{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T13:15:58Z","timestamp":1698844558652},"reference-count":49,"publisher":"Akademiai Kiado Zrt.","issue":"19","license":[{"start":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:00:00Z","timestamp":1620518400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["OH"],"published-print":{"date-parts":[[2021,5,9]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> A hum\u00e1n mikrobiom az emberi szervezetben \u00e9s az emberi\n                    testfelsz\u00ednen \u00e9l\u0151 mikrobak\u00f6z\u00f6ss\u00e9gek \u00f6sszess\u00e9ge, amelyek t\u00f6bbs\u00e9ge a gyomor-b\u00e9l\n                    rendszerben \u00e9l. Ezek a mikrobak\u00f6z\u00f6ss\u00e9gek sz\u00e1mos \u00e9s sokf\u00e9le bakt\u00e9riumot\n                    tartalmaznak, gomb\u00e1kat, v\u00edrusokat, arche\u00e1kat \u00e9s protozoonokat. Ez a mikrobi\u00e1lis\n                    k\u00f6z\u00f6ss\u00e9g, vagy mikrobiota, a gazdaszervezetben nagyr\u00e9szt egym\u00e1ssal k\u00f6lcs\u00f6n\u00f6ss\u00e9gi\n                    viszonyban teny\u00e9szik, \u00e9s gondoskodik a b\u00e9lben a t\u00e1panyagok anyagcser\u00e9j\u00e9r\u0151l,\n                    kalibr\u00e1lja az anyagcsere-m\u0171k\u00f6d\u00e9st, tan\u00edtja az immunrendszert, fenntartja a\n                    k\u00f6z\u00f6ss\u00e9g integrit\u00e1s\u00e1t, \u00e9s v\u00e9d a k\u00f3rokoz\u00f3k ellen. A majdan megsz\u00fcletend\u0151 magzat a\n                    megfelel\u0151 t\u00e1panyagell\u00e1t\u00e1s\u00e1t az anyai v\u00e9r\u00e1ramb\u00f3l kapja, \u00e9s \u00edgy az anyai\n                    szervezetben a mikrobiota induk\u00e1lta bakt\u00e9riumkomponensek vagy metabolitok\n                    hat\u00e9konyan \u00e1tvihet\u0151k a magzatba. Az anyai mikrobi\u00e1lis k\u00f6z\u00f6ss\u00e9gek \u2013 ide\u00e9rtve a\n                    praenatalis b\u00e9lrendszeri, h\u00fcvelyi, sz\u00e1j- \u00e9s b\u0151rmikrobiomot \u2013 a terhess\u00e9g alatt\n                    val\u00f3j\u00e1ban kifejezett v\u00e1ltoz\u00e1sokon mennek kereszt\u00fcl, amelyek befoly\u00e1solhatj\u00e1k az\n                    eg\u00e9szs\u00e9g meg\u0151rz\u00e9s\u00e9t, \u00e9s hozz\u00e1j\u00e1rulhatnak a k\u00f6zismert betegs\u00e9gek kialakul\u00e1s\u00e1hoz.\n                    A magzat nem steril, \u00e9s immunol\u00f3giai szempontb\u00f3l sem naiv, hanem az anya r\u00e9v\u00e9n\n                    k\u00f6rnyezeti ingerek hat\u00e1sait\u00f3l befoly\u00e1solva k\u00f6lcs\u00f6nhat\u00e1sba l\u00e9p az anyai\n                    immunrendszerrel. Sz\u00e1mos anyai t\u00e9nyez\u0151 \u2013 bele\u00e9rtve a hormonokat, a citokineket\n                    \u00e9s a mikrobiomot \u2013 m\u00f3dos\u00edthatja az intrauterin k\u00f6rnyezetet, ez\u00e1ltal befoly\u00e1solva\n                    a magzati immunrendszer fejl\u0151d\u00e9s\u00e9t. A fokozott stresszben \u00e9l\u0151 any\u00e1k csecsem\u0151in\u00e9l\n                    nagyobb az allergia \u00e9s a gyomor-b\u00e9l rendszeri rendelleness\u00e9gek ar\u00e1nya. A\n                    v\u00e1rand\u00f3s \u00e9trendje is befoly\u00e1solja a magzati mikrobiomot a m\u00e9h k\u00f6zvet\u00edt\u00e9s\u00e9vel. A\n                    b\u00e9lfl\u00f3r\u00e1nk, vagyis a mikrobiom, a bel\u00fcnkben \u00e9l\u0151 mikrob\u00e1k \u00f6sszess\u00e9ge \u00e9s\n                    szimbi\u00f3zisa, amelynek k\u00e9nyes egyens\u00falya m\u00e1r csecsem\u0151korban kialakul, \u00e9s d\u00f6nt\u0151en\n                    meghat\u00e1rozza az intestinalis barrier \u00e9s a b\u00e9lasszoci\u00e1lt immunrendszer m\u0171k\u00f6d\u00e9s\u00e9t.