{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T19:05:34Z","timestamp":1661799934387},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"35","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n                <jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A zs\u00edrm\u00e1j kialakulhat betegs\u00e9gek, m\u0171t\u00e9tek,\n                    gy\u00f3gyszerek, \u00e9hez\u00e9s vagy t\u00falzott m\u00e9rt\u00e9k\u0171 alkoholfogyaszt\u00e1s k\u00f6vetkezt\u00e9ben, de a\n                    helytelen t\u00e1pl\u00e1lkoz\u00e1st, a zs\u00edrb\u0151 \u00e9s rostszeg\u00e9ny \u00e9tkez\u00e9st tartj\u00e1k az els\u0151dleges\n                    oknak. A nem alkoholos zs\u00edrm\u00e1jbetegs\u00e9g a lakoss\u00e1g 20\u201330%-\u00e1t \u00e9rintheti. A\n                    t\u00e1pl\u00e1lkoz\u00e1si eredet\u0171 zs\u00edrm\u00e1jat korai st\u00e1diumban \u00e1ltal\u00e1ban sz\u00f6v\u0151dm\u00e9nymentes\n                    m\u00e1jk\u00e1rosod\u00e1snak \u00edrj\u00e1k le. <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Kutat\u00e1saink c\u00e9lja a\n                    zs\u00edrd\u00fas t\u00e1pl\u00e1lkoz\u00e1s b\u00e9l\u2013m\u00e1j tengelyre gyakorolt hat\u00e1s\u00e1nak a felt\u00e9rk\u00e9pez\u00e9se volt.\n                        <jats:italic>M\u00f3dszerek:<\/jats:italic> Rutinlaborat\u00f3riumi, analitikai \u00e9s sz\u00f6vettani\n                    m\u00f3dszerekkel patk\u00e1nyokban vizsg\u00e1ltuk a b\u00e9l \u00e9s a m\u00e1j redoxparam\u00e9tereit, valamint\n                    a m\u00e1j zs\u00edrsav\u00f6sszet\u00e9tel\u00e9t \u00e9s elemtartalm\u00e1t. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> A m\u00e1j\n                    elzs\u00edrosod\u00e1sa sor\u00e1n a v\u00e9rsz\u00e9rumban m\u00e9rhet\u0151 m\u00e1jenzim- \u00e9s metabolit\u00e9rt\u00e9kek\n                    elt\u00e9r\u00e9sei mellett a redox-homeoszt\u00e1zis mutat\u00f3iban is szignifik\u00e1ns v\u00e1ltoz\u00e1sok\n                    igazol\u00f3dtak. V\u00e1ltoz\u00e1s volt kimutathat\u00f3 a m\u00e1jban, a v\u00e9rben \u00e9s a belekben. A m\u00e1j\n                    elzs\u00edrosod\u00e1s\u00e1nak folyamata egy\u00fctt j\u00e1r a transzmetil\u00e1l\u00f3 k\u00e9pess\u00e9g cs\u00f6kken\u00e9s\u00e9vel.\n                    Megv\u00e1ltozott a zs\u00edrsav\u00f6sszet\u00e9tel \u00e9s a f\u00e9mion-homeoszt\u00e1zis is a m\u00e1jban.\n                    Sz\u00f6vettani vizsg\u00e1latokn\u00e1l a m\u00e1jlobulusok centr\u00e1lis r\u00e9sz\u00e9n a hepatocyt\u00e1k\n                    megduzzadtak, benn\u00fck zs\u00edrcseppek l\u00e1that\u00f3k, piknotikus sejtmagok alakultak ki,\n                    ami a zs\u00edros elfajul\u00e1sra jellemz\u0151. A v\u00e9kony- \u00e9s vastagb\u00e9l enterocyt\u00e1i s\u00e9r\u00fcltek,\n                    helyenk\u00e9nt lel\u00f6k\u0151dtek a felsz\u00ednr\u0151l, \u00e9s gyullad\u00e1sos reakci\u00f3k figyelhet\u0151k meg a\n                    ny\u00e1lkah\u00e1rty\u00e1ban. <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Eredm\u00e9nyeink alapj\u00e1n\n                    lesz\u00f6gezhet\u0151, hogy a zs\u00edrd\u00fas di\u00e9ta okozta steatosis m\u00e1r korai st\u00e1diumban sem\n                    tekinthet\u0151 egyszer\u0171en reverzibilis v\u00e1ltoz\u00e1snak, mert a v\u00e1ltoz\u00e1sok kedvez\u0151tlen\u00fcl\n                    befoly\u00e1solj\u00e1k az eg\u00e9sz szervezet redox-homeoszt\u00e1zis\u00e1t, \u00e9s egyben alapj\u00e1t\n                    k\u00e9pezhetik s\u00falyos sz\u00edv- \u00e9s metabolikus betegs\u00e9geknek, valamint siettethetik a\n                    gastrointestinalis tumorok kialakul\u00e1s\u00e1t. Orv Hetil. 2020; 161(35):\n                    1456\u20131465.<\/jats:p>","DOI":"10.1556\/650.2020.31786","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T01:01:27Z","timestamp":1599008487000},"page":"1456-1465","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["A zs\u00edrd\u00fas \u00e9trend induk\u00e1lta steatosis \u00e9s a b\u00e9l\u2013m\u00e1j tengely v\u00e1ltoz\u00e1sai"],"prefix":"10.1556","volume":"161","author":[{"given":"Anna","family":"Bl\u00e1zovics","sequence":"first","affiliation":[{"name":"1 Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar, Farmakogn\u00f3ziai Int\u00e9zet, Semmelweis Egyetem, Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Sipos","sequence":"additional","affiliation":[{"name":"2 Orvostudom\u00e1nyi Kar, Anat\u00f3miai, Sz\u00f6vet- \u00e9s Fejl\u0151d\u00e9stani Int\u00e9zet, Semmelweis Egyetem, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibolya","family":"Kocsis","sequence":"additional","affiliation":[{"name":"3 Orvostudom\u00e1nyi Kar, Laborat\u00f3riumi Medicina Int\u00e9zet, Semmelweis Egyetem, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedvig","family":"F\u00e9bel","sequence":"additional","affiliation":[{"name":"4 NAIK \u00c1llatteny\u00e9szt\u00e9si, Takarm\u00e1nyoz\u00e1si \u00e9s H\u00fasipari Kutat\u00f3int\u00e9zet, Herceghalom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9nes","family":"Kleiner","sequence":"additional","affiliation":[{"name":"1 Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar, Farmakogn\u00f3ziai Int\u00e9zet, Semmelweis Egyetem, Budapest, \u00dcll\u0151i \u00fat 26., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Szentmih\u00e1lyi","sequence":"additional","affiliation":[{"name":"1 Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar, Farmakogn\u00f3ziai Int\u00e9zet, Semmelweis Egyetem, Budapest, \u00dcll\u0151i \u00fat 26., 1085"},{"name":"5 Anyag- \u00e9s K\u00f6rnyezetk\u00e9miai Int\u00e9zet, Term\u00e9szettudom\u00e1nyi Kutat\u00f3k\u00f6zpont, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Feh\u00e9r","sequence":"additional","affiliation":[{"name":"2 Orvostudom\u00e1nyi Kar, Anat\u00f3miai, Sz\u00f6vet- \u00e9s Fejl\u0151d\u00e9stani Int\u00e9zet, Semmelweis Egyetem, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/35\/article-p1456.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/35\/article-p1456.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:10Z","timestamp":1633914790000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/35\/article-p1456.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":0,"journal-issue":{"issue":"35"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31786","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}