{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:14:04Z","timestamp":1785464044329,"version":"3.56.0"},"reference-count":35,"publisher":"Akademiai Kiado Zrt.","issue":"14","license":[{"start":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T00:00:00Z","timestamp":1617494400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,4,4]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A szerz\u0151k ismertetik vizsg\u00e1lataik eredm\u00e9nyeit,\n                    melyeket a k\u00f6zelm\u00faltban az <jats:italic>in vitro<\/jats:italic> fertiliz\u00e1ci\u00f3s kezel\u00e9sben\n                    r\u00e9szes\u00fcl\u0151 betegeikben a t\u00fcsz\u0151folyad\u00e9k biomarkereinek anal\u00edzis\u00e9vel \u00e9rtek el. A\n                    vizsg\u00e1latok c\u00e9lja annak felt\u00e1r\u00e1sa volt, hogy az <jats:italic>in vitro<\/jats:italic>\n                    fertiliz\u00e1ci\u00f3s elj\u00e1r\u00e1s sor\u00e1n a petesejtek aspir\u00e1ci\u00f3jakor nyert\n                    t\u00fcsz\u0151folyad\u00e9k-biomarkerek lok\u00e1lis\/ovarialis vagy sziszt\u00e9m\u00e1s eredet\u0171ek, \u00e9s milyen\n                    \u00f6sszef\u00fcgg\u00e9st mutatnak az <jats:italic>in vitro<\/jats:italic> fertiliz\u00e1ci\u00f3 eredm\u00e9nyess\u00e9g\u00e9t\n                    jelz\u0151 param\u00e9terekkel. Meger\u0151s\u00edtett\u00fck, hogy az autokrin\/parakrin\n                    szerotoninrendszer m\u00e1r a fejl\u0151d\u00e9s legkor\u00e1bbi id\u0151szak\u00e1ban is m\u0171k\u00f6d\u0151k\u00e9pes, \u00e9s mind\n                    az anyai sz\u00e9rum, mind a t\u00fcsz\u0151folyad\u00e9k szerotoninszintje szignifik\u00e1ns pozit\u00edv\n                    \u00f6sszef\u00fcgg\u00e9st mutatott az \u00e9rett petesejtek sz\u00e1m\u00e1val \u00e9s a klinikai terhess\u00e9ggel (\u03b2\n                    = 0,447, p = 0,015, illetve \u03b2 = 0,443, p = 0,016). Az agyi eredet\u0171 neurotrofikus\n                    faktor (BDNF) eset\u00e9ben ilyen kapcsolat nem volt igazolhat\u00f3, de a t\u00fcsz\u0151folyad\u00e9k\n                    BDNF- \u00e9s szerotoninszintjei k\u00f6z\u00f6tti pozit\u00edv korrel\u00e1ci\u00f3 (r = 0,377, p = 0,040)\n                    azt mutatja, hogy a k\u00e9t neurohormon \u2019feed-forward\u2019 (el\u0151recsatol\u00f3 ) szab\u00e1lyoz\u00e1sa\n                    ovarialis szinten is m\u0171k\u00f6dik. A hypothalamicus kisspeptin eset\u00e9ben csup\u00e1n a\n                    posztstimul\u00e1ci\u00f3s anyai sz\u00e9rumhormonszint befoly\u00e1solta az \u00e9rett petesejtek sz\u00e1m\u00e1t\n                    (\u03b2 = 0,398, p = 0,029). A triptof\u00e1n\u2013kinurenin\u2013szerotonin rendszer elemz\u00e9se azt\n                    mutatta, hogy kedvez\u0151bb <jats:italic>in vitro<\/jats:italic> fertiliz\u00e1ci\u00f3s kimenetel\n                    v\u00e1rhat\u00f3, ha a szerotonin\u2013kinurenin egyens\u00faly a szerotonin jav\u00e1ra tol\u00f3dik el. Az\n                    oxidat\u00edvstressz-markerek k\u00f6z\u00fcl vizsg\u00e1lt\u00e1k a DNS-k\u00e1rosod\u00e1s biomarker\u00e9t, a\n                    8-hidroxi-2\u2019-deoxiguanozin \u00e9s a tot\u00e1lis antioxid\u00e1ns-kapacit\u00e1s sz\u00e9rum- \u00e9s\n                    t\u00fcsz\u0151folyad\u00e9kszintjeit, \u00e9s meg\u00e1llap\u00edtott\u00e1k, hogy mindk\u00e9t marker kedvez\u0151tlen\u00fcl\n                    befoly\u00e1solja az \u00e9letk\u00e9pes embri\u00f3k sz\u00e1m\u00e1t (r = 0,302, p = 0,027 \u00e9s r = 0,268, p =\n                    0,039). A protekt\u00edv hat\u00e1s\u00fa szirtuinok \u2013 nikotinamid-adenin-dinukleotid-f\u00fcgg\u0151\n                    hiszton-deacetil\u00e1z feh\u00e9rj\u00e9k \u2013 k\u00f6z\u00fcl a vizsg\u00e1lt szirtuin-1 \u00e9s szirtuin-6 a\n                    sz\u00e9rumszintekt\u0151l f\u00fcggetlen\u00fcl kimutathat\u00f3 a t\u00fcsz\u0151folyad\u00e9kban. Szignifik\u00e1ns\n                    pozit\u00edv korrel\u00e1ci\u00f3 van a t\u00fcsz\u0151folyad\u00e9k-szirtuin-6 \u00e9s az \u00e9rettpetesejt-sz\u00e1m (F =\n                    6,609, p = 0,016), valamint a sz\u00e9rum-szirtuin-1 (F = 10,008, p = 0,005) \u00e9s a\n                    sz\u00e9rum-szirtuin-6 (F = 5,268, p = 0,031) \u00e9s a klinikai terhess\u00e9g gyakoris\u00e1ga\n                    k\u00f6z\u00f6tt. Eredm\u00e9nyeink alapj\u00e1n meg\u00e1llap\u00edthat\u00f3, hogy a t\u00fcsz\u0151folyad\u00e9k biomarkereinek\n                    vizsg\u00e1lata jav\u00edthatja az <jats:italic>in vitro<\/jats:italic> fertiliz\u00e1ci\u00f3 kimenetel\u00e9nek\n                    meg\u00edt\u00e9l\u00e9s\u00e9t. Orv Hetil. 2021; 162(14): 523\u2013529.