\n                    A probiotikumok szaporod\u00e1s\u00e1hoz sz\u00fcks\u00e9ges prebiotikummal is befoly\u00e1solhat\u00f3 a\n                    b\u00e9lfl\u00f3ra. A pre- \u00e9s a probiotikum kombin\u00e1ci\u00f3ja a szimbiotikum. Az anyatej a\n                    patog\u00e9nekkel szemben protekt\u00edv hat\u00e1s\u00fa, r\u00e9szben az\u00e1ltal, hogy emeli a\n                        <jats:italic>Bifidobacterium-<\/jats:italic>sz\u00e1mot az \u00fajsz\u00fcl\u00f6tt b\u00e9lfl\u00f3r\u00e1j\u00e1ban. A\n                    dysbiosis a kommenz\u00e1lis, eg\u00e9szs\u00e9ges b\u00e9lfl\u00f3ra megv\u00e1ltoz\u00e1sa. Ennek szerep\u00e9t\n                    felt\u00e9telezik funkcion\u00e1lis gastrointestinalis k\u00f3rk\u00e9pekben, egyre t\u00f6bb\n                    pszichi\u00e1triai \u00e9s neurol\u00f3giai k\u00f3rk\u00e9pben is, mint az autizmus-spektrumzavar. Orv\n                    Hetil. 2021; 162(19): 731\u2013740.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> The human microbiome is the totality of microbe communities\n                    living in the human body and on the human body surface, most of which live in\n                    the gastrointestinal tract. These microbe communities contain many and varied\n                    bacteria, fungi, viruses, archaea and protozoa. This microbial community or\n                    microbiota in the host is largely reciprocal and takes care of nutrient\n                    metabolism in the gut, calibrates metabolism, teaches the immune system,\n                    maintains community integrity, and protects against pathogens. The fetus to be\n                    born is adequately supplied with nutrients from the maternal bloodstream, and\n                    thus microbial-induced bacterial components or metabolites can be efficiently\n                    transferred to the fetus in the maternal body. Maternal microbial communities,\n                    including prenatal intestinal, vaginal, oral, and dermal microbiomes, actually\n                    undergo pronounced changes during pregnancy that can affect health maintenance\n                    and contribute to the development of well-known diseases. The fetus is not\n                    sterile or immunologically na\u00efve, but interacts with the maternal immune system\n                    through the effects of environmental stimuli through the mother. Many maternal\n                    factors, including hormones, cytokines, and the microbiome, can modify the\n                    intrauterine environment, thereby affecting the development of the fetal immune\n                    system. Infants of mothers under increased stress have higher rates of allergies\n                    and gastrointestinal disorders. The diet of the gravida also affects the fetal\n                    microbiome through the uterus. Our intestinal flora, or microbiome, is the\n                    totality and symbiosis of the microbes living in them, the delicate balance of\n                    which is established in infancy and decisively determines the functioning of the\n                    intestinal barrier and the intestinal associated immune system. The prebiotic\n                    required for the proliferation of probiotics can also affect the intestinal\n                    flora. The combination of pre- and probiotic is symbiotic. Breast milk has a\n                    protective effect against pathogens, in part by raising the number of\n                        <jats:italic>Bifidobacteria<\/jats:italic> in the intestinal flora of the newborn.\n                    Dysbiosis is a change in the commensal, healthy gut flora. Its role is\n                    hypothesized in functional gastrointestinal disorders, as well as in more and\n                    more psychiatric and neurological disorders such as the autism spectrum\n                    disorder. Orv Hetil. 2021; 162(19): 731\u2013740.