{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:35:24Z","timestamp":1723134924441},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"21","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Absztrakt: <\/jats:title>\n Bevezet\u00e9s:<\/jats:bold><\/jats:italic> A biszfoszfon\u00e1tok \u00e1ltal okozott\n \u00e1llcsontnekr\u00f3zis (BRONJ) az \u00e9letmin\u0151s\u00e9get jelent\u0151sen befoly\u00e1sol\u00f3 megbeteged\u00e9s,\n mely mind \u00e1ltal\u00e1nos, mind seb\u00e9szeti vonatkoz\u00e1saiban indokolja a korai diagn\u00f3zis\n fel\u00e1ll\u00edt\u00e1s\u00e1t, illetve a kialakul\u00e1s kock\u00e1zat\u00e1nak felm\u00e9r\u00e9s\u00e9t.\n C\u00e9lkit\u0171z\u00e9s:<\/jats:bold><\/jats:italic> A BRONJ progn\u00f3zis\u00e1nak becsl\u00e9se\n nem megoldott, sz\u00e1mos radiol\u00f3giai lehet\u0151s\u00e9g k\u00f6z\u00fcl a legkedvez\u0151bbnek a\n fog\u00e1szatban haszn\u00e1latos k\u00e9palkot\u00f3 elj\u00e1r\u00e1sok t\u0171nnek, melyek k\u00f6z\u00fcl a\n leg\u00edg\u00e9retesebb lehet a \u2019cone-beam computed tomography\u2019 (CBCT). Az oralisan\n alkalmazott biszfoszfon\u00e1tter\u00e1pia k\u00f6vetkezt\u00e9ben kialakul\u00f3 BRONJ kock\u00e1zatbecsl\u00e9s\u00e9t\n nem hangs\u00falyozz\u00e1k a vizsg\u00e1latok, a nagyobb kock\u00e1zatot jelent\u0151 intrav\u00e9n\u00e1s\n alkalmaz\u00e1sra f\u00f3kusz\u00e1lnak. M\u00f3dszer:<\/jats:bold><\/jats:italic> M\u00e9r\u00e9seinket \u2013\n az eddig publik\u00e1lt vizsg\u00e1latokkal ellent\u00e9tben \u2013 preoperat\u00edv CBCT-felv\u00e9teleken\n v\u00e9gezt\u00fck, ez\u00e1ltal a kock\u00e1zatbecsl\u00e9s lehet\u0151s\u00e9g\u00e9t k\u00f6zvetlen\u00fcl vizsg\u00e1ltuk.\n Vizsg\u00e1latainkat CBCT-felv\u00e9telek \u00e9rt\u00e9kel\u00e9s\u00e9vel v\u00e9gezt\u00fck; reprezentat\u00edv\n ter\u00fcletk\u00e9nt a foramen mentale k\u00f6z\u00e9pvonal\u00e1ban elhelyezked\u0151 front\u00e1lis metszeteket\n v\u00e1lasztottuk ki, \u00e9s t\u00f6bb ponton m\u00e9rt\u00fcnk denzit\u00e1st, a corticalis csont\u00e1llom\u00e1ny\n vastags\u00e1g\u00e1t, valamint a foramen mentale \u00e1tm\u00e9r\u0151j\u00e9t is megm\u00e9rt\u00fck. Az els\u0151\n vizsg\u00e1lati csoportban olyan osteoporosisos betegeket vizsg\u00e1ltunk, akikn\u00e9l oralis\n biszfoszfon\u00e1tter\u00e1pi\u00e1t k\u00f6vet\u0151en alakult ki BRONJ. A m\u00e1sodik csoportban olyan\n betegeket n\u00e9zt\u00fcnk, akik osteoporosis miatt oralis biszfoszfon\u00e1tter\u00e1pi\u00e1ban\n r\u00e9szes\u00fcltek, \u00e9s a sz\u00e1jseb\u00e9szeti beavatkoz\u00e1st k\u00f6vet\u0151en nem alakult ki BRONJ. A\n kontrollcsoportban olyan betegek voltak, akik nem kaptak a BRONJ etiol\u00f3gi\u00e1j\u00e1ban\n szerepl\u0151 gy\u00f3gyszert. Eredm\u00e9nyek:<\/jats:bold><\/jats:italic> Eredm\u00e9nyeink\n alapj\u00e1n elmondhat\u00f3, hogy a preoperat\u00edv CBCT-felv\u00e9teleket \u00e9rt\u00e9kelve nem\n tapasztalhat\u00f3 jelent\u0151s k\u00fcl\u00f6nbs\u00e9g a BRONJ-elv\u00e1ltoz\u00e1st\u00f3l szenved\u0151k \u00e9s az\n eg\u00e9szs\u00e9gesek csontdenzit\u00e1si \u00e9rt\u00e9kei k\u00f6z\u00f6tt.