{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:58:07Z","timestamp":1649152687367},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"38","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Absztrakt: <\/jats:title>\n                <jats:p>A fenntart\u00f3 kezel\u00e9sm\u00f3dok els\u0151sorban a gyermekkori akut lymphoid leukaemi\u00e1ban\n                    voltak \u00e1ltal\u00e1nosak, feln\u0151ttkorban ritk\u00e1bbak. Fokozatosan alakultak ki fenntart\u00f3\n                    kezel\u00e9si m\u00f3dok n\u00e9h\u00e1ny feln\u0151ttkori hematol\u00f3giai betegs\u00e9gben, p\u00e9ld\u00e1ul n\u00e9h\u00e1ny\n                    lymphom\u00e1ban \u2013 p\u00e9ld\u00e1ul follicularis lymphoma, k\u00f6penysejtes lymphoma \u2013, s az\n                    elm\u00falt \u00e9vekben a myeloma fenntart\u00f3 kezel\u00e9se egyre jelent\u0151sebb teret nyert. M\u00e1ra\n                    egyre t\u00f6bb onkohematol\u00f3giai entit\u00e1s fenntart\u00f3 kezel\u00e9se egyre er\u0151s\u00f6d\u0151 tendencia,\n                    sokszor a kezdetben csak az indukci\u00f3s vagy relapsusos esetekben hat\u00e9konynak\n                    bizonyul\u00f3 kis molekul\u00e1k el\u0151t\u00e9rbe ker\u00fcl\u00e9se v\u00e1rhat\u00f3 fenntart\u00f3 k\u00e9sz\u00edtm\u00e9nyk\u00e9nt is.\n                    Myelom\u00e1ban a progn\u00f3zisf\u00fcgg\u0151 fenntart\u00f3 kezel\u00e9si m\u00f3d, mely gyakran ak\u00e1r a\n                    visszaes\u00e9sig tart, m\u00e1ra minden nemzetk\u00f6zi \u00e9s komolyabb aj\u00e1nl\u00e1s r\u00e9sze. Az elm\u00falt\n                    \u00e9vekben megjelentek fenntart\u00f3 kezel\u00e9si m\u00f3dok a feln\u0151ttkori akut myeloid\n                    leukaemi\u00e1ban is, teljesen \u00faj elemk\u00e9nt ak\u00e1r transzplant\u00e1ci\u00f3t k\u00f6vet\u0151en, ak\u00e1r a\n                    n\u00e9lk\u00fcl. Megv\u00e1ltozott az a szeml\u00e9let, hogy egy neh\u00e9z kemoter\u00e1pia vagy \u00e9ppen a\n                    csontvel\u0151-\u00e1t\u00fcltet\u00e9s az\u00e9rt is j\u00f3, mert ut\u00e1na kezel\u00e9smentess\u00e9 v\u00e1lhat a betegek\n                    t\u00falnyom\u00f3 r\u00e9sze. Fontos az is, hogy a fenntart\u00f3 kezel\u00e9s ne legyen megterhel\u0151, ne\n                    kelljen t\u00fal sok id\u0151t a k\u00f3rh\u00e1zban t\u00f6lteni, min\u00e9l ink\u00e1bb egyszer\u0171, ak\u00e1r tablett\u00e1s\n                    form\u00e1j\u00fa lehessen. Vannak tendenci\u00e1k arra, hogy az indukci\u00f3, a konszolid\u00e1ci\u00f3 \u00e9s a\n                    fenntart\u00f3 kezel\u00e9s (p\u00e9ld\u00e1ul a myeloma egyes esetei) egyre ink\u00e1bb kontinuumot\n                    k\u00e9pezzenek. Orv Hetil. 2020; 161(38): 1623\u20131628.<\/jats:p>","DOI":"10.1556\/650.2020.31853","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T01:02:02Z","timestamp":1600218122000},"page":"1623-1628","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":0,"title":["Fenntart\u00f3 kezel\u00e9si m\u00f3dok feln\u0151ttkori rosszindulat\u00fa hematol\u00f3giai betegs\u00e9gekben"],"prefix":"10.1556","volume":"161","author":[{"given":"Mikl\u00f3s","family":"Udvardy","sequence":"first","affiliation":[{"name":"\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Hematol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Debrecen, Nagyerdei krt. 98., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/38\/article-p1623.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/38\/article-p1623.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:14:19Z","timestamp":1633914859000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/38\/article-p1623.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":0,"journal-issue":{"issue":"38"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31853","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}