{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T17:09:58Z","timestamp":1698340198100},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"31","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n                <jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> A system\u00e1s lupus erythematosus (SLE) legs\u00falyosabb\n                    manifeszt\u00e1ci\u00f3ja a lupus nephritis, melynek kialakul\u00e1sa \u00e9s az immunszuppressz\u00edv\n                    kezel\u00e9s eredm\u00e9nyess\u00e9ge alapvet\u0151en meghat\u00e1rozza a betegek \u00e9letkil\u00e1t\u00e1s\u00e1t \u00e9s\n                    \u00e9letmin\u0151s\u00e9g\u00e9t. <jats:italic>C\u00e9lkit\u0171z\u00e9s<\/jats:italic>: Retrospekt\u00edv obszerv\u00e1ci\u00f3s\n                    vizsg\u00e1latunk c\u00e9lja a Szent Margit K\u00f3rh\u00e1z Immunonephrologiai Ambulanci\u00e1j\u00e1n lupus\n                    nephritis miatt tart\u00f3san gondozott betegeink hossz\u00fa t\u00e1v\u00fa kezel\u00e9s\u00e9nek \u00e9rt\u00e9kel\u00e9se\n                    volt. <jats:italic>Eredm\u00e9nyek:<\/jats:italic> Vizsg\u00e1latunkban az 1997. december 1. \u00e9s 2019.\n                    \u00e1prilis 30. k\u00f6z\u00f6tt gondozott lupus nephritises betegek adatait elemezt\u00fck. A 73\n                    betegn\u00e9l (akik 33,7 \u00b1 15 \u00e9vesek, 82% n\u0151, 18% f\u00e9rfi, a megfigyel\u00e9si id\u0151\n                    k\u00f6z\u00e9p\u00e9rt\u00e9ke 119 h\u00f3 [sz\u00e9ls\u0151\u00e9rt\u00e9kek 3\u2013264]) a lupus nephritis diagnosztiz\u00e1l\u00e1sakor\n                    a betegek nagy r\u00e9sz\u00e9ben jelent\u0151sen besz\u0171k\u00fclt vesefunkci\u00f3t \u00e9szlelt\u00fcnk, az eGFR 68\n                    [7\u2013120] ml\/min, a proteinuria 2800 [23\u201316812] mg\/nap volt; 10 f\u0151 akutan\n                    hemodial\u00edzis-kezel\u00e9sre szorult. A 68 f\u0151n\u00e9l elv\u00e9gzett vesebiopszia eredm\u00e9nye 55\n                    f\u0151n\u00e9l proliferat\u00edv, 6 betegn\u00e9l membranosus lupus nephritist igazolt. Kombin\u00e1lt\n                    immunszuppresszi\u00f3 alkalmaz\u00e1s\u00e1val 50 esetben komplett, 21 betegn\u00e9l r\u00e9szleges\n                    remisszi\u00f3t siker\u00fclt el\u00e9rni; 28 f\u0151n\u00e9l egy vagy t\u00f6bb alkalommal relapsus\n                    jelentkezett. Ketten m\u00e1r a gondoz\u00e1sba ker\u00fcl\u00e9s\u00fckkor kr\u00f3nikus dial\u00edzisre\n                    szorultak, emellett 3 betegn\u00e9l a vesefunkci\u00f3 hossz\u00fa t\u00e1von v\u00e9gst\u00e1dium\u00fa\n                    veseel\u00e9gtelens\u00e9gig progredi\u00e1lt. A t\u00f6bbiek vesem\u0171k\u00f6d\u00e9se stabiliz\u00e1l\u00f3dott, k\u00f6zel\n                    norm\u00e1liss\u00e1 v\u00e1ltak a SLE aktivit\u00e1s\u00e1t jelz\u0151 SLEDAI-pontsz\u00e1m, a komplement- \u00e9s\n                    immunleletek. <jats:italic>K\u00f6vetkeztet\u00e9sek:<\/jats:italic> A lupus nephritis kombin\u00e1lt\n                    indukci\u00f3s \u00e9s elh\u00faz\u00f3d\u00f3an alkalmazott fenntart\u00f3 immunszuppresszi\u00f3val