\n K\u00f6vetkeztet\u00e9s:<\/jats:bold><\/jats:italic> Ezek alapj\u00e1n kijelenthet\u0151, hogy\n a sug\u00e1rterhel\u00e9ssel j\u00e1r\u00f3 CBCT-felv\u00e9tel az osteoporosis miatt oralis\n biszfoszfon\u00e1tot szed\u0151k eset\u00e9ben a BRONJ prognosztikai becsl\u00e9s\u00e9re nem\n alkalmazhat\u00f3. Mindez fontos ahhoz, hogy a progn\u00f3zisbecsl\u00e9shez a p\u00e1cienst \u00e9r\u0151\n sug\u00e1rd\u00f3zist ne emelj\u00fck sz\u00fcks\u00e9gtelen\u00fcl az ALARA (as low as reasonably\n achievable)-elv \u00e9rtelm\u00e9ben. Orv Hetil. 2020; 161(21): 867\u2013872.<\/jats:p>","DOI":"10.1556\/650.2020.31732","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T09:21:25Z","timestamp":1589880085000},"page":"867-872","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":4,"title":["A biszfoszfon\u00e1tkezel\u00e9s \u00e1llcsontnekr\u00f3zist el\u0151id\u00e9z\u0151 kock\u00e1zat\u00e1nak meg\u00edt\u00e9l\u00e9se CBCT-felv\u00e9telek alapj\u00e1n"],"prefix":"10.1556","volume":"161","author":[{"given":"Ferenc","family":"Kopp\u00e1ny","sequence":"first","affiliation":[{"name":"1 Fogorvostudom\u00e1nyi Kar, Arc-, \u00c1llcsont-, Sz\u00e1jseb\u00e9szeti \u00e9s Fog\u00e1szati Klinika, Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1rp\u00e1d","family":"Jo\u00f3b-Fancsaly","sequence":"additional","affiliation":[{"name":"1 Fogorvostudom\u00e1nyi Kar, Arc-, \u00c1llcsont-, Sz\u00e1jseb\u00e9szeti \u00e9s Fog\u00e1szati Klinika, Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"1 Fogorvostudom\u00e1nyi Kar, Arc-, \u00c1llcsont-, Sz\u00e1jseb\u00e9szeti \u00e9s Fog\u00e1szati Klinika, Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Alexandra","family":"Belik","sequence":"additional","affiliation":[{"name":"2 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Orvosi Vegytani, Molekul\u00e1ris Biol\u00f3giai \u00e9s Patobiok\u00e9miai Int\u00e9zet, Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mih\u00e1ly","family":"Vaszilk\u00f3","sequence":"additional","affiliation":[{"name":"1 Fogorvostudom\u00e1nyi Kar, Arc-, \u00c1llcsont-, Sz\u00e1jseb\u00e9szeti \u00e9s Fog\u00e1szati Klinika, Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edv\u00e1rd M\u00e1rton","family":"Varmuzsa","sequence":"additional","affiliation":[{"name":"3 Fogorvostudom\u00e1nyi Kar, Semmelweis Egyetem Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriszti\u00e1n Benedek","family":"Csom\u00f3","sequence":"additional","affiliation":[{"name":"1 Fogorvostudom\u00e1nyi Kar, Arc-, \u00c1llcsont-, Sz\u00e1jseb\u00e9szeti \u00e9s Fog\u00e1szati Klinika, Semmelweis Egyetem Budapest"},{"name":"4 Fogorvostudom\u00e1nyi Kar, Konzerv\u00e1l\u00f3 Fog\u00e1szati Klinika, Semmelweis Egyetem Budapest, M\u00e1ria u. 52., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/21\/article-p867.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/21\/article-p867.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:58Z","timestamp":1633914838000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/21\/article-p867.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":0,"journal-issue":{"issue":"21"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31732","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5]]}}}