{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:26:33Z","timestamp":1785529593944,"version":"3.56.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"35","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n                <jats:p>Az enteralis idegrendszerben termelt neuropeptidek szerepet j\u00e1tszanak az\n                    immunsejtek m\u0171k\u00f6d\u00e9s\u00e9ben, r\u00e9szt vesznek a gyullad\u00e1s fokoz\u00e1s\u00e1ban \u00e9s annak\n                    cs\u00f6kkent\u00e9s\u00e9ben. \u00d6sszefoglal\u00f3 munk\u00e1nkban azt elemezt\u00fck, hogy a gyullad\u00e1s milyen\n                    hat\u00e1st fejt ki az idegelemek \u00e9s immunsejtek neuropeptid-tartalm\u00e1ra. Gyullad\u00e1sos\n                    mint\u00e1kat (human gastritis, \u00e1llatk\u00eds\u00e9rletes induk\u00e1lt colitis, sztreptozotocinnal\n                    induk\u00e1lt diabetes mellitus) \u00e9s kontrollprepar\u00e1tumokat hasonl\u00edtottunk \u00f6ssze. A\n                    neuropeptid-tartalm\u00fa idegrostok \u00e9s immunsejtek mennyis\u00e9g\u00e9t vizsg\u00e1ltuk\n                    (immunhisztok\u00e9mia, konfok\u00e1lis l\u00e9zermikroszk\u00f3pia, elektronmikroszk\u00f3pia),\n                    esetleges k\u00f6zeli kapcsolatokat kerest\u00fcnk. Gyullad\u00e1sos folyamatokban (gastritis,\n                    k\u00eds\u00e9rletes colitis, diabetes mellitus) a substance P, neuropeptid Y \u00e9s vasoactiv\n                    intestinalis peptid pozit\u00edv idegrostok mennyis\u00e9ge szignifik\u00e1nsan megemelkedett,\n                    s ezzel p\u00e1rhuzamosan a ny\u00e1lkah\u00e1rty\u00e1ban l\u00e9v\u0151 immunkompetens sejtek (lymphocyt\u00e1k,\n                    plazmasejtek, h\u00edz\u00f3sejtek) sz\u00e1ma szint\u00e9n jelent\u0151s m\u00e9rt\u00e9kben megn\u0151tt (p&lt;0,001).\n                    Gyullad\u00e1s hat\u00e1s\u00e1ra az immunsejtek aktiv\u00e1l\u00f3dtak \u00e9s pozit\u00edvan jel\u00f6l\u0151dtek substance\n                    P, neuropeptid Y \u00e9s vasoactiv intestinalis peptid elleni antitestekkel.\n                    Kontrollanyagban sohasem siker\u00fclt nagyon k\u00f6zeli idegrost-immunsejt k\u00f6z\u00f6tti\n                    morfol\u00f3giai kapcsolatot kimutatni, viszont gyullad\u00e1s hat\u00e1s\u00e1ra sz\u00e1mos immunsejt\n                    mellett tal\u00e1lhat\u00f3 idegrostk\u00f6teg, ahol az idegrostok egy r\u00e9sze immunpozitivit\u00e1st\n                    mutat substance P-re, neuropeptid Y-ra \u00e9s vasoactiv intestinalis peptidre.\n                    Konfok\u00e1lis l\u00e9zermikroszk\u00f3ppal kett\u0151s jel\u00f6l\u00e9ssel bizony\u00edtottuk, hogy\n                    tumornekr\u00f3zisfaktor-alfa- \u00e9s nukle\u00e1risfaktor-kappa-B-pozit\u00edv immunsejtek egy\n                    r\u00e9sz\u00e9ben a substance P kolokaliz\u00e1ci\u00f3ban fordul el\u0151. A tumornekr\u00f3zisfaktor-alfa\n                    \u00e9s nukle\u00e1risfaktor-kappa-B-pozit\u00edv immunsejtek mennyis\u00e9g\u00e9nek emelked\u00e9se\n                    korrel\u00e1lt (p\u00e1rhuzamosan emelkedett) a substance P-immunreakt\u00edv idegrostok\n                    mennyis\u00e9g\u00e9nek n\u00f6veked\u00e9s\u00e9vel human gastritisben. Eredm\u00e9nyeink al\u00e1t\u00e1masztj\u00e1k, hogy\n                    substance P-antagonist\u00e1k vagy neuropeptid Y \u00e9s vasoactiv intestinalis peptid\n                    alkalmaz\u00e1sa az ut\u00f3bbi \u00e9vtizedben \u00faj ter\u00e1pi\u00e1s lehet\u0151s\u00e9g lehet a kr\u00f3nikus\n                    gyullad\u00e1sok kezel\u00e9s\u00e9re. Orv Hetil. 2020; 161(35): 1436\u20131440.<\/jats:p>","DOI":"10.1556\/650.2020.31795","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T01:01:27Z","timestamp":1599008487000},"page":"1436-1440","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Neuroimmun-modul\u00e1ci\u00f3 az em\u00e9szt\u0151csatorna ny\u00e1lkah\u00e1rty\u00e1j\u00e1ban"],"prefix":"10.1556","volume":"161","author":[{"given":"Erzs\u00e9bet","family":"Feh\u00e9r","sequence":"first","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Anat\u00f3miai, Sz\u00f6vet- \u00e9s Fejl\u0151d\u00e9stani Int\u00e9zet, Semmelweis Egyetem, Budapest, T\u0171zolt\u00f3 u. 58., 1094"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1roly","family":"Altdorfer","sequence":"additional","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Anat\u00f3miai, Sz\u00f6vet- \u00e9s Fejl\u0151d\u00e9stani Int\u00e9zet, Semmelweis Egyetem, Budapest, T\u0171zolt\u00f3 u. 58., 1094"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/35\/article-p1436.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/35\/article-p1436.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:14Z","timestamp":1633914794000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/35\/article-p1436.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":0,"journal-issue":{"issue":"35"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31795","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}