{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:16:43Z","timestamp":1788175003676,"version":"build-2803163510"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"16","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n        <jats:p>\n          <jats:italic>Bevezet\u00e9s:<\/jats:italic> A trimetazidin olyan metabolikus hat\u00e1s\u00fa anyag,\n                    amelynek hat\u00e9konys\u00e1ga igazol\u00e1st nyert a stabil koszor\u00fa\u00e9r-szindr\u00f3ma kezel\u00e9s\u00e9ben.\n                    Az aj\u00e1nl\u00e1s szerint a trimetazidin m\u00e1sodik vonalbeli kezel\u00e9sk\u00e9nt megfontoland\u00f3 az\n                    angina gyakoris\u00e1g\u00e1nak cs\u00f6kkent\u00e9s\u00e9re \u00e9s a terhel\u00e9si tolerancia jav\u00edt\u00e1s\u00e1ra azokban\n                    a betegekben, akiknek a t\u00fcnetei nem kontroll\u00e1lhat\u00f3k megfelel\u0151en b\u00e9ta-blokkol\u00f3k,\n                    kalciumcsatorna-blokkol\u00f3k \u00e9s tart\u00f3s nitr\u00e1tok ad\u00e1sa mellett.\n                        <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Jelen vizsg\u00e1latunkban a k\u00fcl\u00f6nb\u00f6z\u0151 adagol\u00e1s\u00fa (3\n                    \u00d7 20 mg, 2 \u00d7 35 mg, 1 \u00d7 80 mg) trimetazidink\u00e9sz\u00edtm\u00e9nyek hat\u00e9konys\u00e1g\u00e1t k\u00edv\u00e1ntuk\n                    tiszt\u00e1zni stabil angina pectorisban. Az els\u0151dleges klinikai c\u00e9lv\u00e1ltoz\u00f3k a\n                    k\u00f6vetkez\u0151k voltak: heti anginasz\u00e1m, valamint a heti r\u00f6vid hat\u00e1startam\u00fa\n                    sublingualis nitr\u00e1tfogyaszt\u00e1s. <jats:italic>M\u00f3dszer:<\/jats:italic> Mindketten adatgy\u0171jt\u00e9st\n                    v\u00e9gezt\u00fcnk a PubMed, a Cochrane Library \u00e9s a Cochrane Central Register of\n                    Controlled Trials adatb\u00e1zisokban az 1967-t\u0151l 2019. szeptember 30-ig terjed\u0151\n                    id\u0151szakra vonatkoz\u00f3an. A statisztikai elemz\u00e9st standard\n                    metaanal\u00edzis-m\u00f3dszerekkel hajtottuk v\u00e9gre. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> \u00d6sszesen\n                    31 randomiz\u00e1lt, kontroll\u00e1lt, illetve obszerv\u00e1ci\u00f3s tanulm\u00e1ny ker\u00fclt bevon\u00e1sra.\n                    9856 beteg (\u00e1tlag\u00e9letkor: 59,6 \u00e9v, f\u00e9rfi: 61,6%) kezel\u00e9s\u00e9t \u00e9rt\u00e9kelt\u00fck. A\n                    trimetazidin a randomiz\u00e1lt tanulm\u00e1nyokban a placeb\u00f3val \u00f6sszehasonl\u00edtva\n                    cs\u00f6kkentette a heti anginasz\u00e1mot (\u00e1tlagos k\u00fcl\u00f6nbs\u00e9g: \u20131,84, 95% CI: \u20132,39;\n                    \u20131,30; p&lt;0,0001) \u00e9s a heti nitroglicerin-fogyaszt\u00e1st (\u20131,65, 95% CI: \u20132,17;\n                    \u20131,14; p&lt;0,0001). A trimetazidin a kiindul\u00e1shoz k\u00e9pest a kombin\u00e1ci\u00f3s \u00e9s az\n                    obszerv\u00e1ci\u00f3s vizsg\u00e1latokban cs\u00f6kkentette a heti anginasz\u00e1mot (\u00e1tlagos k\u00fcl\u00f6nbs\u00e9g:\n                    \u20133,73, 95% CI: \u20134,53; \u20132,92; p&lt;0,0001) \u00e9s a heti nitroglicerin-fogyaszt\u00e1st\n                    (\u20133,23, 95% CI: \u20134,23; \u20132,24; p&lt;0,0001). A h\u00e1rom kezel\u00e9si d\u00f3zis k\u00f6z\u00f6tt az\n                    anginasz\u00e1m cs\u00f6kken\u00e9s\u00e9ben \u00e9s a nitroglicerin-fogyaszt\u00e1sban nem lehetett\n                    k\u00fcl\u00f6nbs\u00e9get kimutatni (p = 0,57, illetve p = 0,48). Tov\u00e1bbi eredm\u00e9nyeink: a k\u00e9t\n                    primer v\u00e1ltoz\u00f3 vizitr\u0151l vizitre cs\u00f6kkent; nagyobb bev\u00e1laszt\u00e1si anginasz\u00e1m a\n                    r\u00f6videbb id\u0151tartam\u00fa tanulm\u00e1nyokban \u00e9s a kisebb adag\u00fa trimetazidint kap\u00f3k k\u00f6z\u00f6tt\n                    fordult el\u0151 gyakrabban, \u00e9s ezek a betegek a t\u00f6bbiekn\u00e9l fiatalabbak voltak. A\n                    r\u00f6videbb id\u0151tartam\u00fa tanulm\u00e1nyokban a kezdeti nitroglicerin-ig\u00e9ny, illetve a\n                    -cs\u00f6kken\u00e9s nagyobb volt a hosszabb id\u0151tartam\u00faakhoz k\u00e9pest.\n                        <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic> A trimetazidin kedvez\u0151 klinikai hat\u00e1s\u00fa\n                    stabil angina pectorisban, az alkalmazott adagt\u00f3l f\u00fcggetlen\u00fcl. \u00daj\n                    meg\u00e1llap\u00edt\u00e1sunk az, hogy a s\u00falyosabb \u00e1llapot\u00fa, fiatalabb betegek kezel\u00e9s\u00e9nek\n                    klinikai haszna a legnagyobb. Orv Hetil. 2020; 161(16): 611\u2013622.<\/jats:p>","DOI":"10.1556\/650.2020.31704","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T14:29:30Z","timestamp":1586874570000},"page":"611-622","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":4,"title":["A k\u00fcl\u00f6nf\u00e9le trimetazidink\u00e9sz\u00edtm\u00e9nyek klinikai hat\u00e1sa stabil angin\u00e1val j\u00e1r\u00f3 kr\u00f3nikus koszor\u00fa\u00e9r-szindr\u00f3m\u00e1ban. Friss\u00edtett m\u00f3dszeres \u00e1ttekint\u00e9s \u00e9s metaanal\u00edzis"],"prefix":"10.1556","volume":"161","author":[{"given":"Viktor L.","family":"Nagy","sequence":"first","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis EgyetemBudapest, Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Herold","sequence":"additional","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Belgy\u00f3gy\u00e1szati Klinika, Semmelweis EgyetemBudapest, Szentkir\u00e1lyi u. 46. 1088"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/16\/article-p611.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/16\/article-p611.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:13Z","timestamp":1633914793000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/16\/article-p611.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":0,"journal-issue":{"issue":"16"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31704","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}