{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T08:31:45Z","timestamp":1723192305738},"reference-count":14,"publisher":"Akademiai Kiado Zrt.","issue":"13","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,3,28]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> K\u00f6zlem\u00e9ny\u00fcnkben egy 63 \u00e9ves f\u00e9rfi eset\u00e9t ismertetj\u00fck,\n                    aki f\u00e1rad\u00e9konys\u00e1g, fogy\u00e1s miatt v\u00e9gzett laborat\u00f3riumi vizsg\u00e1latokon igazol\u00f3d\u00f3\n                    veseel\u00e9gtelens\u00e9g \u00e9s hypercalcaemia miatt ker\u00fclt felv\u00e9telre Klinik\u00e1nkra. A\n                    ter\u00fcleten v\u00e9gzett r\u00f6ntgenvizsg\u00e1laton a kopony\u00e1n frontalisan \u00e9s a sacrumon\n                    csontelt\u00e9r\u00e9sek (temporofrontalisan 13 mm-es, k\u00f6r\u00fcl\u00edrtabb, m\u00e9rs\u00e9kelten intenz\u00edv\n                    \u00e1rny\u00e9k \u00e9s az S1-es r\u00e9s sclerosisa) \u00e1br\u00e1zol\u00f3dtak, ultrahangvizsg\u00e1lat sor\u00e1n\n                    l\u00e9pmegnagyobbod\u00e1s volt l\u00e1that\u00f3. T\u00fcnetei h\u00e1tter\u00e9ben endokrin vagy malignus\n                    betegs\u00e9g nem igazol\u00f3dott. A h\u00e1tt\u00e9rben els\u0151sorban myeloma multiplex mer\u00fclt fel,\n                    ugyanakkor azt c\u00e9lzott vizsg\u00e1latokkal sem meger\u0151s\u00edteni, sem kiz\u00e1rni nem\n                    lehetett, \u00edgy csontvel\u0151-biopszia t\u00f6rt\u00e9nt. A vesefunkci\u00f3-roml\u00e1s ok\u00e1nak tiszt\u00e1z\u00e1sa\n                    v\u00e9gett vesebiopszi\u00e1t v\u00e9gezt\u00fcnk, melynek el\u0151zetes eredm\u00e9nye interstitialis\n                    nephritist v\u00e9lem\u00e9nyezett \u00f3ri\u00e1ssejtekkel. Az angiotenzinkonvert\u00e1l\u00f3 enzim\n                    sz\u00e9rumszintj\u00e9nek ez okb\u00f3l t\u00f6rt\u00e9n\u0151 vizsg\u00e1lata emelkedett szintet mutatott, \u00edgy\n                    eset\u00fcnket Boeck-sarcoidosis extrapulmonalis manifeszt\u00e1ci\u00f3j\u00e1nak tartottuk.\n                        <jats:italic>Per os<\/jats:italic> szteroidkezel\u00e9sre a beteg t\u00fcnetei egy\u00e9rtelm\u0171\n                    regresszi\u00f3t mutattak. A csontvel\u0151- \u00e9s vesebiopszia eredm\u00e9nye meger\u0151s\u00edtette a\n                    Boeck-sarcoidosis diagn\u00f3zis\u00e1t. A sarcoidosis ezen extrapulmonalis form\u00e1ja\n                    hypercalcaemi\u00e1val \u00e9s vese\u00e9rintetts\u00e9ggel \u2013 de t\u00fcd\u0151\u00e9rintetts\u00e9g n\u00e9lk\u00fcl \u2013 rendk\u00edv\u00fcl\n                    ritka, k\u00fcl\u00f6n\u00f6s tekintettel a ves\u00e9t \u00e9rint\u0151 form\u00e1ra. Hypercalcaemia nagyj\u00e1b\u00f3l\n                    7,9%-ban, veseel\u00e9gtelens\u00e9g 1,4%-ban fordul el\u0151. Ezen eset alapj\u00e1n fontos\n                    hangs\u00falyozni, hogy a hypercalcaemia \u00e9s a veseel\u00e9gtelens\u00e9g h\u00e1tter\u00e9ben a gyakoribb\n                    endokrin, malignus, hematol\u00f3giai okok mellett a Boeck-sarcoidosisnak is fel kell\n                    mer\u00fclnie a differenci\u00e1ldiagnosztika sor\u00e1n. Orv Hetil. 2021; 162(13):\n                    514\u2013518.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> We present the case of a 63-year-old male patient who was\n                    admitted to our Clinic with fatigue, weight loss, hypercalcemia, renal\n                    insufficiency and anemia. X-ray showed lesions on the frontal skull and sacral\n                    region. On abdominal ultrasound, splenomegaly was detected. Based on these,\n                    myeloma multiplex was the most likely initial diagnosis; this, however, could\n                    not be confirmed with targeted serum tests, therefore bone marrow biopsy was\n                    performed. To clarify the underlying cause of decreased kidney function, renal\n                    biopsy was performed, the preliminary results of which revealed interstitial\n                    nephritis accompanied by giant cells. Serum angiotensin converting enzyme level\n                    was elevated, which led to the diagnosis of Boeck sarcoidosis with\n                    extrapulmonary manifestations. Oral corticosteroid therapy was commenced that\n                    was followed by regression of the patient\u2019s symptoms and laboratory\n                    abnormalities. Both the bone marrow and the kidney biopsies supported the\n                    diagnosis of Boeck sarcoidosis. Presentation of sarcoidosis with hypercalcemia\n                    and renal insufficiency but without the involvement of the lungs is extremely\n                    rare. Hypercalcemia occurs in about 7.9% and renal insufficiency in 1.4% of the\n                    cases. Based on this case, it is important to highlight that in the background\n                    of hypercalcemia and renal failure \u2013 beside the more frequent causes such as\n                    endocrine and hematological diseases, malignancy \u2013 one is to consider the\n                    possibility of Boeck sarcoidosis as well. Orv Hetil. 2021; 162(13): 514\u2013518.<\/jats:p>","DOI":"10.1556\/650.2021.32013","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T13:37:26Z","timestamp":1617025046000},"page":"514-518","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Hypercalcaemia \u00e9s veseel\u00e9gtelens\u00e9g \u2013 merre induljunk?"],"prefix":"10.1556","volume":"162","author":[{"given":"N\u00f3ra","family":"Garam","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika, Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Tisl\u00e9r","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika, Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1kos","family":"Peth\u0151","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika, Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00f3ra","family":"Led\u00f3","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika, Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika, Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Feh\u00e9r","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika, Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdolna","family":"Kardos","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, II. Patol\u00f3giai Int\u00e9zet, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Csomor","sequence":"additional","affiliation":[{"name":"3 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Patol\u00f3giai \u00e9s K\u00eds\u00e9rleti R\u00e1kkutat\u00f3 Int\u00e9zet, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Tak\u00e1cs","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Belgy\u00f3gy\u00e1szati \u00e9s Onkol\u00f3giai Klinika, Budapest, Kor\u00e1nyi S\u00e1ndor u. 2\/a, 1083"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clinbiochem.2018.06.010","article-title":"Focus on increased serum angiotensin-converting enzyme level: from granulomatous diseases to genetic mutations","volume":"59","author":"1 Lopez-Sublet","year":"2018","unstructured":"1 Lopez-Sublet M, Caratti di Lanzacco L, Danser AH, et al. Focus on increased serum angiotensin-converting enzyme level: from granulomatous diseases to genetic mutations. 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