nak felborul\u00e1s\u00e1hoz vezethet,\n                    \u00e9s ez sz\u00e1mos neurodegenerat\u00edv \u00e9s neuropszichi\u00e1triai betegs\u00e9gben megfigyelhet\u0151. A\n                    kinur\u00e9nsav a pol\u00e1ros szerkezete miatt nehezen jut \u00e1t a v\u00e9r\u2013agy-g\u00e1ton, emiatt\n                    k\u00f6zvetlen\u00fcl nem alkalmas ter\u00e1pi\u00e1s c\u00e9lokra. Ez\u00e9rt kutat\u00e1sunk c\u00e9lja olyan\n                    kinur\u00e9nsav-anal\u00f3gok el\u0151\u00e1ll\u00edt\u00e1sa \u00e9s farmakol\u00f3giai tesztel\u00e9se volt, melyek a\n                    v\u00e9r\u2013agy-g\u00e1ton k\u00f6nnyebben \u00e1tjutnak. Az \u00fajonnan szintetiz\u00e1lt kinur\u00e9nsav-anal\u00f3gok\n                    hat\u00e9konynak bizonyultak t\u00f6bb idegrendszeri betegs\u00e9g (migr\u00e9n, Huntington-k\u00f3r)\n                    modellj\u00e9ben. A kinur\u00e9nsav-sz\u00e1rmaz\u00e9kokkal kapott eredm\u00e9nyek szerint e vegy\u00fcletek\n                    \u00faj ter\u00e1pi\u00e1s c\u00e9lpontot jelenthetnek a neurodegenerat\u00edv betegs\u00e9gek kezel\u00e9s\u00e9ben.\n                    Kutat\u00e1si eredm\u00e9nyeink alapj\u00e1n sz\u00e1mos szabadalmi bejelent\u00e9st beny\u00fajtottunk. Orv\n                    Hetil. 2020; 161(12): 443\u2013451.<\/jats:p>","DOI":"10.1556\/650.2020.31673","type":"journal-article","created":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T08:38:49Z","timestamp":1584261529000},"page":"443-451","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["Kinureninek \u00e9s gy\u00f3gyszerkutat\u00e1s"],"prefix":"10.1556","volume":"161","author":[{"given":"Fanni","family":"T\u00f3th","sequence":"first","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, Interdiszciplin\u00e1ris Kiv\u00e1l\u00f3s\u00e1gi K\u00f6zpont, Neurol\u00f3giai Klinika, Szegedi Tudom\u00e1nyegyetemSzeged, Semmelweis u. 6., 6725"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"3 Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar, Interdiszciplin\u00e1ris Kiv\u00e1l\u00f3s\u00e1gi K\u00f6zpont, Gy\u00f3gyszerk\u00e9miai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetemSzeged"},{"name":"4 Sztereok\u00e9miai Kutat\u00f3csoport, MTA\u2013SZTESzeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Szatm\u00e1ri","sequence":"additional","affiliation":[{"name":"3 Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar, Interdiszciplin\u00e1ris Kiv\u00e1l\u00f3s\u00e1gi K\u00f6zpont, Gy\u00f3gyszerk\u00e9miai Int\u00e9zet, Szegedi Tudom\u00e1nyegyetemSzeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Toldi","sequence":"additional","affiliation":[{"name":"5 Term\u00e9szettudom\u00e1nyi \u00e9s Informatikai Kar, Biol\u00f3gia Int\u00e9zet, \u00c9lettani, Szervezettani \u00e9s Idegtudom\u00e1nyi Tansz\u00e9k, Szegedi Tudom\u00e1nyegyetemSzeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"D\u00e9k\u00e1ny","sequence":"additional","affiliation":[{"name":"6 Term\u00e9szettudom\u00e1nyi \u00e9s Informatikai Kar, Interdiszciplin\u00e1ris Kiv\u00e1l\u00f3s\u00e1gi K\u00f6zpont, K\u00e9miai Int\u00e9zet, Fizikai K\u00e9miai \u00e9s Anyagtudom\u00e1nyi Tansz\u00e9k, Szegedi Tudom\u00e1nyegyetemSzeged"},{"name":"7 Biomimetikus Rendszerek Kutat\u00f3csoport, MTA\u2013SZTESzeged"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"V\u00e9csei","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent-Gy\u00f6rgyi Albert Klinikai K\u00f6zpont, Interdiszciplin\u00e1ris Kiv\u00e1l\u00f3s\u00e1gi K\u00f6zpont, Neurol\u00f3giai Klinika, Szegedi Tudom\u00e1nyegyetemSzeged, Semmelweis u. 6., 6725"},{"name":"2 Idegtudom\u00e1nyi Kutat\u00f3csoport, MTA\u2013SZTESzeged"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/12\/article-p443.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/12\/article-p443.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:46Z","timestamp":1633914826000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/12\/article-p443.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":0,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31673","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}