{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:42:32Z","timestamp":1649205752788},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"38","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n                <jats:p>A nemszteroid gyullad\u00e1scs\u00f6kkent\u0151k (NSAID-ok) lok\u00e1lis \u00e9s sziszt\u00e9m\u00e1s form\u00e1ban\n                    t\u00f6rt\u00e9n\u0151 alkalmaz\u00e1sa egyre elterjedtebb\u00e9 v\u00e1lt, az ezzel kapcsolatos adverz\n                    reakci\u00f3k gyakoriak. A szerz\u0151k egy 49 \u00e9ves f\u00e9rfi beteg eset\u00e9t ismertetik, aki\n                    l\u00e1bsz\u00e1rak f\u00e1jdalma miatt etofenam\u00e1ttartalm\u00fa lok\u00e1lis k\u00e9sz\u00edtm\u00e9nyt alkalmazott,\n                    majd az alkalmaz\u00e1s hely\u00e9n, UV-expoz\u00edci\u00f3t k\u00f6vet\u0151en, haemorrhagi\u00e1s, at\u00edpusos,\n                    kontaktdermatitisnek megfelel\u0151 b\u0151rt\u00fcnetek jelentek meg. T\u00fcneteinek rapid\n                    terjed\u00e9se miatt s\u00fcrg\u0151ss\u00e9gi fekv\u0151beteg-ell\u00e1t\u00e1sra szorult. Fizik\u00e1lis vizsg\u00e1lata\n                    sor\u00e1n az etofenam\u00e1texpoz\u00edci\u00f3 hely\u00e9n, mindk\u00e9t l\u00e1bsz\u00e1ron, valamint azon t\u00falmen\u0151en\n                    a karokon, valamint a t\u00f6rzs\u00f6n \u00e9s az arcon bev\u00e9rzett, konflu\u00e1l\u00f3, erythem\u00e1s\n                    seropapul\u00e1kat \u00e9s macul\u00e1kat l\u00e1ttunk, melyek mellett testszerte \u00e9s a buccalis\n                    ny\u00e1lkah\u00e1rty\u00e1n petechi\u00e1k voltak megfigyelhet\u0151k. A nagy kiterjed\u00e9s\u0171 \u00e9s aspecifikus\n                    b\u0151rt\u00fcnetek, a fizik\u00e1lis vizsg\u00e1lattal \u00e9szlelt splenomegalia, valamint a\n                    perif\u00e9ri\u00e1s v\u00e9rk\u00e9pelt\u00e9r\u00e9s miatt ind\u00edtott onkohematol\u00f3giai kivizsg\u00e1l\u00e1s sor\u00e1n hajas\n                    sejtes leukaemia diagn\u00f3zisa igazol\u00f3dott. Epicutan tesztel\u00e9s (ET) sor\u00e1n az\n                    etofenam\u00e1ttartalm\u00fa g\u00e9lre adott, er\u0151sen pozit\u00edv reakci\u00f3 mellett fak\u00e1tr\u00e1ny-,\n                    propil\u00e9n-glikol-, propolisz-, \u2019fragrance mix I\u2019, metilizotiazolinon-, benzoesav-\n                    \u00e9s perubalzsam-poliszenzibiliz\u00e1ci\u00f3 volt verifik\u00e1lhat\u00f3. Az etofenam\u00e1t\n                    hat\u00f3anyaggal elv\u00e9gzett lymphocytatranszform\u00e1ci\u00f3s teszt (LTT) \u00e9s\n                    CD69-expresszi\u00f3-vizsg\u00e1lat negat\u00edv eredm\u00e9nyt adott. Orv Hetil. 2020; 161(38):\n                    1646\u20131651.<\/jats:p>","DOI":"10.1556\/650.2020.31831","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T01:02:02Z","timestamp":1600218122000},"page":"1646-1651","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["At\u00edpusos haemorrhagi\u00e1s b\u0151rt\u00fcnetek h\u00e1tter\u00e9ben igazolt hajas sejtes leukaemia poliszenzibiliz\u00e1lt betegen"],"prefix":"10.1556","volume":"161","author":[{"given":"Melinda","family":"F\u00e1bi\u00e1n","sequence":"first","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Semmelweis Egyetem, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgyi","family":"P\u00f3nyai","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Semmelweis Egyetem, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"Szombath","sequence":"additional","affiliation":[{"name":"2 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3giai Klinika, Semmelweis Egyetem, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Nagy","sequence":"additional","affiliation":[{"name":"3 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Laborat\u00f3riumi Medicina Int\u00e9zet, Semmelweis Egyetem, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Koml\u00f3si","sequence":"additional","affiliation":[{"name":"3 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Laborat\u00f3riumi Medicina Int\u00e9zet, Semmelweis Egyetem, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Szigeti","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Semmelweis Egyetem, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kende","family":"L\u0151rincz","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Semmelweis Egyetem, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadett","family":"Hidv\u00e9gi","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Semmelweis Egyetem, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Medvecz","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Semmelweis Egyetem, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/38\/article-p1646.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/38\/article-p1646.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:14:17Z","timestamp":1633914857000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/38\/article-p1646.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":0,"journal-issue":{"issue":"38"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31831","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}