<\/jats:p>","DOI":"10.1556\/650.2021.32082","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T10:03:55Z","timestamp":1630404235000},"page":"731-740","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":2,"title":["A praenatalis \u00e9s postnatalis mikrobiom jelent\u0151s\u00e9ge \u00e9s hat\u00e1sai a korai egyedfejl\u0151d\u00e9s id\u0151szak\u00e1ban \u00e9s az intervenci\u00f3s kezel\u00e9s lehet\u0151s\u00e9gei"],"prefix":"10.1556","volume":"162","author":[{"given":"Vilmos","family":"F\u00fcl\u00f6p","sequence":"first","affiliation":[{"name":"1 Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly, Semmelweis Egyetem Gyakorl\u00f3 K\u00f3rh\u00e1z, Budapest, Podmaniczky u. 111., 1062"},{"name":"2 Miskolci Egyetem, Eg\u00e9szs\u00e9g\u00fcgyi Kar, Miskolc"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Demeter","sequence":"additional","affiliation":[{"name":"1 Magyar Honv\u00e9ds\u00e9g Eg\u00e9szs\u00e9g\u00fcgyi K\u00f6zpont, Sz\u00fcl\u00e9szet-n\u0151gy\u00f3gy\u00e1szati Oszt\u00e1ly, Semmelweis Egyetem Gyakorl\u00f3 K\u00f3rh\u00e1z, Budapest, Podmaniczky u. 111., 1062"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ron","family":"Cseh","sequence":"additional","affiliation":[{"name":"3 Semmelweis Egyetem, \u00c1ltal\u00e1nos Orvostudom\u00e1nyi Kar, I. Gyermekgy\u00f3gy\u00e1szati Klinika, Budapest"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"931574","DOI":"10.1155\/2015\/931574","article-title":"Intestinal microbiota as modulators of the immune system and neuroimmune system: impact on the host health and homeostasis","volume":"2015","author":"1 Maranduba","year":"2015","unstructured":"1 Maranduba CM, De Castro SB, De Souza GT, et al. Intestinal microbiota as modulators of the immune system and neuroimmune system: impact on the host health and homeostasis. J Immunol Res. 2015; 2015: 931574.","journal-title":"J Immunol Res"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.immuni.2014.05.014","article-title":"Diet, metabolites, and \"western-lifestyle\" inflammatory diseases","volume":"40","author":"2 Thorburn","year":"2014","unstructured":"2 Thorburn AN, Macia L, Mackay CR. Diet, metabolites, and \"western-lifestyle\" inflammatory diseases. Immunity 2014; 40: 833-842.","journal-title":"Immunity"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.smim.2006.10.002","article-title":"Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota","volume":"19","author":"3 Smith","year":"2007","unstructured":"3 Smith K, McCoy KD, Macpherson AJ. Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota. Semin Immunol. 2007; 19: 59-69.","journal-title":"Semin Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.3389\/fmicb.2016.01031","article-title":"Microbial changes during pregnancy, birth, and infancy","volume":"7","author":"4 Nuriel-Ohayon","year":"2016","unstructured":"4 Nuriel-Ohayon M, Neuman H, Koren O. Microbial changes during pregnancy, birth, and infancy. Front Microbiol. 2016; 7: 1031.","journal-title":"Front Microbiol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nri.2017.64","article-title":"The unique immunological and microbial aspects of pregnancy","volume":"17","author":"5 Mor","year":"2017","unstructured":"5 Mor G, Aldo P, Alvero AB. The unique immunological and microbial aspects of pregnancy. Nat Rev Immunol. 2017; 17: 469-482.","journal-title":"Nat Rev Immunol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1080\/1040841X.2016.1211088","article-title":"Planting the seed: origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota","volume":"43","author":"6 Stinson","year":"2017","unstructured":"6 Stinson LF, Payne MS, Keelan JA. Planting the seed: origins, composition, and postnatal health significance of the fetal gastrointestinal microbiota. Crit Rev Microbiol. 