{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:15:54Z","timestamp":1787022954678,"version":"build-2736575974"},"reference-count":0,"publisher":"Akademiai Kiado Zrt.","issue":"50","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2020,12,13]]},"abstract":"\n \u00d6sszefoglal\u00f3.<\/jats:bold>\n Bevezet\u00e9s:<\/jats:italic>\n Egy \u00faj, sz\u00e1m\u00edt\u00f3g\u00e9p \u00e1ltal seg\u00edtett\n betegminta-asszoci\u00e1ci\u00f3s anal\u00edzis eredm\u00e9nye szerint a COVID\u201319 t\u00fcneteinek\n kialak\u00edt\u00e1s\u00e1ban kiemelt t\u00e9nyez\u0151k\u00e9nt jelenik meg a bradikinin. Eszerint a\n bradikinin lebont\u00e1sa lelassul az angiotenzinkonvert\u00e1l\u00f3 enzim aktivit\u00e1s\u00e1nak\n cs\u00f6kken\u00e9se miatt, ami jelent\u0151sen megemelked\u0151 bradikininszinthez vezet a t\u00fcd\u0151ben.\n Nem mer\u00fclt fel azonban a v\u00e9ralvad\u00e1si faktorok lehets\u00e9ges szerepe a\n \u201ebradikininviharban\u201d, annak ellen\u00e9re, hogy az id\u0151sebb cardiovascularis\n betegekben aktiv\u00e1l\u00f3d\u00f3 XII-es faktor \u00e9s a C1-\u00e9szter\u00e1z-inhibitor (C1INH) alacsony\n szintje nagy mennyis\u00e9g\u0171 bradikinin k\u00e9pz\u0151d\u00e9s\u00e9hez vezethet.\n M\u00f3dszer:<\/jats:italic>\n \u00c1tfog\u00f3 irodalmi \u00e1ttekint\u00e9s.\n Eredm\u00e9nyek:<\/jats:italic>\n 1) A v\u00edrus \u00e1ltal fert\u0151z\u00f6tt, s\u00e9r\u00fclt\n endotheliumsejtek fel\u00fclete az a hely, amellyel \u00e9rintkezve elindulhat a XII-es\n v\u00e9ralvad\u00e1si faktor aktiv\u00e1ci\u00f3ja \u2013 ez serkenti a prekallikrein\/kallikrein\/kinin\n rendszert, \u00e9s bradikinink\u00e9pz\u0151d\u00e9st okoz. Ez a folyamat megt\u00f6rt\u00e9nik a s\u00falyos vese-\n \u00e9s t\u00fcd\u0151k\u00e1rosod\u00e1st okoz\u00f3 hantav\u00edrus-fert\u0151z\u00e9sekben. 2) Id\u0151s betegekben az\n atherosclerosis miatt t\u00f6bbsz\u00f6r\u00f6sen s\u00e9r\u00fclt, merev, \u201estiff\u201d erek\n endotheliumfelsz\u00ednein j\u00f3val magasabb lehet a XII-es faktor kontakt \u00faton t\u00f6rt\u00e9n\u0151\n aktiv\u00e1ci\u00f3ja, mint a fiatal egy\u00e9nek ereiben. Ez a t\u00e9ny egyik oka lehet az id\u0151s,\n cardiovascularis betegek k\u00f6r\u00e9ben tapasztalt magasabb hal\u00e1loz\u00e1snak.\n K\u00f6vetkeztet\u00e9s:<\/jats:italic>\n Az aktiv\u00e1lt XII-es v\u00e9ralvad\u00e1si faktor\n c\u00e9lzott g\u00e1tl\u00e1sa \u00fajabb gy\u00f3gy\u00edt\u00e1si lehet\u0151s\u00e9g lehet a SARS-CoV-2-fert\u0151z\u00f6tt id\u0151s\n betegekben. Jelenleg m\u00e1r hat\u00e1sosnak bizonyult a bradikinink\u00e9pz\u00e9st g\u00e1tl\u00f3\n C1INH-nak, tov\u00e1bb\u00e1 a bradikininreceptor-g\u00e1tl\u00f3knak az ad\u00e1sa is. Orv Hetil. 2020;\n 161(50): 2099\u20132103.\n <\/jats:p>\n \n Summary.<\/jats:bold>\n Introduction:<\/jats:italic>\n Bradykinin was implicated in a new complex model\n of pathomechanism leading to the symptoms of COVID-19 created by a\n computer-assisted association analysis. According to this model, the decrease in\n angiotensin-converting enzyme expression leads to impaired bradykinin\n elimination and subsequent enrichment in the lungs. However, there is no\n mentioning of the importance of blood coagulation factor XII in increased\n bradykinin production, in spite of its age-dependent activation and the lower\n level of C1-esterase inhibitor (C1INH). Activated factor XII may be an important\n contributor to the \u201cbradykinin storm\u201d in elder cardiovascular patients.\n Method:<\/jats:italic>\n Literature review.\n Results:<\/jats:italic>\n 1)\n Activation of the coagulation factor XII on the surface of SARS-CoV-2 infected\n endothelial cells may trigger the prekallikrein\/kallikrein\/kinin system\n producing bradykinin. Such process is taking place in hantavirus infections\n causing severe lung and kidney damages. 2) The endothelial system is\n dysregulated in elderly patients, resulting in potentially higher factor XII\n activities on the surface of damaged endothelial cells in the stiffened\n arteries. This can contribute to the higher mortality rates in the elderly.\n Conclusion:<\/jats:italic>\n The targeted inhibition of activated blood\n coagulation factor XII may represent a new therapeutic target for COVID-19,\n especially for elder patients. Recently, beneficial results have already been\n observed by the clinical applications of recombinant C1INH and bradykinin\n receptor antagonists. Orv Hetil. 2020; 161(50): 2099\u20132103.\n <\/jats:p>","DOI":"10.1556\/650.2020.32075","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T20:03:42Z","timestamp":1608062622000},"page":"2099-2103","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":3,"title":["A fel\u00fcletaktiv\u00e1lt XII-es v\u00e9ralvad\u00e1si faktor \u00e9letkort\u00f3l f\u00fcgg\u0151 lehets\u00e9ges szerepe a \u201ebradikininvihar\u201d kialak\u00edt\u00e1s\u00e1ban COVID\u201319-betegekben"],"prefix":"10.1556","volume":"161","author":[{"given":"S\u00e1ndor","family":"Sipka","sequence":"first","affiliation":[{"name":"1 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai Immunol\u00f3giai Tansz\u00e9k, Belgy\u00f3gy\u00e1szati Int\u00e9zet, Debreceni Egyetem, Debrecen, M\u00f3ricz Zs. u. 22., 4032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"2 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai Fiziol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Debrecen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Sipka jr.","sequence":"additional","affiliation":[{"name":"3 \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Kardiol\u00f3giai Int\u00e9zet, Kardiol\u00f3giai Tansz\u00e9k, Debreceni Egyetem, Debrecen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/50\/article-p2099.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/161\/50\/article-p2099.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T21:12:47Z","timestamp":1633900367000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/161\/50\/article-p2099.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,13]]},"references-count":0,"journal-issue":{"issue":"50"},"URL":"https:\/\/doi.org\/10.1556\/650.2020.32075","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,13]]}}}