megfelel\u0151en\n                    kezelhet\u0151, a betegs\u00e9g progresszi\u00f3j\u00e1nak megakad\u00e1lyoz\u00e1s\u00e1hoz azonban tart\u00f3s\n                    gondoz\u00e1s sz\u00fcks\u00e9ges, nephrologus-immunol\u00f3gus egy\u00fcttm\u0171k\u00f6d\u00e9s\u00e9vel. Az alapbetegs\u00e9g\n                    t\u00f6bbszervi manifeszt\u00e1ci\u00f3j\u00e1nak \u00e9s az immunszuppresszi\u00f3 potenci\u00e1lis\n                    sz\u00f6v\u0151dm\u00e9nyeinek kiv\u00e9d\u00e9s\u00e9re az ell\u00e1t\u00f3 teamnek mag\u00e1ban kell foglalnia mindazon\n                    szakembereket, akik hozz\u00e1j\u00e1rulhatnak a komplex ell\u00e1t\u00e1st ig\u00e9nyl\u0151 betegek\n                    \u00e1llapot\u00e1nak javul\u00e1s\u00e1hoz. C\u00e9lszer\u0171, hogy a lupus nephritises beteg gondoz\u00e1s\u00e1t \u00e9s\n                    az egy\u00fcttm\u0171k\u00f6d\u0151 team vezet\u00e9s\u00e9t nephrologus ir\u00e1ny\u00edtsa. Orv Hetil. 2020; 161(31):\n                    1293\u20131301.<\/jats:p>","DOI":"10.1556\/650.2020.31801","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T01:02:26Z","timestamp":1595984546000},"page":"1293-1301","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Tart\u00f3s immunonephrol\u00f3giai gondoz\u00e1sban r\u00e9szes\u00fclt lupus nephritises betegeink hossz\u00fa t\u00e1v\u00fa kezel\u00e9si eredm\u00e9nyei"],"prefix":"10.1556","volume":"161","author":[{"given":"K\u00e1lm\u00e1n","family":"Polner","sequence":"first","affiliation":[{"name":"1 Taraba Istv\u00e1n M\u0171vese \u00c1llom\u00e1s, Szent Margit K\u00f3rh\u00e1z, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Ar\u00e1nyi","sequence":"additional","affiliation":[{"name":"2 II. Belgy\u00f3gy\u00e1szat, Nephrol\u00f3gia \u00e9s Gasztroenterol\u00f3gia Oszt\u00e1ly, Szent Margit K\u00f3rh\u00e1z, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Braunitzer","sequence":"additional","affiliation":[{"name":"2 II. Belgy\u00f3gy\u00e1szat, Nephrol\u00f3gia \u00e9s Gasztroenterol\u00f3gia Oszt\u00e1ly, Szent Margit K\u00f3rh\u00e1z, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Kasz\u00e1s","sequence":"additional","affiliation":[{"name":"3 Patol\u00f3gia Oszt\u00e1ly, Szent Margit K\u00f3rh\u00e1z, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Haris","sequence":"additional","affiliation":[{"name":"4 I. Belgy\u00f3gy\u00e1szat, Nephrol\u00f3gia \u00e9s Gasztroenterol\u00f3gia Oszt\u00e1ly, P\u00e9terfy K\u00f3rh\u00e1z-Rendel\u0151int\u00e9zet \u00e9s Manninger Jen\u0151 Orsz\u00e1gos Traumatol\u00f3giai Int\u00e9zet, Budapest, P\u00e9terfy S. u. 8\u201320., 1076"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/31\/article-p1293.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/31\/article-p1293.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:14:07Z","timestamp":1633914847000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/31\/article-p1293.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":0,"journal-issue":{"issue":"31"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31801","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}