2017; 43: 352-369.","journal-title":"Crit Rev Microbiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/pr.2014.163","article-title":"Maternal influences on fetal microbial colonization and immune development","volume":"77","author":"Romano-Keeler J","year":"2015","unstructured":"7 Romano-Keeler J, Weitkamp JH. Maternal influences on fetal microbial colonization and immune development. Pediatr Res. 2015; 77: 189-195.","journal-title":"Pediatr Res"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8 Moles L, G\u00f2mez M, Heilig H, et al. Bacterial diversity in meconium of preterm neonates and evolution of their fecal microbiota during the first month of life. PLoS ONE 2013; 8: e66986.","DOI":"10.1371\/journal.pone.0066986"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9 B\u00e4ckhed F, Roswall J, Peng Y, et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe 2015; 17: 690-703. [Erratum: Cell Host Microbe 2015; 17: 852.]","DOI":"10.1016\/j.chom.2015.04.004"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00005-015-0329-y","article-title":"Mucosal immune development in early life: setting the stage","volume":"63","author":"10 Brugman","year":"2015","unstructured":"10 Brugman S, Perdijk O, van Neerven R, et al. Mucosal immune development in early life: setting the stage. Arch Immunol Ther Exp (Warsz). 2015; 63: 251-268.","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11 Smolen KK, Ruck CE, Fortuno ES 3rd, et al. Pattern recognition receptor-mediated cytokine response in infants across 4 continents. J Allergy Clin Immunol. 2014; 133: 818-826.e4.","DOI":"10.1016\/j.jaci.2013.09.038"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/ht7040038","article-title":"The prenatal microbiome: a new player for human health","volume":"7","author":"12 D'Argenio","year":"2018","unstructured":"12 D'Argenio V. The prenatal microbiome: a new player for human health. High Throughput 2018; 7: 38.","journal-title":"High Throughput"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/cea.12063","article-title":"Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants","volume":"43","author":"13 Gosalbes","year":"2013","unstructured":"13 Gosalbes MJ, Llop S, Vall\u00e8s Y, et al. Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants. Clin Exp Allergy 2013; 43: 198-211.","journal-title":"Clin Exp Allergy"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jpeds.2009.06.063","article-title":"Intestinal microbial ecology in premature infants assessed with non-culture-based techniques","volume":"156","author":"14 Mshvildadze","year":"2010","unstructured":"14 Mshvildadze M, Neu J, Shuster J, et al. Intestinal microbial ecology in premature infants assessed with non-culture-based techniques. J Pediatr. 2010; 156: 20-25.","journal-title":"J Pediatr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nm.4272","article-title":"Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery","volume":"23","author":"15 Chu","year":"2017","unstructured":"15 Chu DM, Ma J, Prince AL, et al. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nat Med. 2017; 23: 314-326.","journal-title":"Nat Med"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s00284-005-0020-3","article-title":"Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section","volume":"51","author":"16 Jim\u00e9nez","year":"2005","unstructured":"16 Jim\u00e9nez E, Fern\u00e1ndez L, Mar\u00edn ML, et al. Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section. Curr Microbiol. 2005; 51: 270-274.","journal-title":"Curr Microbiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"11971","DOI":"10.1073\/pnas.1002601107","article-title":"Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns","volume":"107","author":"17 Dominguez-Bello","year":"2010","unstructured":"17 Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA 2010; 107: 11971-11975.","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18 Del Chierico F, Vernocchi P, Petrucca A, et al. Phylogenetic and metabolic tracking of gut microbiota during perinatal development. PLoS ONE 2015; 10: e0137347.","DOI":"10.1371\/journal.pone.0137347"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19 Aagaard K, Ma J, Antony KM, et al. The placenta harbors a unique microbiome. Sci Transl Med. 2014; 6: 237ra65.","DOI":"10.1126\/scitranslmed.3008599"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/1469-0691.12411","article-title":"Antibiotic use during pregnancy alters the commensal vaginal microbiota","volume":"20","author":"20 Stokholm","year":"2014","unstructured":"20 Stokholm J, Schj\u00f8rring S, Eskildsen CE, et al. Antibiotic use during pregnancy alters the commensal vaginal microbiota. Clin Microbiol Infect. 