{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:54:01Z","timestamp":1769756041770,"version":"3.49.0"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"44","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A sz\u00e9kletmikrobiota-transzplant\u00e1ci\u00f3\n                    (faecalismikrobiota-transzplant\u00e1ci\u00f3 \u2013 FMT) a <jats:italic>Clostridioides\n                        difficile<\/jats:italic> fert\u0151z\u00e9s (CDI) kezel\u00e9s\u00e9ben nemzetk\u00f6zileg sz\u00e9les k\u00f6rben\n                    elfogadott, megfelel\u0151 szakmai h\u00e1tt\u00e9r mellett v\u00e9gezve biztons\u00e1gos, potenci\u00e1lisan\n                    \u00e9letment\u0151, k\u00f6lts\u00e9ghat\u00e9kony, valamint a hospitaliz\u00e1ci\u00f3s id\u0151 \u00e9s az orvos-beteg\n                    tal\u00e1lkoz\u00e1sok jelent\u0151s reduk\u00e1l\u00e1s\u00e1ra k\u00e9pes elj\u00e1r\u00e1s. Az FMT elv\u00e9gz\u00e9s\u00e9re egyes\n                    orsz\u00e1gokban magas szint\u0171 min\u0151s\u00e9gir\u00e1ny\u00edt\u00e1si h\u00e1tt\u00e9rrel m\u0171k\u00f6d\u0151, c\u00e9lfeladatra\n                    szervez\u0151d\u00f6tt donor- \u00e9s sz\u00e9kletbankok rendezkedtek be. M\u00e1shol, \u00edgy p\u00e9ld\u00e1ul\n                    haz\u00e1nkban, az elj\u00e1r\u00e1shoz az egy\u00e9rtelm\u0171 jogi szab\u00e1lyoz\u00e1si k\u00f6rnyezet, a\n                    standardiz\u00e1lt technol\u00f3giai h\u00e1tt\u00e9r \u00e9s a finansz\u00edroz\u00e1s hi\u00e1nya miatt nem egys\u00e9ges a\n                    hozz\u00e1f\u00e9r\u00e9s. R\u00e9g\u00f3ta id\u0151szer\u0171 tov\u00e1bb\u00e1, hogy a heterog\u00e9n, nemegyszer h\u00e1ztart\u00e1si\n                    eszk\u00f6z\u00f6kkel el\u0151k\u00e9sz\u00edtett beavatkoz\u00e1sok helyett a nemzetk\u00f6zi \u00e9s leg\u00fajabban m\u00e1r a\n                    hazai aj\u00e1nl\u00e1sokban is megfogalmazott, a betegbiztons\u00e1got legjobban garant\u00e1l\u00f3\n                    elv\u00e1r\u00e1sok mellett t\u00f6rt\u00e9njen a sz\u00e9klettranszplant\u00e1ci\u00f3. Az \u00faj koronav\u00edrus\n                    (SARS-CoV-2) okozta pand\u00e9mia megjelen\u00e9se er\u0151teljes szakmai \u00e9rv orsz\u00e1gos szinten\n                    az FMT min\u0151s\u00e9gir\u00e1ny\u00edt\u00e1si k\u00f6rnyezet\u00e9nek \u00e9s technol\u00f3giai h\u00e1tter\u00e9nek\n                    \u00fajragondol\u00e1s\u00e1ra, mert a SARS-CoV-2 egyszerre jelent kock\u00e1zatot a CDI miatt\n                    k\u00f3rh\u00e1zban kezelt s\u00e9r\u00fcl\u00e9keny betegpopul\u00e1ci\u00f3nak, \u00e9s egyben vesz\u00e9lyezteti az FMT\n                    biztons\u00e1goss\u00e1g\u00e1t mind a recipiens, mind pedig az elj\u00e1r\u00e1st v\u00e9gz\u0151 eg\u00e9szs\u00e9g\u00fcgyi\n                    szem\u00e9lyzet tekintet\u00e9ben. Ezekre a szakmai \u00e9s t\u00e1rsadalmi kih\u00edv\u00e1sokra reag\u00e1lva, a\n                    sz\u00e9les k\u00f6r\u0171 beteghozz\u00e1f\u00e9r\u00e9s \u00e9s a legmagasabb szint\u0171 betegbiztons\u00e1g\n                    garant\u00e1l\u00e1s\u00e1ra, a Debreceni Egyetemen \u00faj elj\u00e1r\u00e1srendet dolgoztunk ki az FMT\n                    v\u00e9gz\u00e9s\u00e9re. Ezen elj\u00e1r\u00e1srendnek a COVID\u201319-pand\u00e9mia miatt m\u00f3dos\u00edtott, a\n                    fagyasztottgraftbank \u00fczemeltet\u00e9se \u00e9s a rendszerszeml\u00e9let tekintet\u00e9ben relev\u00e1ns\n                    elemeit ismertetj\u00fck. Javasolt, hogy orsz\u00e1gos szinten hasonl\u00f3, megfelel\u0151\n                    min\u0151s\u00e9gir\u00e1ny\u00edt\u00e1si \u00e9s technol\u00f3giai k\u00f6rnyezettel, a SARS-CoV-2-fert\u0151z\u00e9s kiz\u00e1r\u00e1s\u00e1t\n                    is integr\u00e1l\u00f3 donorsz\u0171r\u00e9si rendszerrel, tov\u00e1bb\u00e1 fagyasztottgraft-banki h\u00e1tt\u00e9rrel\n                    m\u0171k\u00f6d\u0151 laborat\u00f3riumok vegyenek r\u00e9szt a sz\u00e9klettranszplant\u00e1ci\u00f3k v\u00e9gz\u00e9s\u00e9ben.\n                    Felmer\u00fcl tov\u00e1bb\u00e1, hogy az elj\u00e1r\u00e1st a sz\u00e1mos anal\u00f3gia \u00e9s a donor\u2013recipiens\n                    koncepci\u00f3 alapj\u00e1n a sejt- \u00e9s sz\u00f6vettranszplant\u00e1ci\u00f3kra vonatkoz\u00f3\n                    szab\u00e1lyoz\u00f3rendszer keretei k\u00f6z\u00e9 aj\u00e1nlott be\u00e1gyazni. Orv Hetil. 2020; 161(44):\n                    1858\u20131871.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> Stool transplantation (faecal microbiota transplantation \u2013\n                    FMT) is a widely accepted, potentially life-saving, cost-effective medical\n                    intervention for the treatment of <jats:italic>Clostridioides difficile<\/jats:italic>\n                    infection (CDI), which has an acceptable safety profile if performed with an\n                    appropriate professional background. FMT can significantly reduce\n                    hospitalization time and the number of patient visits. National donor and stool\n                    banks with high-standard quality management systems were established in certain\n                    countries for supporting the procedures. In other regions, including Hungary,\n                    patient access is not uniform due to the lack of clear legal regulations,\n                    standardized technology or financial