{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T05:55:32Z","timestamp":1747806932938},"reference-count":12,"publisher":"Akademiai Kiado Zrt.","issue":"22","content-domain":{"domain":["akjournals.com"],"crossmark-restriction":true},"short-container-title":["Orv Hetil."],"published-print":{"date-parts":[[2021,5,30]]},"abstract":"<jats:p><jats:bold>\u00d6sszefoglal\u00f3.<\/jats:bold> Az elt\u0171n\u0151epe\u00fat-szindr\u00f3ma ritka, rossz progn\u00f3zis\u00fa\n                    k\u00f3rk\u00e9p. Az epeutak progressz\u00edv destrukci\u00f3j\u00e1val, az intrahepaticus epeutak\n                    elt\u0171n\u00e9s\u00e9vel j\u00e1r, epepang\u00e1shoz, biliaris cirrhosishoz, v\u00e9g\u00fcl m\u00e1jel\u00e9gtelens\u00e9ghez\n                    vezet. A h\u00e1tt\u00e9rben \u00e1ll\u00f3 kiv\u00e1lt\u00f3 okok k\u00f6z\u00f6tt infekci\u00f3k, ischaemia,\n                    gy\u00f3gyszermell\u00e9khat\u00e1sok, illetve daganatos megbeteged\u00e9sek szerepelhetnek. A\n                    malignit\u00e1sok k\u00f6z\u00fcl a leggyakrabban a Hodgkin-lymphom\u00e1hoz t\u00e1rsult form\u00e1j\u00e1val\n                    tal\u00e1lkozhatunk. Cikk\u00fcnkben egy fiatal, Hodgkin-lymphom\u00e1s beteg\u00fcnk eset\u00e9t\n                    szeretn\u00e9nk bemutatni, akin\u00e9l az icterus h\u00e1tter\u00e9ben elt\u0171n\u0151epe\u00fat-szindr\u00f3ma\n                    igazol\u00f3dott, melyet egy\u00e9b okok kiz\u00e1r\u00e1s\u00e1t k\u00f6vet\u0151en sz\u00f6vettani mintav\u00e9tellel\n                    igazoltunk. A k\u00e9t ciklus ABVD-protokoll szerinti kezel\u00e9st k\u00f6vet\u0151 PET\/CT az\n                    alapbetegs\u00e9g tekintet\u00e9ben komplett metabolikus remisszi\u00f3t igazolt. A klinikai\n                    javul\u00e1shoz azonban hossz\u00fa h\u00f3napokra volt sz\u00fcks\u00e9g. V\u00e9g\u00fcl az epe\u00fatelt\u0171n\u00e9s\n                    eset\u00fcnkben reverzibilis folyamatnak bizonyult, az alapbetegs\u00e9g tekintet\u00e9ben a\n                    komplett metabolikus remisszi\u00f3 el\u00e9r\u00e9s\u00e9vel az epe\u00fat-k\u00e1rosod\u00e1s meg\u00e1ll\u00edthat\u00f3 volt.\n                    Orv Hetil. 2021; 162(22): 884\u2013888.<\/jats:p>\n                <jats:p><jats:bold>Summary.<\/jats:bold> destruction and loss of the intrahepatic bile ducts leading\n                    to cholestatis, biliar chirrosis and finally liver failure. It has been\n                    described in different pathologic conditions including infections, ischemia,\n                    adverse drug reactions and malignancies. The Hodgkin\u2019s lymphoma-associated type\n                    occurs most frequently among the forms of the disease of malignant origin. In\n                    this report, we introduce the case of a 32-year-old male patient with Hodgkin\u2019s\n                    lymphoma, diagnosed with vanishing bile duct syndrome upon liver biopsy as a\n                    root cause behind his icterus. The PET\/CT has proven complete metabolic\n                    remission after 2 cycles of ABVD chemoterapy. Clinical improvement, however,\n                    occurred only after several months. Finally the loss of bile ducts proved to be\n                    a reversible process, the complete metabolic remission of Hodgkin\u2019s lymphoma\n                    resulted in the regeneration of the bile ducts. Orv Hetil. 2021; 162(22):\n                    884\u2013888.<\/jats:p>","DOI":"10.1556\/650.2021.32093","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T10:03:58Z","timestamp":1630404238000},"page":"884-888","update-policy":"http:\/\/dx.doi.org\/10.1556\/policypage.crossmark.crossref.1","source":"Crossref","is-referenced-by-count":1,"title":["Hodgkin-lymphom\u00e1hoz t\u00e1rsult elt\u0171n\u0151epe\u00fat-szindr\u00f3ma"],"prefix":"10.1556","volume":"162","author":[{"given":"Szandra","family":"Boldizs\u00e1r","sequence":"first","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Kemoter\u00e1pia A Oszt\u00e1ly, Budapest, R\u00e1th Gy\u00f6rgy utca 7\u20139., 1122"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Rottek","sequence":"additional","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Kemoter\u00e1pia A Oszt\u00e1ly, Budapest, R\u00e1th Gy\u00f6rgy utca 7\u20139., 