{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:40:31Z","timestamp":1760546431422},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"45","license":[{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,11,8]]},"abstract":"\u00d6sszefoglal\u00f3.<\/jats:bold> Bevezet\u00e9s:<\/jats:italic> Az atorvasztatin (koleszterincs\u00f6kkent\u0151), nifedipin\n (Ca2+<\/jats:sup>-antagonista), kaptopril (angiotenzinkonvert\u00e1z-g\u00e1tl\u00f3)\n vegy\u00fcletek a magas v\u00e9rnyom\u00e1s komplex kezel\u00e9s\u00e9nek \u201ealap\u201dgy\u00f3gyszerei. Mindh\u00e1rom\n antioxid\u00e1ns is. C\u00e9lkit\u0171z\u00e9s:<\/jats:italic> A tanulm\u00e1ny c\u00e9lja annak\n megv\u00e1laszol\u00e1sa volt, hogy e molekul\u00e1k g\u00e1tolhatj\u00e1k-e a v\u00e9rsejtek\n fagocitam\u0171k\u00f6d\u00e9s\u00e9t. Betegek \u00e9s m\u00f3dszer:<\/jats:italic> Magas v\u00e9rnyom\u00e1sos\n betegek: 15 f\u0151, 39\u201380 \u00e9ves, n\u0151: 6, f\u00e9rfi: 9. Eg\u00e9szs\u00e9ges kontroll: 7 f\u0151, 30\u201375\n \u00e9ves, n\u0151: 3, f\u00e9rfi: 4. A vizsg\u00e1lat a t\u00e9li h\u00f3napokban zajlott. A zimoz\u00e1n-\n (Saccharomyces cerevisiae)<\/jats:italic> r\u00e9szecsk\u00e9k fagocit\u00f3zisa sor\u00e1n\n k\u00e9pz\u0151d\u0151 kemilumineszcencia m\u00e9r\u00e9se perif\u00e9ri\u00e1s v\u00e9rben a gy\u00f3gyszerek jelenl\u00e9t\u00e9ben\n t\u00f6rt\u00e9nt luminom\u00e9terrel. A g\u00e1tl\u00e1st a stimul\u00e1ci\u00f3s index \u00e9rt\u00e9k\u00e9nek cs\u00f6kken\u00e9s\u00e9vel\n jellemezt\u00fck. Eredm\u00e9nyek:<\/jats:italic> Mindh\u00e1rom vegy\u00fclet g\u00e1tolta a\n kemilumineszcenci\u00e1t (oxig\u00e9nszabadgy\u00f6k-k\u00e9pz\u00e9st) a 65 \u00e9v feletti, magas\n v\u00e9rnyom\u00e1sos betegek t\u00f6bbs\u00e9g\u00e9ben: 11\/13 f\u0151n\u00e9l. F\u0151leg magasabb \u00e9letkorban \u00e9s\n cukorbetegs\u00e9gben, de m\u00e1s t\u00e1rsbetegs\u00e9gekben n\u0151tt a g\u00e1tl\u00e1s.\n K\u00f6vetkeztet\u00e9s:<\/jats:italic> Az id\u0151s, magas v\u00e9rnyom\u00e1sos betegek fokozott\n orvosi figyelmet ig\u00e9nyelnek a t\u00e9li id\u0151szakokban, mivel antioxid\u00e1ns hat\u00e1ssal is\n rendelkez\u0151 \u201ealap\u201dgy\u00f3gyszereiknek, egy\u00e9nt\u0151l f\u00fcgg\u0151en, lehetnek g\u00e1tl\u00f3 hat\u00e1saik a\n fagocit\u00e1k mikroba\u00f6l\u0151, oxig\u00e9nszabadgy\u00f6k-termel\u0151 k\u00e9pess\u00e9g\u00e9re. Orv Hetil. 2020;\n 161(45): 1908\u20131913.<\/jats:p>\n Summary.<\/jats:bold> Introduction:<\/jats:italic> Atorvastatin (cholesterol synthesis blocker),\n nifedipine (Ca2+<\/jats:sup> antagonist), captopril (angiotensin-convertase\n inhibitor) are basic drugs in the therapy of hypertension. They are also\n antioxidants. Objective:<\/jats:italic> To investigate whether these molecules\n can inhibit the phagocytic activity of peripheral blood cells. Patients\n and method:<\/jats:italic> Hypertension group: 15 patients with ages between 39\u201380\n years (6 women and 9 men). Healthy control group: 7 individuals with ages\n between 30\u201375 years (3 women and 4 men). The study was carried out in\n wintertime. The measurement of phagocytic activity was carried out by\n luminometry in peripheral blood samples. Chemiluminescence intensities were\n determined by the engulfment of zymosan (Saccharomyces\n cerevisiae)<\/jats:italic> particles in the presence of drugs. The inhibitory\n effects were characterized by the decreased values of the stimulation index.\n Results:<\/jats:italic> All three substances decreased the\n chemiluminescence (reactive oxygen species production) in the majority of\n samples from hypertensive patients over 65 years: in 11 of 13 patients. Stronger\n inhibition was detected in older, diabetic patients with other co-morbidities,\n too. Conclusion:<\/jats:italic> Older patients with hypertension require a\n special attention in wintertime. Antihypertensive drugs with antioxidant\n capabilities may have individually different inhibitory effects on the\n production of reactive oxygen species by phagocytes, which decreases their\n antimicrobial potency. Orv Hetil. 2020; 161(45): 1908\u20131913.<\/jats:p>","DOI":"10.1556\/650.2020.31856","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T01:01:29Z","timestamp":1605056489000},"page":"1908-1913","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Egyes, antioxid\u00e1ns mell\u00e9khat\u00e1s\u00fa \u201ev\u00e9rnyom\u00e1s\u201dgy\u00f3gyszerek hat\u00e1sa magas v\u00e9rnyom\u00e1sban szenved\u0151 \u00e9s eg\u00e9szs\u00e9ges szem\u00e9lyek v\u00e9rsejtjeinek fagocitakemilumineszcenci\u00e1j\u00e1ra in vitro"],"prefix":"10.1556","volume":"161","author":[{"given":"S\u00e1ndor","family":"Sipka","sequence":"first","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Debrecen, M\u00f3ricz Zsigmond u. 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Nagy","sequence":"additional","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai Immunol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Debrecen, M\u00f3ricz Zsigmond u. 22., 4032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Szentmikl\u00f3si","sequence":"additional","affiliation":[{"name":"2 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Farmakol\u00f3giai \u00e9s Farmakoter\u00e1piai Int\u00e9zet, Debreceni Egyetem, Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"3 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Farmakol\u00f3giai \u00e9s Farmakoter\u00e1piai Int\u00e9zet, P\u00e9csi Tudom\u00e1nyegyetem, P\u00e9cs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"4 Debrecen V\u00e1rosi Eg\u00e9szs\u00e9g\u00fcgyi Szolg\u00e1lat, Debreceni Egyetem, Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/45\/article-p1908.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/45\/article-p1908.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:13:43Z","timestamp":1633914823000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/45\/article-p1908.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,8]]},"references-count":0,"journal-issue":{"issue":"45"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.31856","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,8]]}}}