reimbursement. It has been expected for a\n                    long time to replace the heterogenous techniques, occasionally utilizing\n                    household equipment with a technology providing improved patient safety and\n                    fulfilling international and recently published local FMT guidelines. The\n                    emergence of the novel coronavirus (SARS-CoV-2) pandemic is a very powerful\n                    argument in favour of urgently reconsidering the quality management and\n                    technological background of FMT procedures. SARS-CoV-2 is a major threat to the\n                    vulnerable patients suffering from CDI and also impose risks for the recipient\n                    and healthcare personnel involved in carrying out the transplantation. New FMT\n                    guidelines were implemented at the University of Debrecen to address these\n                    professional and public challenges, to provide wide patient access and to\n                    guarantee the highest achievable patient safety. Relevant elements of this new\n                    protocol are presented, focusing on a systemic quality management approach, on\n                    the operation of a frozen stool bank and on a modified donor screening algorithm\n                    taking the risks of COVID-19 into consideration. We suggest that laboratories\n                    with proper quality assurance and technological conditions, implementing\n                    SARS-CoV-2 donor screening and operating a frozen graft bank should participate\n                    in faecal microbiota transplantations. It is also recommended that, based on the\n                    analogies and the similar donor\u2013recipient concept, FMT should be embedded under\n                    the organ tissue and cell transplantation polices in Hungary. Orv Hetil. 2020;\n                    161(44): 1858\u20131871.<\/jats:p>","DOI":"10.1556\/650.2020.32023","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T01:02:20Z","timestamp":1604451740000},"page":"1858-1871","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":3,"title":["A sz\u00e9kletmikrobiota-transzplant\u00e1ci\u00f3 technol\u00f3gi\u00e1j\u00e1nak \u00e9s min\u0151s\u00e9gir\u00e1ny\u00edt\u00e1si h\u00e1tter\u00e9nek \u00fajragondol\u00e1sa a SARS-CoV-2 v\u00edruspand\u00e9mia kapcs\u00e1n"],"prefix":"10.1556","volume":"161","author":[{"given":"Gergely Gy\u00f6rgy","family":"Nagy","sequence":"first","affiliation":[{"name":"1\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Debreceni Egyetem, Debrecen, Pf. 99, 4012"},{"name":"2 I. Belgy\u00f3gy\u00e1szat \u2013 Kardiol\u00f3giai Oszt\u00e1ly, Borsod-Aba\u00faj-Zempl\u00e9n Megyei K\u00f6zponti K\u00f3rh\u00e1z \u00e9s Egyetemi Oktat\u00f3k\u00f3rh\u00e1z, Miskolc"},{"name":"3 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Rektori Hivatal, Debreceni Egyetem, Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsa","family":"Tudlik","sequence":"additional","affiliation":[{"name":"4 Sejtter\u00e1pia Laborat\u00f3rium, Medyag Kft., Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Gergely","sequence":"additional","affiliation":[{"name":"1\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Debreceni Egyetem, Debrecen, Pf. 99, 4012"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"K\u00f3nya","sequence":"additional","affiliation":[{"name":"5 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai Int\u00e9zet, Debreceni Egyetem, Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piroska","family":"Orosi","sequence":"additional","affiliation":[{"name":"6 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, K\u00f3rh\u00e1zhigi\u00e9n\u00e9s Oszt\u00e1ly, Debreceni Egyetem, Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9va","family":"R\u00e1k\u00f3czi","sequence":"additional","affiliation":[{"name":"1\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Debreceni Egyetem, Debrecen, Pf. 99, 4012"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"5 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai Int\u00e9zet, Debreceni Egyetem, Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"V\u00e1rv\u00f6lgyi","sequence":"additional","affiliation":[{"name":"1\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Debreceni Egyetem, Debrecen, Pf. 99, 4012"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eszter","family":"Vit\u00e1lis","sequence":"additional","affiliation":[{"name":"6 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, K\u00f3rh\u00e1zhigi\u00e9n\u00e9s Oszt\u00e1ly, Debreceni Egyetem, Debrecen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gy\u00f6rgy","family":"Paragh","sequence":"additional","affiliation":[{"name":"1\u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Debreceni Egyetem, Debrecen, Pf. 99, 4012"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/44\/article-p1858.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/44\/article-p1858.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:12:38Z","timestamp":1633914758000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/44\/article-p1858.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":0,"journal-issue":{"issue":"44"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.32023","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}