1122"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Schneider","sequence":"additional","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Kemoter\u00e1pia A Oszt\u00e1ly, Budapest, R\u00e1th Gy\u00f6rgy utca 7\u20139., 1122"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Varga","sequence":"additional","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Kemoter\u00e1pia A Oszt\u00e1ly, Budapest, R\u00e1th Gy\u00f6rgy utca 7\u20139., 1122"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Szaleczky","sequence":"additional","affiliation":[{"name":"1 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Kemoter\u00e1pia A Oszt\u00e1ly, Budapest, R\u00e1th Gy\u00f6rgy utca 7\u20139., 1122"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"425","reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3748\/wjg.v23.i2.366","article-title":"Vanishing bile duct syndrome in Hodgkin's lymphoma: a case report and literature review","volume":"23","author":"1 Bakhit","year":"2017","unstructured":"1 Bakhit M, McCarty TR, Park S, et al. Vanishing bile duct syndrome in Hodgkin's lymphoma: a case report and literature review. World J Gastroenterol. 2017; 23: 366-372.","journal-title":"World J Gastroenterol"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/hep.1840170114","article-title":"Vanishing bile duct syndrome: a possible mechanism for intrahepatic cholestasis in Hodgkin's lymphoma","volume":"17","author":"2 Hubscher","year":"1993","unstructured":"2 Hubscher SG, Lumley MA, Elias E. Vanishing bile duct syndrome: a possible mechanism for intrahepatic cholestasis in Hodgkin's lymphoma. Hepatology 1993; 17: 70-77.","journal-title":"Hepatology"},{"key":"ref2","unstructured":"3 De Medeiros BC, Lacerda MA, Telles JE, et al. Cholestasis secondary to Hodgkin's disease: report of 2 cases of vanishing bile duct syndrome. Haematologica 1998; 83: 1038-1040."},{"key":"ref3","unstructured":"4 Amer S, Muqeetadnan M, Rahman A, et al. Vanishing bile duct syndrome: a rare cause of jaundice in Hodgkin's lymphoma. Turk J Gastroenterol. 2013; 24: 444-446."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5 Anugwom C, Goetz G, Hassan M. Vanishing bile duct syndrome preceding the diagnosis of Hodgkin lymphoma. ACG Case Rep J. 2020; 7: e00336.","DOI":"10.14309\/crj.0000000000000336"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6 Ludwig J, Wiesner RH, LaRusso FN. Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis. J Hepatol. 1988; 7: 193-199.","DOI":"10.1016\/S0168-8278(88)80482-3"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1080\/02841860701644078","article-title":"Hodgkin lymphoma-related vanishing bile duct syndrome and idiopathic cholestasis: statistical analysis of all published cases and literature review","volume":"47","author":"7 Ballonoff","year":"2008","unstructured":"7 Ballonoff A, Kavanagh B, Nash R, et al. Hodgkin lymphoma-related vanishing bile duct syndrome and idiopathic cholestasis: statistical analysis of all published cases and literature review. Acta Oncol. 2008; 47: 962-970.","journal-title":"Acta Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1023\/A:1010679502324","article-title":"Idiopathic adulthood ductopenia: long-term follow-up after liver transplantation","volume":"46","author":"8 Rios","year":"2001","unstructured":"8 Rios R, Herrero JI, Quiroga J, et al. 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Acta Oncol. 2014; 53: 1271-1275.","DOI":"10.3109\/0284186X.2014.897001"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/jgh.14503","article-title":"Hepatobiliary and pancreatic: sertraline-induced vanishing bile duct syndrome treated with plasmapheresis","volume":"34","author":"11 Tejedor-Tejada","year":"2019","unstructured":"11 Tejedor-Tejada J, Garc\u00eda-Pajares F, Madrigal Rubiales MB. Hepatobiliary and pancreatic: sertraline-induced vanishing bile duct syndrome treated with plasmapheresis. J Gastroenterol Hepatol. 2019; 34: 488.","journal-title":"J Gastroenterol Hepatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1097\/MCG.0000000000000548","article-title":"Vanishing bile duct syndrome in Hodgkin's lymphoma: a single center experience and clinical pearls","volume":"50","author":"12 Bakhit","year":"2016","unstructured":"12 Bakhit M, McCarty TR, Park S, et al. 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