{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T22:06:55Z","timestamp":1748470015009},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"39","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,9,27]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n                <jats:p><jats:italic>Bevezet\u00e9s:<\/jats:italic> Az \u0151rszemnyirokcsom\u00f3-biopszia (SNB) jelent\u0151s\u00e9ge az\n                    el\u0151rehaladott \u2013 4 mm-n\u00e9l vastagabb \u2013 melanom\u00e1k kezel\u00e9s\u00e9ben eddig vitatott volt a\n                    szakirodalomban. Manaps\u00e1g azonban az adjuv\u00e1ns ter\u00e1pi\u00e1k alkalmaz\u00e1s\u00e1nak\n                    el\u0151felt\u00e9tele a region\u00e1lis nyirokcsom\u00f3k \u00e9rintetts\u00e9g\u00e9nek sz\u00f6vettani igazol\u00e1sa.\n                    Ugyanakkor az SNB sz\u00fcks\u00e9gess\u00e9g\u00e9nek krit\u00e9riumai Magyarorsz\u00e1gon sem egys\u00e9gesek,\n                    van, ahol jelenleg a vastag melanom\u00e1k eset\u00e9n nem v\u00e9gzik el ezt a beavatkoz\u00e1st.\n                        <jats:italic>C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> Klinik\u00e1nkon az elm\u00falt \u00e9vekben konzekvensen\n                    elv\u00e9gezt\u00fck az \u0151rszemnyirokcsom\u00f3k vizsg\u00e1lat\u00e1t 4 mm-n\u00e9l vastagabb melanom\u00e1k eset\u00e9n\n                    is, \u00edgy \u00e9rdemesnek tartottuk \u00e9rt\u00e9kelni, hogy ebben a betegcsoportban milyen\n                    ar\u00e1nyban fordul el\u0151 a t\u00e1j\u00e9ki nyirokcsom\u00f3k klinikailag nem, sz\u00f6vettanilag viszont\n                    detekt\u00e1lhat\u00f3 \u00e1tt\u00e9te. <jats:italic>M\u00f3dszer:<\/jats:italic> A klinik\u00e1nkon 2007 \u00e9s 2011 k\u00f6z\u00f6tt\n                    melanom\u00e1val diagnosztiz\u00e1lt 1133 beteg k\u00f6z\u00fcl kiv\u00e1lasztottuk azokat a p\u00e1cienseket,\n                    akiknek 4 mm-n\u00e9l vastagabb primer tumoruk volt, \u00e9s retrospekt\u00edven \u00e9rt\u00e9kelt\u00fck a\n                    betegek demogr\u00e1fiai adatait, primer daganatuk klinikai, valamint sz\u00f6vettani\n                    jellegzetess\u00e9geit az \u0151rszemnyirokcsom\u00f3 sz\u00f6vettani param\u00e9tereinek f\u00fcggv\u00e9ny\u00e9ben.\n                        <jats:italic>Eredm\u00e9nyek:<\/jats:italic> Az 5 \u00e9ves id\u0151szakban 116 olyan, melanom\u00e1ban\n                    szenved\u0151 beteget diagnosztiz\u00e1ltunk, akin\u00e9l vastag melanoma ker\u00fclt seb\u00e9szi\n                    kimetsz\u00e9sre. 78 p\u00e1ciensn\u00e9l t\u00f6rt\u00e9nt SNB, mely 50 esetben sz\u00f6vettanilag pozit\u00edvnak\n                    bizonyult. A betegek \u00e1tlagos \u00e9letkora k\u00f6zel 58 \u00e9v volt.\n                        <jats:italic>K\u00f6vetkeztet\u00e9s:<\/jats:italic> Klinik\u00e1nkon \u00e9vente t\u00edz olyan, vastag\n                    melanom\u00e1s beteget kezel\u00fcnk, akin\u00e9l az \u0151rszemnyirokcsom\u00f3 sz\u00f6vettani pozitivit\u00e1sa\n                    alapj\u00e1n igazoltuk a betegs\u00e9g metastaticus st\u00e1dium\u00e1t. Eredm\u00e9nyeink \u00e9s a Nemzeti\n                    R\u00e1kregiszter adatai alapj\u00e1n ak\u00e1r 100 k\u00f6r\u00fclire becs\u00fclhet\u0151 azoknak a p\u00e1cienseknek\n                    a sz\u00e1ma Magyarorsz\u00e1gon, akikn\u00e9l ezzel a patol\u00f3giai st\u00e1diumot meghat\u00e1roz\u00f3\n                    m\u00f3dszerrel az adjuv\u00e1ns kezel\u00e9s sz\u00fcks\u00e9gess\u00e9ge meg\u00e1llap\u00edthat\u00f3. A betegcsoport\n                    fiatal \u00e9letkor\u00e1t figyelembe v\u00e9ve, hat\u00e9kony target\/immunter\u00e1pia adjuv\u00e1ns\n                    alkalmaz\u00e1s\u00e1val eredm\u00e9nyesebben cs\u00f6kkenthet\u0151 lehet az elvesztett \u00e9let\u00e9vek sz\u00e1ma,\n                    mint a belszervi metastaticus st\u00e1diumban megkezdett kezel\u00e9sekkel. Orv Hetil.\n                    2020; 161(39): 1675\u20131680.<\/jats:p>","DOI":"10.1556\/650.2020.31835","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T01:02:01Z","timestamp":1601427721000},"page":"1675-1680","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Az \u0151rszemnyirokcsom\u00f3-\u00e1tt\u00e9t kimutat\u00e1sa 4 mm-n\u00e9l vastagabb melanom\u00e1ban es\u00e9lyt ad \u00edg\u00e9retes adjuv\u00e1ns kezel\u00e9sre"],"prefix":"10.1556","volume":"161","author":[{"given":"\u00c1d\u00e1m","family":"Kocsis","sequence":"first","affiliation":[{"name":"1 B\u0151rgy\u00f3gy\u00e1szati \u00e9s Allergol\u00f3giai Klinika, Szegedi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szeged, Kor\u00e1nyi fasor 6., 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