{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T06:33:14Z","timestamp":1722321194508},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"35","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n                <jats:p>Az autophagi\u00e1nak fontos szerepe van a sejtm\u0171k\u00f6d\u00e9s egyens\u00faly\u00e1nak fenntart\u00e1s\u00e1ban.\n                    Aktivit\u00e1s\u00e1nak cs\u00f6kken\u00e9se kulcsfontoss\u00e1g\u00fa k\u00fcl\u00f6nb\u00f6z\u0151 m\u00e1jbetegs\u00e9gek kialakul\u00e1s\u00e1ban\n                    \u00e9s progresszi\u00f3j\u00e1ban. A cs\u00f6kkent autophagia hozz\u00e1j\u00e1rul a sejtek elzs\u00edrosod\u00e1s\u00e1hoz,\n                    az endoplasmaticus reticulum stressz fokoz\u00e1s\u00e1hoz \u00e9s a m\u00e1jbetegs\u00e9g\n                    el\u0151rehalad\u00e1s\u00e1hoz nem alkoholos eredet\u0171 zs\u00edrm\u00e1jban. A kr\u00f3nikus alkoholfogyaszt\u00e1s\n                    g\u00e1tolja az autophagi\u00e1t. Alfa-1-antitripszin-hi\u00e1nyban az autophagia hozz\u00e1j\u00e1rul az\n                    endoplasmaticus reticulumban lerak\u00f3dott k\u00f3ros feh\u00e9rj\u00e9k lebont\u00e1s\u00e1hoz. A hepatitis\n                    C- \u00e9s B-v\u00edrusok felhaszn\u00e1lj\u00e1k az autophagi\u00e1t saj\u00e1t replik\u00e1ci\u00f3jukhoz. A hepatitis\n                    C-v\u00edrus nem struktur\u00e1lis 5A \u00e9s 5B feh\u00e9rj\u00e9i serkentik az autophagosoma-k\u00e9pz\u0151d\u00e9st.\n                    A mikro-RNS-ek a g\u00e9nexpresszi\u00f3 m\u00f3dos\u00edt\u00e1s\u00e1val szerepet j\u00e1tszanak sz\u00e1mos\n                    fiziol\u00f3gi\u00e1s \u00e9s patol\u00f3gi\u00e1s folyamatban, \u00edgy az autophagia szab\u00e1lyoz\u00e1s\u00e1ban is. A\n                    mikro-RNS-122 a HCV-replik\u00e1ci\u00f3ban j\u00e1tszik szerepet. HBV-fert\u0151z\u00e9sben a\n                    mikro-RNS-ek befoly\u00e1solj\u00e1k a sejthal\u00e1lt, a DNS-k\u00e1rosod\u00e1st, a v\u00edrus\n                    rekombin\u00e1ci\u00f3j\u00e1t \u00e9s a sejten bel\u00fcli jel\u00e1tvitelt. Nem alkoholos eredet\u0171 zs\u00edrm\u00e1jban\n                    a mikro-RNS-122 a zs\u00edr- \u00e9s sz\u00e9nhidr\u00e1t-anyagcser\u00e9n kereszt\u00fcl fejti ki hat\u00e1s\u00e1t.\n                    Alkoholos m\u00e1jbetegs\u00e9gekben a mikro-RNS-ek az oxidat\u00edv stressz \u00e9s a\n                    szabadgy\u00f6k-k\u00e9pz\u0151d\u00e9s \u00fatj\u00e1n befoly\u00e1solj\u00e1k a betegs\u00e9get. A mikro-RNS-ek hat\u00e1ssal\n                    vannak az autophagi\u00e1ra, \u00e9s az autophagia is befoly\u00e1solja a mikro-RNS-ek\n                    expresszi\u00f3j\u00e1t. K\u00f6lcs\u00f6nhat\u00e1suk megismer\u00e9se k\u00f6zelebb visz a m\u00e1jbetegs\u00e9gek\n                    kialakul\u00e1s\u00e1nak meg\u00e9rt\u00e9s\u00e9hez. Orv Hetil. 2020; 161(35): 1449\u20131455.<\/jats:p>","DOI":"10.1556\/650.2020.31834","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T01:01:27Z","timestamp":1599008487000},"page":"1449-1455","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":3,"title":["A m\u00e1jbetegs\u00e9gek kialakul\u00e1s\u00e1nak \u00faj szempontjai \u2013 k\u00fcl\u00f6n\u00f6s tekintettel az autophagi\u00e1ra \u00e9s a mikro-RNS szerep\u00e9re"],"prefix":"10.1556","volume":"161","author":[{"given":"Kl\u00e1ra","family":"Werling","sequence":"first","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Hematol\u00f3gai Klinika, Semmelweis Egyetem, Budapest, Szentkir\u00e1lyi u. 46., 1088"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/35\/article-p1449.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/35\/article-p1449.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:12:58Z","timestamp":1633914778000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/35\/article-p1449.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":0,"journal-issue":{"issue":"35"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31834","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}