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> This article outlines the result of recent studies on\n                    several follicular fluid biomarkers in patients undergoing <jats:italic>in\n                        vitro<\/jats:italic> fertilization. The aim of these studies was to investigate\n                    whether 1) the follicular fluid biomarkers in question are produced locally by\n                    the ovaries or they originate from the circulating plasma, 2) and to establish\n                    their association with parameters of <jats:italic>in vitro<\/jats:italic> fertilization\n                    outcome. It was confirmed that the autocrine\/paracrine serotonin system is\n                    functional already at the earliest stage of development and both maternal serum\n                    and follicular fluid serotonin levels were positively related to the number of\n                    mature oocytes (\u03b2 = 0.447, p = 0.015 and \u03b2 = 0.443, p = 0.016, respectively) and\n                    clinical pregnancy (\u03b2 = 1.028, p = 0.047). Such associations for brain-derived\n                    neurotrophic factor (BDNF) could not be found, but BDNF and serotonin in the\n                    follicular fluid were closely related (r = 0.377, p&lt;0.040) suggesting that\n                    the feed-forward regulation of these neurohormones is activated at ovarian\n                    level. The hypothalamic kisspeptin in the post-stimulation maternal serum also\n                    increased the number of mature oocytes (\u03b2 = 0.398, p = 0.029). Analysis of the\n                    tryptophan\u2013kynurenine\u2013serotonin system showed a more favourable <jats:italic>in\n                        vitro<\/jats:italic> fertilization outcome when the serotonin\u2013kynurenine balance\n                    was shifted and serotonin predominated over kynurenine. The oxidative stress\n                    markers, 8-hydroxy-2\u2019-deoxyguanosine, an indicator of DNA damage and the total\n                    antioxidant capacity in follicular fluid and maternal serum had negative impact\n                    on the number of viable embryos (r = 0.302, p = 0.027 and r = 0.268, p = 0.039),\n                    respectively. The protective sirtuins \u2013 the nicotinamide adenine\n                    dinucleotide-dependent histone deacetylase proteins \u2013 could be detected in\n                    follicular fluid irrespective of their maternal serum levels. Significant\n                    positive relationship was demonstrated between follicular fluid sirtuin 6 and\n                    mature oocytes (F = 6.609, p = 0.016) as well as between serum sirtuin 1 (F =\n                    10.008, p = 0.005) and serum sirtuin 6 (F = 5.268, p = 0.031) and the rate of\n                    clinical pregnancy, respectively. On the basis of these results, it can be\n                    concluded that measuring several follicular fluid biomarkers may improve the\n                    prediction of the outcome of <jats:italic>in vitro<\/jats:italic> fertilization. Orv Hetil.\n                    2021; 162(14): 523\u2013529.<\/jats:p>","DOI":"10.1556\/650.2021.32067","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T04:16:05Z","timestamp":1617596165000},"page":"523-529","update-policy":"https:\/\/doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":4,"title":["A t\u00fcsz\u0151folyad\u00e9k biomarkereinek vizsg\u00e1lata in vitro fertiliz\u00e1ci\u00f3s kezel\u00e9sben r\u00e9szes\u00fclt betegekben"],"prefix":"10.1556","volume":"162","author":[{"given":"J\u00f3zsef","family":"B\u00f3dis","sequence":"first","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport, P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endre","family":"Sulyok","sequence":"additional","affiliation":[{"name":"2 P\u00e9csi Tudom\u00e1nyegyetem, Eg\u00e9szs\u00e9gtudom\u00e1nyi Kar, Eg\u00e9szs\u00e9gtudom\u00e1nyi Doktori Iskola, P\u00e9cs, V\u00f6r\u00f6smarty u. 4., 7621"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"V\u00e1rnagy","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport, P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Kopp\u00e1n","sequence":"additional","affiliation":[{"name":"1 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Sz\u00fcl\u00e9szeti \u00e9s N\u0151gy\u00f3gy\u00e1szati Klinika, Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport, P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Kov\u00e1cs L.","sequence":"additional","affiliation":[{"name":"3 P\u00e9csi Tudom\u00e1nyegyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, Szent\u00e1gothai J\u00e1nos Kutat\u00f3k\u00f6zpont, Hum\u00e1n Reprodukci\u00f3s Kutat\u00f3csoport, P\u00e9cs"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1 F\u00fcl\u00f6p V, Vermes G, Demeter J. 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