2014; 20: 629-635.","journal-title":"Clin Microbiol Infect"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/gutjnl-2019-319101","article-title":"Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation","volume":"69","author":"21 Chen","year":"2020","unstructured":"21 Chen X, Li P, Liu M, et al. Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation. Gut 2020; 69: 513-522.","journal-title":"Gut"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.psyneuen.2015.01.006","article-title":"Maternal prenatal stress is associated with the infant intestinal microbiota","volume":"53","author":"22 Zijlmans","year":"2015","unstructured":"22 Zijlmans MA, Korpela K, Riksen-Walraven JM, et al. Maternal prenatal stress is associated with the infant intestinal microbiota. Psychoneuroendocrinology 2015; 53: 233-245.","journal-title":"Psychoneuroendocrinology"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"892","DOI":"10.2174\/1570159X14666160404124127","article-title":"Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (IBD): role of brain-gut axis","volume":"14","author":"23 Brzozowski","year":"2016","unstructured":"23 Brzozowski B, Mazur-Bialy A, Pajdo R. Mechanisms by which stress affects the experimental and clinical inflammatory bowel disease (IBD): role of brain-gut axis. Curr Neuropharmacol. 2016; 14: 892-900.","journal-title":"Curr Neuropharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/mi.2008.61","article-title":"Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages","volume":"1","author":"24 Kelsall","year":"2008","unstructured":"24 Kelsall B. Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages. Mucosal Immunol. 2008; 1: 460-469.","journal-title":"Mucosal Immunol"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25 Perez PF, Dor\u00e9 J, Leclerc M, et al. Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics 2007; 119: e724-7e32.","DOI":"10.1542\/peds.2006-1649"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"2860","DOI":"10.1038\/s41598-017-03066-4","article-title":"Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women","volume":"7","author":"26 Gomez-Arango","year":"2017","unstructured":"26 Gomez-Arango LF, Barrett HL, McIntyre HD, et al. Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women. Sci Rep. 2017; 7: 2860.","journal-title":"Sci Rep"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27 Walker RW, Clemente JC, Peter I, et al. The prenatal gut microbiome: are we colonized with bacteria in utero? Pediatr Obes. 2017; 12(Suppl 1): 3-17.","DOI":"10.1111\/ijpo.12217"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28 Kacerovsky M, Pliskova L, Bolehovska R, et al. The impact of the microbial load of genital mycoplasmas and gestational age on the intensity of intraamniotic inflammation. Am J Obstet Gynecol. 2012; 206: 342.e1-342.e8.","DOI":"10.1016\/j.ajog.2012.01.004"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1017\/S2040174415001269","article-title":"Fetal programming of overweight through the microbiome: boys are disproportionately affected","volume":"7","author":"29 Kozyrskyj","year":"2016","unstructured":"29 Kozyrskyj AL, Kalu R, Koleva PT, et al. Fetal programming of overweight through the microbiome: boys are disproportionately affected. J Dev Orig Health Dis. 2016; 7: 25-34.","journal-title":"J Dev Orig Health Dis"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s00125-016-3880-0","article-title":"Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle","volume":"59","author":"30 Soderborg","year":"2016","unstructured":"30 Soderborg TK, Borengasser SJ, Barbour LA, et al. Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle. Diabetologia 2016; 59: 895-906.","journal-title":"Diabetologia"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1126\/science.aad2571","article-title":"The maternal microbiota drives early postnatal innate immune development","volume":"351","author":"31 Gomez de Ag\u00fcero","year":"2016","unstructured":"31 Gomez de Ag\u00fcero M, Ganal-Vonarburg SC, Fuhrer T, et al. The maternal microbiota drives early postnatal innate immune development. Science 2016; 351: 1296-1302.","journal-title":"Science"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1080\/19490976.2017.1299847","article-title":"Maternal microbiota and antibodies as advocates of neonatal health","volume":"8","author":"32 Ganal-Vonarburg","year":"2017","unstructured":"32 Ganal-Vonarburg SC, Fuhrer T, Gomez de Ag\u00fcero M. Maternal microbiota and antibodies as advocates of neonatal health. Gut Microbes 2017; 8: 479-485.","journal-title":"Gut Microbes"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1038\/s41467-019-10703-1","article-title":"Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia","volume":"10","author":"33 Hu","year":"2019","unstructured":"33 Hu M, Eviston D, Hsu P, et al. Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia. Nat Commun. 2019; 10: 3031.","journal-title":"Nat Commun"},{"key":"ref33","unstructured":"34 F\u00fcl\u00f6p V. Immunological characteristics of the fetus and the newborn. In F\u00fcl\u00f6p V. (ed.) Current issues in immunology in human reproduction. [A magzat \u00e9s az \u00fajsz\u00fcl\u00f6tt immunol\u00f3giai jellemz\u0151i. In: F\u00fcl\u00f6p V. (szerk.) Az immunol\u00f3gia id\u0151szer\u0171 k\u00e9rd\u00e9sei a hum\u00e1nreprodukci\u00f3ban.] Semmelweis Kiad\u00f3, Budapest, 2008; pp. 93-100. [Hungarian]"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1007\/s10620-020-06092-x","article-title":"Microbiome composition in pediatric populations from birth to adolescence: impact of diet and prebiotic and probiotic interventions","volume":"65","author":"35 Davis","year":"2020","unstructured":"35 Davis EC, Dinsmoor AM, Wang M, et al. Microbiome composition in pediatric populations from birth to adolescence: impact of diet and prebiotic and probiotic interventions. Dig Dis Sci. 2020; 65: 706-722.","journal-title":"Dig Dis Sci"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"36 Gibson","year":"2017","unstructured":"36 Gibson GR, Hutkins R, Sanders ME. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017; 14: 491-502.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tifs.2018.03.009","article-title":"Postbiotics: an evolving term within the functional foods field","volume":"75","author":"Aguilar-Toal\u00e1","year":"2018","unstructured":"37 Aguilar-Toal\u00e1, JE, Garc\u00eda-Varela R, Garcia HS. Postbiotics: an evolving term within the functional foods field. Trends Food Sci Tech. 2018; 75: 105-114.","journal-title":"Trends Food Sci Tech"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1017\/S0954422410000090","article-title":"The probiotic paradox: live and dead cells are biological response modifiers","volume":"23","author":"38 Adams","year":"2010","unstructured":"38 Adams CA. The probiotic paradox: live and dead cells are biological response modifiers. Nutr Res Rev. 2010; 23: 37-46.","journal-title":"Nutr Res Rev"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/nature11400","article-title":"Antibiotics in early life alter the murine colonic microbiome and adiposity","volume":"488","author":"39 Cho","year":"2012","unstructured":"39 Cho I, Yamanishi S, Cox L, et al. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 2012; 488: 621-626.","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nature25979","article-title":"Extensive impact of non-antibiotic drugs on human gut bacteria","volume":"555","author":"40 Maier","year":"2018","unstructured":"40 Maier L, Pruteanu M, Kuhn M, et al. Extensive impact of non-antibiotic drugs on human gut bacteria. Nature 2018; 555: 623-628.","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"41 Kataria J, Li N, Wynn JL, et al. Probiotic microbes: do they need to be alive to be beneficial? Nutr Rev. 2009; 67: 546-550.","DOI":"10.1111\/j.1753-4887.2009.00226.x"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1097\/MPG.0b013e3181adaee0","article-title":"Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition","volume":"50","author":"42 Agostoni","year":"2010","unstructured":"42 Agostoni C, Buonocore G, Carnielli VP. