{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T08:32:34Z","timestamp":1723192354887},"reference-count":50,"publisher":"Akademiai Kiado Zrt.","issue":"28","license":[{"start":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T00:00:00Z","timestamp":1625961600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,7,11]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A glut\u00e9n, aliment\u00e1ris k\u00f6rnyezeti antig\u00e9nk\u00e9nt,\n                    k\u00fcl\u00f6nb\u00f6z\u0151 szervrendszereket \u00e9rint\u0151 autoimmun betegs\u00e9geket tud kiv\u00e1ltani. A\n                    k\u00f3rk\u00e9pek h\u00e1tter\u00e9ben a glut\u00e9ntolerancia velesz\u00fcletett hi\u00e1nya vagy az \u00e9let sor\u00e1n\n                    bek\u00f6vetkez\u0151 elveszt\u00e9se \u00e1ll. A glut\u00e9ninduk\u00e1lt autoimmun betegs\u00e9gek k\u00f6z\u00f6tt a\n                    leggyakoribb a coeliakia, melyet k\u00fcl\u00f6nb\u00f6z\u0151 s\u00falyoss\u00e1g\u00fa enterop\u00e1tia jellemez, \u00e9s\n                    melynek a sz\u00f6veti, 2-es t\u00edpus\u00fa transzglutamin\u00e1z az autoantig\u00e9nje. A coeliakia\n                    extraintestinalis t\u00fcnetei k\u00f6z\u00f6tt azonban n\u00e9ha olyan b\u0151r- \u00e9s idegrendszeri\n                    k\u00f3rk\u00e9pek jellegzetess\u00e9gei is megtal\u00e1lhat\u00f3k, melyek h\u00e1tter\u00e9ben tov\u00e1bbi\n                    transzglutamin\u00e1z-autoimmunit\u00e1s kialakul\u00e1sa \u00e1ll. Idesorolhat\u00f3 a hevesen viszket\u0151,\n                    polimorf autoimmun b\u0151rbetegs\u00e9g, a dermatitis herpetiformis\n                    (transzglutamin\u00e1z-3-autoimmunit\u00e1s) \u00e9s a centr\u00e1lis \u00e9s\/vagy perif\u00e9ri\u00e1s neurol\u00f3giai\n                    k\u00e1rosod\u00e1sok egy jellegzetes csoportja (transzglutamin\u00e1z-6-autoimmunit\u00e1s). Az\n                    induk\u00e1lt autoimmunit\u00e1s reverzibilis, a szigor\u00faan tartott glut\u00e9nmentes di\u00e9ta\n                    mellett a coeliakia \u00e9s a b\u0151rt\u00fcnetek elm\u00falnak, de az idegrendszeri t\u00fcnetek egy\n                    r\u00e9sze maradand\u00f3. Az elm\u00falt \u00e9vtizedben besz\u00e1moltak glut\u00e9n\u00e9rz\u00e9keny,\n                    transzglutamin\u00e1z-6-pozit\u00edv, nem coeliaki\u00e1s (transzglutamin\u00e1z-2-negat\u00edv)\n                    betegekr\u0151l is. A glut\u00e9nszenzitivit\u00e1s sokf\u00e9le megjelen\u00e9s\u00e9t ma is er\u0151sen kutatj\u00e1k.\n                    Fontos a korai felismer\u00e9s \u00e9s a k\u00f3rk\u00e9pek interdiszciplin\u00e1ris szeml\u00e9let\u0171 kezel\u00e9se.\n                    A coeliakia csal\u00e1di sz\u0171r\u0151vizsg\u00e1latokkal val\u00f3 korai felismer\u00e9se \u00e9s a t\u00fcnetmentes\n                    egy\u00e9nek di\u00e9t\u00e1s kezel\u00e9se is nagy jelent\u0151s\u00e9g\u0171 a glut\u00e9n\u00e9rz\u00e9kenys\u00e9g \u00e1ltal kiv\u00e1ltott\n                    hi\u00e1ny\u00e1llapotok \u00e9s a t\u00e1rsul\u00f3 egy\u00e9b betegs\u00e9gek kialakul\u00e1s\u00e1nak megel\u0151z\u00e9s\u00e9ben. Orv\n                    Hetil. 2021; 162(28): 1107\u20131118.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> Autoimmune diseases induced by digestion of gluten, an\n                    environmental antigen, can affect different organ systems. The diseases develop\n                    in individuals with congenital or acquired loss of gluten tolerance for life.\n                    Amongst the gluten-induced autoimmune diseases, celiac disease is the most\n                    common one, characterized by an enteropathy of varying severity. Here the target\n                    autoantigen is tissue (type 2) transglutaminase. While the extraintestinal\n                    manifestations of celiac disease are complex, they may include characteristics\n                    of certain skin and nervous system disorders that develop due to additional\n                    transglutaminase autoimmunities. Such diseases are the severely pruritic,\n                    polymorphic autoimmune skin disease, dermatitis herpetiformis due to epidermal\n                    (type 3) transglutaminase autoimmunity, and a distinctive group of\n                    gluten-sensitive neuropathies with central and\/or peripheral neurological\n                    involvement caused by type 6 transglutaminase autoimmunity. While the celiac and\n                    skin autoimmune diseases gradually get into remission under a strict gluten-free\n                    diet, some neurological symptoms may persist. In the last decade, gluten-induced\n                    transglutaminase 6 positive but non-celiac (transglutaminase 2 negative)\n                    patients were reported. Today, various manifestations of gluten sensitivity are\n                    under extensive research. Early detection and interdisciplinary treatment of\n                    these disorders are important. Family screenings are of particular relevance in\n                    early recognition and dietary treatment of latent disease forms in order to\n                    prevent enteropathy-induced, malabsorption-related and other associated\n                    co-morbidities. Orv Hetil. 2021; 162(28): 1107\u20131118.<\/jats:p>","DOI":"10.1556\/650.2021.32046","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T10:06:49Z","timestamp":1630404409000},"page":"1107-1118","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["A sokarc\u00fa glut\u00e9n\u00e9rz\u00e9kenys\u00e9g: glut\u00e9ninduk\u00e1lt autoimmunit\u00e1s a b\u0151rgy\u00f3gy\u00e1sz szem\u00e9vel"],"prefix":"10.1556","volume":"162","author":[{"given":"Tam\u00e1s","family":"Malkovics","sequence":"first","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Doktori Iskola, Klinikai Orvostudom\u00e1nyok, Budapest"},{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamilla","family":"Koszor\u00fa","sequence":"additional","affiliation":[{"name":"1 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Doktori Iskola, Klinikai Orvostudom\u00e1nyok, Budapest"},{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarolta","family":"K\u00e1rp\u00e1ti","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Arat\u00f3","sequence":"additional","affiliation":[{"name":"3 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"G\u00f6r\u00f6g","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"S\u00e1rdy","sequence":"additional","affiliation":[{"name":"2 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, B\u0151r-, Nemik\u00f3rtani \u00e9s B\u0151ronkol\u00f3giai Klinika, Budapest, M\u00e1ria u. 41., 1085"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/ajg.2014.55","article-title":"Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study","volume":"109","author":"1 West","year":"2014","unstructured":"1 West J, Fleming KM, Tata LJ, et al. 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