{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:47:34Z","timestamp":1789051654344,"version":"build-2803163510"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"16","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,4]]},"abstract":"Absztrakt: <\/jats:title>\n A \u201edevelopmental origin of health and disease\u201d (DOHaD-) te\u00f3ria 1986-ban jelent\n meg, \u00f6sszehasonl\u00edt\u00f3 epidemiol\u00f3giai vizsg\u00e1latokkal bizony\u00edtva a korai fejl\u0151d\u00e9sben\n megmutatkoz\u00f3 k\u00f3ros elt\u00e9r\u00e9sek (p\u00e9ld\u00e1ul alul- vagy t\u00falt\u00e1pl\u00e1lts\u00e1g, csecsem\u0151kori\n hal\u00e1loz\u00e1s) statisztikai \u00f6sszef\u00fcgg\u00e9s\u00e9t feln\u0151ttkori nem kommunik\u00e1bilis betegs\u00e9gek\n (p\u00e9ld\u00e1ul ischaemi\u00e1s sz\u00edvbetegs\u00e9gek, hypertonia) megjelen\u00e9s\u00e9vel \u2013 \u00e9s az\u00f3ta\n sz\u00e9lesk\u00f6r\u0171en elterjedt. A te\u00f3ria nagyon hasonl\u00f3 a hormon\u00e1lis imprinting\n koncepci\u00f3j\u00e1hoz, mely 6 \u00e9vvel kor\u00e1bban jelent meg, \u00e9s \u00e1llatk\u00eds\u00e9rletek alapj\u00e1n\n bizony\u00edtotta a hormonszer\u0171 molekul\u00e1kkal val\u00f3 perinatalis tal\u00e1lkoz\u00e1s szerep\u00e9t a\n feln\u0151ttkori endokrin \u00e9s endokrin szab\u00e1lyoz\u00e1s alatt \u00e1ll\u00f3 k\u00f3ros jelens\u00e9gek\n fell\u00e9p\u00e9s\u00e9ben. Ami mindk\u00e9t te\u00f3ri\u00e1ban azonos, az a perinatalis expoz\u00edci\u00f3 \u00e9s a\n feln\u0151ttkori jelens\u00e9g (betegs\u00e9g) \u00f6sszef\u00fcgg\u00e9se \u2013 ez az epigenetikai programoz\u00e1s\n zavar\u00e1ra utal. Barker a rendk\u00edv\u00fcl fontos DOHaD-elm\u00e9let megalkot\u00e1sakor m\u00e1r\n ismerte a hormon\u00e1lis imprintinget, amelyet a DOHaD lehets\u00e9ges ok\u00e1nak min\u0151s\u00edtett,\n s ez b\u00e1tor\u00edthatta az elm\u00e9let kidolgoz\u00e1sakor. Barker szerint a DOHaD a nem\n fert\u0151z\u0151 betegs\u00e9gekre vonatkozik, de figyelembe v\u00e9ve, hogy a hib\u00e1s hormon\u00e1lis\n imprinting az immunrendszer feln\u0151ttkori m\u0171k\u00f6d\u00e9s\u00e9t is alapvet\u0151en \u00e9s \u00e9letresz\u00f3l\u00f3an\n befoly\u00e1solja, lehets\u00e9ges a fert\u0151z\u0151 betegs\u00e9gek, s\u0151t az \u00e9lettartam \u00e9rintetts\u00e9ge\n is. A perinatalis id\u0151szakon k\u00edv\u00fcli kritikus peri\u00f3dus m\u00e9g a pubert\u00e1s, amikor\n hib\u00e1s \u00e1tprogramoz\u00f3d\u00e1s fordulhat el\u0151, de bizonyos, folyamatosan differenci\u00e1l\u00f3d\u00f3\n sejtrendszerekben (p\u00e9ld\u00e1ul az immunrendszerben) a hib\u00e1s imprinting feln\u0151ttkorban\n is l\u00e9trej\u00f6het. A k\u00e9t te\u00f3ria nem versenyez egym\u00e1ssal, de elt\u00e9r\u0151 m\u00f3dszereket\n alkalmazva \u00e9s azonos k\u00f6vetkeztet\u00e9sre jutva kieg\u00e9sz\u00edti \u00e9s t\u00e1mogatja egym\u00e1st,\n sz\u00e1mos betegs\u00e9g epigenetikai magyar\u00e1zat\u00e1t (hib\u00e1s \u00e1tprogramoz\u00e1s) adva meg. A\n DOHaD \u00e9s el\u0151zm\u00e9nye, a hormon\u00e1lis imprinting teh\u00e1t nemcsak te\u00f3ri\u00e1k, de\n realit\u00e1sok, melyeket a diagnosztik\u00e1ban \u00e9pp\u00fagy, mint a ter\u00e1pi\u00e1ban aj\u00e1nlatos\n figyelembe venni. V\u00e9giggondolva az emberi alkot\u00f3tev\u00e9kenys\u00e9g tendenci\u00e1it, a DOHaD\n (\u00e9s a hib\u00e1s imprinting) jelent\u0151s\u00e9ge a k\u00f6zeli \u00e9s t\u00e1voli j\u00f6v\u0151ben v\u00e1rhat\u00f3lag\n n\u00f6vekedni fog. Orv Hetil. 2020; 161(16): 603\u2013609.<\/jats:p>","DOI":"10.1556\/650.2020.31713","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T14:29:30Z","timestamp":1586874570000},"page":"603-609","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":6,"title":["DOHaD (Barker-hipot\u00e9zis): egy betegs\u00e9gorient\u00e1lt, korszakalkot\u00f3, brit eredet\u0171 te\u00f3ria, magyar gy\u00f6kerekkel"],"prefix":"10.1556","volume":"161","author":[{"given":"Gy\u00f6rgy","family":"Csaba","sequence":"first","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Genetikai, Sejt- \u00e9s Immunbiol\u00f3giai Int\u00e9zet, Semmelweis EgyetemBudapest"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/16\/article-p603.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/16\/article-p603.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:10Z","timestamp":1633914790000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/16\/article-p603.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":0,"journal-issue":{"issue":"16"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31713","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}