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010; 50: 85-91.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1017\/S000711450999198X","article-title":"Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC\/Nga mice","volume":"103","author":"43 Fujiwara","year":"2010","unstructured":"43 Fujiwara R, Takemura N, Watanabe J, et al. Maternal consumption of fructo-oligosaccharide diminishes the severity of skin inflammation in offspring of NC\/Nga mice. Br J Nutr. 2010; 103: 530-538.","journal-title":"Br J Nutr"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"133","DOI":"10.3390\/nu12010133","article-title":"The evolving microbiome from pregnancy to early infancy: a comprehensive review","volume":"12","author":"44 Mesa","year":"2020","unstructured":"44 Mesa MD, Loureiro B, Iglesia I, et al. The evolving microbiome from pregnancy to early infancy: a comprehensive review. Nutrients 2020; 12: 133.","journal-title":"Nutrients"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.3390\/ijms20102432","article-title":"Dysbiosis disrupts gut immune homeostasis and promotes gastric diseases","volume":"20","author":"45 Toor","year":"2019","unstructured":"45 Toor D, Wsson MK, Kumar P, et al. Dysbiosis disrupts gut immune homeostasis and promotes gastric diseases. Int J Mol Sci. 2019; 20: 2432.","journal-title":"Int J Mol Sci"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/gm135","article-title":"Developmental origins of health and disease: reducing the burden of chronic disease in the next generation","volume":"2","author":"46 Gluckman","year":"2010","unstructured":"46 Gluckman PD, Hanson MA, Mitchell MD. Developmental origins of health and disease: reducing the burden of chronic disease in the next generation. Genome Med. 2010; 2: 14.","journal-title":"Genome Med"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/S0140-6736(18)31930-5","article-title":"Short-term and long-term effects of caesarean section on the health of women and children","volume":"392","author":"47 Sandall","year":"2018","unstructured":"47 Sandall J, Tribe RM, Avery L, et al. Short-term and long-term effects of caesarean section on the health of women and children. Lancet 2018; 392: 1349-1357.","journal-title":"Lancet"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mib.2018.06.003","article-title":"Early life colonization of the human gut: microbes matter everywhere","volume":"44","author":"Korpela K","year":"2018","unstructured":"48 Korpela K, de Vos WM. Early life colonization of the human gut: microbes matter everywhere. Curr Opin Microbiol. 2018; 44: 70-78.","journal-title":"Curr Opin Microbiol"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"49 Korpela K, Helve O, Kolho KL, et al. Maternal fecal microbiota transplantation in cesarean-born infants rapidly restores normal gut microbial development: a proof-of-concept study. Cell 2020; 183: 324-334.e5.","DOI":"10.1016\/j.cell.2020.08.047"}],"container-title":["Orvosi Hetilap"],"original-title":[],"link":[{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/162\/19\/article-p731.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/akjournals.com\/downloadpdf\/journals\/650\/162\/19\/article-p731.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:43:15Z","timestamp":1698756195000},"score":1,"resource":{"primary":{"URL":"https:\/\/akjournals.com\/view\/journals\/650\/162\/19\/article-p731.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,9]]},"references-count":49,"journal-issue":{"issue":"19"},"URL":"https:\/\/doi.org\/10.1556\/650.2021.32082","relation":{},"ISSN":["0030-6002","1788-6120"],"issn-type":[{"value":"0030-6002","type":"print"},{"value":"1788-6120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,9]]}}}