{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T05:26:11Z","timestamp":1782019571953,"version":"3.54.5"},"reference-count":58,"publisher":"Akademiai Kiado Zrt.","issue":"5","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,1,31]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> Gy\u00f3gyszereink egy r\u00e9sz\u00e9nek jelent\u0151s, az eredeti\n                    alkalmaz\u00e1st\u00f3l elt\u00e9r\u0151 hat\u00e1sa is van. Ezek felismer\u00e9se fontos, hogy elker\u00fclj\u00fck a\n                    nem v\u00e1rt mell\u00e9khat\u00e1sokat, vagy kihaszn\u00e1ljuk ezeket a kedvez\u0151 adotts\u00e1gokat. A\n                    helyi \u00e9rz\u00e9stelen\u00edt\u0151k antibakteri\u00e1lis hat\u00e1sa 1909 \u00f3ta ismert, de ennek t\u00f6bb\n                    \u00e9vtizeden kereszt\u00fcl nem tulajdon\u00edtottak jelent\u0151s\u00e9get. Az 1960-as \u00e9vekben\n                    figyeltek fel el\u0151sz\u00f6r az \u00e1lnegat\u00edv mikrobiol\u00f3giai eredm\u00e9nyek lehet\u0151s\u00e9g\u00e9re, helyi\n                    \u00e9rz\u00e9stelen\u00edt\u0151ket haszn\u00e1lva a mintav\u00e9telhez. Tanulm\u00e1nyok igazolt\u00e1k, hogy a\n                    bronchoszk\u00f3pi\u00e1s, seb-, b\u0151r- vagy f\u00fcl-, orr-, g\u00e9g\u00e9szeti bakteriol\u00f3giai eredm\u00e9nyek\n                    is \u00e9rintve lehetnek. A ma is haszn\u00e1lt gy\u00f3gyszerek k\u00f6z\u00fcl a 0,5%-os bupivakainnak\n                    \u00e9s a 2%-os lidokainnak van jelent\u0151s antibakteri\u00e1lis hat\u00e1sa Gram-pozit\u00edv \u00e9s\n                    Gram-negat\u00edv bakt\u00e9riumokkal szemben, ami kifejezettebb 37 \u00b0C-on, mint\n                    szobah\u0151m\u00e9rs\u00e9kleten. A leger\u0151sebb antibakteri\u00e1lis hat\u00e1st a 0,5%-os bupivakain\n                    mutatta. A napi gyakorlatban alkalmazott koncentr\u00e1ci\u00f3juk magasabb, mint a\n                    k\u00fcl\u00f6nb\u00f6z\u0151 klinikai izol\u00e1tumokkal szemben meghat\u00e1rozott minim\u00e1lis g\u00e1tl\u00f3\n                    koncentr\u00e1ci\u00f3. Fenti tulajdons\u00e1gaik alapj\u00e1n felmer\u00fclt szerep\u00fck a k\u00f3rh\u00e1zi\n                    sebfert\u0151z\u00e9sek cs\u00f6kkent\u00e9s\u00e9ben is. A hat\u00e1smechanizmus t\u00f6bb pontja ismert,\n                    k\u00e1ros\u00edtj\u00e1k a sejth\u00e1rtya integrit\u00e1s\u00e1t, \u00e9s t\u00f6bb bakteri\u00e1lis enzim m\u0171k\u00f6d\u00e9s\u00e9t\n                    g\u00e1tolj\u00e1k. Orv Hetil. 2021; 162(5): 171\u2013176.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> Medications may have important impacts other than the\n                    original effect. It is important to know about these to avoid side effects or\n                    use these beneficial capabilities. The antibacterial effect of local\n                    anaesthetics has been known since 1909. For decades, no attention has been payed\n                    to this fact. In the 1960s, the high number of negative microbiological results\n                    when local anaesthetics were used before sampling drew attention to the possible\n                    antibacterial effect. Studies suggested that cultures from bronchoscopy, wound,\n                    skin or nasal samples may be affected. Bupivacaine 0,5% and lidocaine 2% have\n                    the most noticeable effect against both Gram-positive and Gram-negative\n                    bacteria. This impact is more pronounced at 37 \u00b0C than at room temperature.\n                    Bupivacaine 0,5% has the most pronounced effect. The concentration of local\n                    anaesthetics in daily routine is higher than the minimal inhibitory\n                    concentration against various clinical isolates. In the view of these results,\n                    they may contribute to reduce surgical site infections. There are known details\n                    regarding the mechanism of action. Local anaesthetics have target sites on\n                    cellular membrane and inhibit bacterial enzymes. Orv Hetil. 2021; 162(5):\n                    171\u2013176.<\/jats:p>","DOI":"10.1556\/650.2021.32002","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T12:09:43Z","timestamp":1617106183000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":5,"title":["Helyi \u00e9rz\u00e9stelen\u00edt\u0151k antibakteri\u00e1lis hat\u00e1sa"],"prefix":"10.1556","volume":"162","author":[{"given":"Zolt\u00e1n","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet, P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 13., 7623"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Szentkir\u00e1lyi","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai Int\u00e9zet, P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"3 Zala Megyei Szent Rafael K\u00f3rh\u00e1z, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Oszt\u00e1ly, Zalaegerszeg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6rs","family":"Gy\u0151rffy","sequence":"additional","affiliation":[{"name":"3 Zala Megyei Szent Rafael K\u00f3rh\u00e1z, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Oszt\u00e1ly, Zalaegerszeg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"S\u00fct\u0151","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet, P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 13., 7623"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"B\u00e1tai","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Aneszteziol\u00f3giai \u00e9s Intenz\u00edv Ter\u00e1pi\u00e1s Int\u00e9zet, P\u00e9cs, Ifj\u00fas\u00e1g \u00fatja 13., 7623"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Ker\u00e9nyi","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Klinikai K\u00f6zpont, Orvosi Mikrobiol\u00f3giai Int\u00e9zet, P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"issue":"2","key":"ref0","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/S0140-6736(02)28859-5","article-title":"On the use of cocaine for producing anaesthesia on the eye","volume":"124","author":"1 Koller","year":"1884","unstructured":"1 Koller C. 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